Quinone analogues regulate mitochondrial substrate competitive oxidation

Brière, Jean-Jacques; Schlemmer, Dimitri; Chretien, Domique; Rustin, Pierre

doi:10.1016/j.bbrc.2004.03.002

Cited by 64 publications

(49 citation statements)

References 17 publications

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“…It is well known that quinones considerably influence mitochondrial function (5,20,21,26,51). Reduction of quinone by mitochondrial ETC complexes or DT-diaphorase can result in formation of semi-or dihydro-forms of quinone molecules.…”

Section: Discussionmentioning

confidence: 99%

“…Quinones can be reduced according to one-or twoelectron mechanisms by intracellular reductases, including mitochondrial NADH:ubiquinone oxidoreductase, and the mitochondrial isoform of DT-diaphorase (NAD(P)H: quinone oxidoreductase 1 (NQO1) (29,(38)(39)(40). Quinones can recapture electrons from ubiquinol of the mitochondrial ETC and influence the electron flow between ETC dehydrogenases (5,10,11,31). Quinone's ability to interact with ETC components depends on the lipophilic properties of a quinone (5,11,31).…”

Section: Introductionmentioning

confidence: 99%

“…Quinones can recapture electrons from ubiquinol of the mitochondrial ETC and influence the electron flow between ETC dehydrogenases (5,10,11,31). Quinone's ability to interact with ETC components depends on the lipophilic properties of a quinone (5,11,31).…”

Section: Introductionmentioning

confidence: 99%

“…It was shown that 1,4-benzoquinone, 1,4-naphthoquinone, and their derivatives decreased the mitochondrial membrane potential in cells and calcium-loaded isolated mitochondria. This effect is related to mitochondrial permeability transition pore opening caused by quinone-induced ROS generation and/or by arylation of SH─ groups of proteins participating in pore formation (5,20,21,24,26,41,51). Menadione, duroquinone, and coenzyme Q 1 are capable of recovering respiratory and phosphorylating mitochondrial functions shunting ETC complexes during rotenone inhibition of respiration.…”

Section: Introductionmentioning

confidence: 99%

“…Being reduced by mitochondrial DT-diaphorase, these quinones either can transfer electrons directly to Complex III, coenzyme Q, or they can play a role of succinate dehydrogenase substrates (9,10,13,23,37). Quinone derivatives are among rare compounds successfully used as therapeutic agents to treat mitochondrial diseases (5,9) and bypass the damaged sites in mitochondria. To reveal the dependence of quinone mitochondrial effects on their physicochemical properties, the group of quinones varying in lipophilicity and one-electron reduction potential E 1/2 was studied.…”

Section: Introductionmentioning

confidence: 99%

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Redox regulation of mitochondrial functional activity by quinones

et al. 2016

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Quinones are among the rare compounds successfully used as therapeutic agents to correct mitochondrial diseases and as specific regulators of mitochondrial function within cells. The aim of the present study was to elucidate the redox-dependent effects of quinones on mitochondrial function. The functional parameters [respiratory activity, membrane potential, and reactive oxygen species (ROS) generation] of isolated rat liver mitochondria and mitochondria in intact cells were measured in the presence of eight exogenously applied quinones that differ in lipophilicity and one-electron reduction potential. The quinones affected the respiratory parameters of mitochondria, and dissipated the mitochondrial membrane potential as well as influenced (either decreased or enhanced) ROS generation, and restored the electron flow during electron transport chain inhibition. The stimulation of ROS production by juglone and 2,5-di-tert-butyl-1,4-benzoquinone was accompanied by a decrease in the acceptor control and respiration control ratios, dissipation of the mitochondrial membrane potential and induction of the reverse electron flow under succinate oxidation in isolated mitochondria. Menadione and 2,3,5-trimethyl-1,4-benzoquinone, which decreased the mitochondrial ROS generation, did not affect the mitochondrial potential and, vice versa, were capable of restoring electron transport during Complex I inhibition. In intact C6 cells, all the quinones, except for coenzyme Q 10 , decreased the mitochondrial membrane potential. Juglone, 1,4-benzoquinone, and menadione showed the most pronounced effects. These findings indicate that quinones with the reduction potential values E 1/2 in the range from −99 to −260 mV were effective redox regulators of mitochondrial electron transport.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Redox regulation of mitochondrial functional activity by quinones

et al. 2016

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Total Synthesis of (+)‐Dibromophakellin and (+)‐Dibromophakellstatin

Imaoka

Akimoto

Iwamoto

et al. 2010

Chemistry An Asian Journal

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Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP

2007

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Decylubiquinone treatment in vitro has demonstrated a potent inhibitor effect on reactive oxidative species production. However, the effectin vivo has not been demonstrated yet. Thus, rats SHRSP male were divided in two groups: treated and controls (n=6, each). The treated group received 10 mg/Kg(-)/body weight of decylubiquinone diluted in coconut oil by oral gavage during four weeks. Control rats just received the vehicle. Body weight, diuresis, food and water intake, systolic blood pressure, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, blood glucose levels and malondialdehyde were determined. There were a significant (p<0.05) reduction on systolic blood pressure, plasma malondialdehyde, total cholesterol and LDL-cholesterol in the treated group. Additionally, HDL-cholesterol also increased significantly. However, body weight, diuresis, food and water intake, blood glucose levels and triglycerides did not alter after treatment. Thus, decylubiquinone can be a new antihypertensive, hypolipidemic and antioxidant agent on the prevention and treatment of diseases linked to oxidative stress.

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Quinone analogues regulate mitochondrial substrate competitive oxidation

Cited by 64 publications

References 17 publications

Redox regulation of mitochondrial functional activity by quinones

Redox regulation of mitochondrial functional activity by quinones

Total Synthesis of (+)‐Dibromophakellin and (+)‐Dibromophakellstatin

Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP

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