1998
DOI: 10.1023/a:1022358313030 View full text |Buy / Rent full text
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Abstract: The initiation of hemodialysis using cuprophane membranes is followed by a rapid fall in the circulating neutrophil count. This neutropenia is caused by a transient sequestration of neutrophils in the lung due to homotypic aggregation, largely in response to generation of C5a by contact of plasma with the dialyzer. The transient nature of hemodialysis neutropenia is due to desensitization of neutrophils to stimulation by C5a, thus demonstrating desensitization in vivo. To examine the in vivo effects on surface… Show more

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“…Tyr 488 of Bgp is phosphorylated in response to activation of the insulin receptor (Margolis et al, 1988;Najjar et al, 1995) and phosphorylation of this residue as well as Ser 503 phosphorylation correlate with e cient bile salt extrusion and insulin receptor endocytosis (Sippel et al, 1994;Formisano et al, 1995). Similarly, Bgp was shown to be Tyr phosphorylated by pp60 c-src in human colonic carcinoma cells (BruÈ mmer et al, 1995) and by p53/56 lyn in human neutrophils (Skubitz et al, 1995).…”
Section: Discussionmentioning
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“…Tyr 488 of Bgp is phosphorylated in response to activation of the insulin receptor (Margolis et al, 1988;Najjar et al, 1995) and phosphorylation of this residue as well as Ser 503 phosphorylation correlate with e cient bile salt extrusion and insulin receptor endocytosis (Sippel et al, 1994;Formisano et al, 1995). Similarly, Bgp was shown to be Tyr phosphorylated by pp60 c-src in human colonic carcinoma cells (BruÈ mmer et al, 1995) and by p53/56 lyn in human neutrophils (Skubitz et al, 1995).…”
Section: Discussionmentioning
“…myeloid cells, which include granulocytes, macrophages, and monocytes [ 18 ], colonic epithelial cells [ 19 ], pneumocytes, bronchiole epithelia [ 20 ], pancreatic ducts, tonsil epithelia [ 21 ], sweat glands [ 22 ], skin and hair follicles [ 23 ], squamous epithelia of the esophagus, cervix and tongue [ 12 ]. Although CEACAM6 and CEACAM7 had very similar expression patterns in normal colonic mucosa, there is opposite deregulation in hyper-proliferating mucosa, adenomas and carcinomas.…”
Section: Ceacam6 Biology Expression and Prognostic Implications In mentioning