In this note we study refined BPS invariants associated with certain quantum line defects in quantum field theories of class S. Such defects can be specified via geometric engineering in the UV by assigning a path on a certain curve. In the IR they are described by framed BPS quivers. We study the associated BPS spectral problem, including the spin content. The relevant BPS invariants arise from the K-theoretic enumerative geometry of the moduli spaces of quiver representations, adapting a construction by Nekrasov and Okounkov. In particular refined framed BPS states are described via Euler characteristics of certain complexes of sheaves.