“…4 While the positive effects of local agglomeration on knowledge intensive industries might be clear from a theoretical point of view, it is not easy to identify empirically the causal effect of geographical proximity on R&D activity. Starting from the influential work of Acs et al (1993), Jaffe et al (1993), Audretsch and Feldman (1996) and Anselin et al (1997), there is a growing literature identifying the transmission channels from clustered firms to enhanced R&D, innovation activity and finally productivity growth. Acs et al (1993), for instance, estimate production functions for US data and find that, beside standard input factors, the geographical position in a cluster matters strongly.…”