Quorum sensing: a new prospect for the management of antimicrobial-resistant infectious diseases

Haque, Mainul; Islam, Salequl; Sheikh, M.A.; Dhingra, Swati; Uwambaye, Peace; Labricciosa, Francesco M.; Iskandar, Katia; Charan, Jaykaran; Abukabda, Alaeddin B.; Jahan, Dilshad

doi:10.1080/14787210.2021.1843427

Cited by 29 publications

(20 citation statements)

References 220 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, a recent publication from McGill University (in Montreal, Canada) has claimed that a cranberry extract can make the bacteria more sensitive to antibiotic treatment (20). Developing clinically viable quorum sensing inhibitors to supplement existing antimicrobial agents would be another research avenue to pursue (21,22). Finally, the empiric antibacterial therapy during the ongoing COVID-19 pandemic is likely to enhance antibiotic-resistant microorganisms (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Commentary: Microbial Resistance Movements: An Overview of Global Public Health Threats Posed by Antimicrobial Resistance, and How Best to Counter

Razzaque

2021

Front. Public Health

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Commentary: Microbial Resistance Movements: An Overview of Global Public Health Threats Posed by Antimicrobial Resistance, and How Best to Counter

Razzaque

2021

Front. Public Health

View full text Add to dashboard Cite

“…First, detailed studies should be performed on the influence of an AFAMBC on the ability of bacteria to form biofilm on surfaces of alloys currently used to fabricate parts of TJA, such as the stem of a total hip arthroplasty (for example, Ti-6Al-4V and Co-Cr-Mo[ 95 ], and those proposed for such use (for example, Ti-34Nb-2Ta-0.5O[ 96 ], Ti-12Nb-12Zr-12Sn[ 97 ], Ti-13Nb-13Zr[ 98 ], 40Ti-60Ta composite[ 99 ], Ti-39Nb-6Zr-0.45Al[ 100 ], and cold groove-rolled Ti-35Nb-3.75Sn[ 101 ]). Specifically, these studies should focus on determining the effectiveness of an AFAMBC vis a vis biofilms; that is, the extent to which an AFAMBC: (1) Inhibits microbial adhesion to the surface and colonization; (2) Interferes with the signal molecules that modulate biofilm formation (and associated increased antibiotic tolerance) (for example, quorum sensing inhibitors and/or quorum quenching agents[ 102 - 105 ]; and (3) Disaggregates the biofilm matrix[ 89 , 90 , 92 , 93 , 104 - 110 ].…”

Section: Future Prospectsmentioning

confidence: 99%

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Lewis¹

2022

WJO

View full text Add to dashboard Cite

Prosthetic joint infection (PJI) is the most serious complication following total joint arthroplasty, this being because it is associated with, among other things, high morbidity and low quality of life, is difficult to prevent, and is very challenging to treat/manage. The many shortcomings of antibiotic-loaded poly (methyl methacrylate) (PMMA) bone cement (ALBC) as an agent for preventing and treating/managing PJI are well-known. One is that microorganisms responsible for most PJI cases, such as methicillin-resistant S. aureus , have developed or are developing resistance to gentamicin sulfate, which is the antibiotic in the vast majority of approved ALBC brands. This has led to many research efforts to develop cements that do not contain gentamicin (or, for that matter, any antibiotic) but demonstrate excellent antimicrobial efficacy. There is a sizeable body of literature on these so-called “antibiotic-free antimicrobial” PMMA bone cements (AFAMBCs). The present work is a comprehensive and critical review of this body. In addition to summaries of key trends in results of characterization studies of AFAMBCs, the attractive features and shortcomings of the literature are highlighted. Shortcomings provide motivation for future work, with some ideas being formulation of a new generation of AFAMBCs by, example, adding a nanostructured material and/or an extract from a natural product to the powder and/or liquid of the basis cement, respectively.

show abstract

“…When the QS system of bacteria is blocked, bacteria cannot communicate with the surrounding environment and failed to infect the host plant. Interestingly, some marine natural compounds can also target and interrupt the bacterial QS system to prevent infection of the bacterial pathogens [149,150]. For example, 2-methyl-n-(2'-phenylethyl)-butanamide and 3-methyl-n-(2'-phenylethyl)-butanamide, two marine-derived compounds, can destroy the QS system of rice pathogenic bacterium B. glumae (ATCC 333,617), therefore interrupt virulence feature production, including proteases, toxins, as well as some other immuneevasion factors [23].…”

Section: Affect Bacterial Qs Systemmentioning

confidence: 99%

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Zhao

Chen

2021

Marine Drugs

View full text Add to dashboard Cite

Plant diseases have been threatening food production. Controlling plant pathogens has become an important strategy to ensure food security. Although chemical control is an effective disease control strategy, its application is limited by many problems, such as environmental impact and pathogen resistance. In order to overcome these problems, it is necessary to develop more chemical reagents with new functional mechanisms. Due to their special living environment, marine organisms have produced a variety of bioactive compounds with novel structures, which have the potential to develop new fungicides. In the past two decades, screening marine bioactive compounds to inhibit plant pathogens has been a hot topic. In this review, we summarize the screening methods of marine active substances from plant pathogens, the identification of marine active substances from different sources, and the structure and antibacterial mechanism of marine active natural products. Finally, the application prospect of marine bioactive substances in plant disease control was prospected.

show abstract

Quorum sensing: a new prospect for the management of antimicrobial-resistant infectious diseases

Cited by 29 publications

References 220 publications

Commentary: Microbial Resistance Movements: An Overview of Global Public Health Threats Posed by Antimicrobial Resistance, and How Best to Counter

Commentary: Microbial Resistance Movements: An Overview of Global Public Health Threats Posed by Antimicrobial Resistance, and How Best to Counter

Antibiotic-free antimicrobial poly (methyl methacrylate) bone cements: A state-of-the-art review

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Contact Info

Product

Resources

About