Dijin Xu, Yuqi Li, Lizhen Wu, Ying Li, Dongyu Zhao, Jinhai Yu, Tuozhi Huang, Charles Ferguson, Robert G. Parton, Hongyuan Yang, Peng Li
Abstract:Lipid incorporation from the ER to lipid droplets (LDs) influences LD growth and intracellular lipid homeostasis. Xu et al. identify Rab18 as an important regulator of LD dynamics: activated Rab18 binds to ER-associated proteins such as the NRZ complex and SNAREs. The Rab18-NRZ-SNARE complex tethers LDs to the ER, facilitating lipid incorporation and LD growth.
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