Quinoclamine inhibits Shiga toxin production in enterohemorrhagicEscherichia coli
Oiti Kar,
Hsiao-Cheng Feng,
Hiroyuki Hirano
et al.
Abstract:ObjectivesEnterohemorrhagicEscherichia coli(EHEC) is responsible for the most severe symptoms ofE. coliinfections, including hemorrhagic colitis and hemorrhagic uremic syndrome. Shiga toxin 2 (Stx2) plays a significant role as a major virulence factor. The genes encoding Stx2 locate in lambda-like prophage on the EHEC genome. Consequently, Stx2 is expressed when production of the phage is induced by the SOS response. Antibiotic treatment is not recommended for curing the bacterial infection, because it is asso… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.