Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides

Aliyu, A. B.; Koorbanally, Neil A.; Moodley, Brenda; Singh, Parvesh; Chenia, Hafizah Y.

doi:10.1016/j.phytochem.2016.02.012

Cited by 44 publications

(33 citation statements)

References 31 publications

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“…For instance, some terpenoids inhibit: (i) the morphogenesis, adhesion, and biofilm formation in Candida albicans as the example of linalool and farnesol [39]; (ii) the biofilm formation and elastase production in P. aeruginosa and Staphylococcus aureus as the example of viridiflorol, ursolic and betulinic acids [40]; or (iii) the production of native auto-inducers acylhomoserine lactones in P. aeruginosa [41] and the QS-controlled violacein production in C. violaceum as the example of the sesquiterpene lactones derivatives [42]. …”

Section: Discussionmentioning

confidence: 99%

Terpenoids from Platostoma rotundifolium (Briq.) A. J. Paton Alter the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1

Rasamiravaka

Ngezahayo

Pottier

et al. 2017

IJMS

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Platostoma rotundifolium (Briq.) A. J. Paton aerial parts are widely used in Burundi traditional medicine to treat infectious diseases. In order to investigate their probable antibacterial activities, crude extracts from P. rotundifolium were assessed for their bactericidal and anti-virulence properties against an opportunistic bacterial model, Pseudomonas aeruginosa PAO1. Whereas none of the tested extracts exert bacteriostatic and/or bactericidal proprieties, the ethyl acetate and dichloromethane extracts exhibit anti-virulence properties against Pseudomonas aeruginosa PAO1 characterized by an alteration in quorum sensing gene expression and biofilm formation without affecting bacterial viability. Bioguided fractionation of the ethyl acetate extract led to the isolation of major anti-virulence compounds that were identified from nuclear magnetic resonance and high-resolution molecular spectroscopy spectra as cassipourol, β-sitosterol and α-amyrin. Globally, cassipourol and β-sitosterol inhibit quorum sensing-regulated and -regulatory genes expression in las and rhl systems without affecting the global regulators gacA and vfr, whereas α-amyrin had no effect on the expression of these genes. These terpenoids disrupt the formation of biofilms at concentrations down to 12.5, 50 and 50 µM for cassipourol, β-sitosterol and α-amyrin, respectively. Moreover, these terpenoids reduce the production of total exopolysaccharides and promote flagella-dependent motilities (swimming and swarming). The isolated terpenoids exert a wide range of inhibition processes, suggesting a complex mechanism of action targeting P. aeruginosa virulence mechanisms which support the wide anti-infectious use of this plant species in traditional Burundian medicine.

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Section: Discussionmentioning

confidence: 99%

Terpenoids from Platostoma rotundifolium (Briq.) A. J. Paton Alter the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1

Rasamiravaka

Ngezahayo

Pottier

et al. 2017

IJMS

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“…CviR is a LuxR receptor protein in C. violaceum ATCC 12472 which is activated by N‐hexanoyl homoserine lactone (C10‐AHL) produced by CviI. Antagonist molecules can bind in place of the natural AHL ligand, inducing the change of CviR conformation to inhibit the DNA binding of CviR and shut down the transcription of CviI and violacein biosynthetical genes . In the present study, we found the treatment of C. violaceum ATCC 12472 with 0.27 mM of compound 10 l consistently down‐regulated CviI and CviR compared to the untreated control.…”

Section: Potential CVI Protein‐compound 10 L Interactionsmentioning

confidence: 63%

Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives

Sun

Chen

et al. 2019

ChemistrySelect

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Naphthyridinone has been reported exhibiting strong antibacterial activity. Now, this study describes a series of novel hydrochloride salts of 5,6,7,8‐tetrahydro‐1,6‐naphthyridin‐2‐(1H)‐one derivatives (10 a–10 l) as potential antibacterial agents and corresponding synthetic routes. The majority of analogues exhibit antibacterial activity against Gram‐negative bacteria (E. coli) and Gram‐positive bacteria (S. aureus). Several of them (10 a, 10 b, 10 h and 10 i) showed strongly antibacterial activity towards E. coli. Compound 10 l is also the first reported compound to exhibit quorum sensing inhibitory activity against C. violaceum ATCC 12472. The presence of quorum sensing inhibitory compound indicates its potential use in the treatment of bacterial infections.

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“…Numerous medicinal plants have been exploited as effective medicines in the fight against drug resistant bacteria [2]. Plant constituents such as essential oils, terpenoids and sesquiterpenoids have been evaluated as potent antibacterial agents on resistant bacteria using novel molecular targets such as inhibitions of efflux pump [3] and quorum sensing [4]. However, drug combination has evolved as a novel strategy to fight resistant bacteria.…”

Section: Introductionmentioning

confidence: 99%

GC-MS Analysis and Antibacterial Effects of Vernonia glaberrima n-Hexane Extracts alone and in Combination with Standard Antibiotics

Gangas¹,

Aliyu²,

Oyewale³

2021

JCSN

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The occurrence of drug resistant bacteria warrant investigation on herbal plants for effective antibacterial agents. Vernonia glaberrima leaf (VGL) and stem (VGS) hexane extracts were subjected to analysis by gas chromatography-mass spectrometry (GC-MS) and subsequently evaluated for antibacterial activity alone and in combination each with Sparfloxacin (SPX) and Ciprofloxacin (CPX) on selected bacteria including resistant species. GC-MS analysis revealed fatty acid esters, triterpenoids and aromatic derivatives largely identified as responsible for the broad-spectrum antibacterial activity. Both the VGL and VGS demonstrated potent antibacterial activities on P. aeruginosa (29 mm and 27 mm), respectively. However, combination of SPX with VGL potentiated the effects on E. coli and S. typhi by synergistic interaction. Similarly, the efficacy of CFX in combination with VGS on MRSA (30 mm) was significantly enhanced by additive action. It was observed that VGS potentiation of CFX on P. aeruginosa (32 mm) was the most effective antibacterial inhibition recorded in the study. Thus, combination of SPX and CFX each with the extracts has revealed remarkable properties for alternative or complementary therapeutic strategy. Our findings elicit enormous potentials of V. glaberrima hexane extracts as treatment adjuncts for combating drug resistant bacteria. It will be interesting to evaluate in vivo effects of extracts in combination with antibiotics against drug resistant bacteria.

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Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides

Cited by 44 publications

References 31 publications

Terpenoids from Platostoma rotundifolium (Briq.) A. J. Paton Alter the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1

Terpenoids from Platostoma rotundifolium (Briq.) A. J. Paton Alter the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1

Synthesis and In Vitro Antibacterial Activity of Novel Naphthyridinone Derivatives

GC-MS Analysis and Antibacterial Effects of Vernonia glaberrima n-Hexane Extracts alone and in Combination with Standard Antibiotics

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