Quinine-Induced Tinnitus in Rats

Comparison of Salicylate- and Quinine-Induced Tinnitus in Rats

“…Our results differ from those of previous studies that found evidence of tinnitus in rats treated with 200 mg/kg of quinine given subcutaneously (15). The differences between our results and those of previous studies could be explained by the route of quinine administration or attributed to the differences in behavioral paradigms used to assess tinnitus.…”

“…Both drugs are known to induce transient tinnitus that lasts for the duration of the treatment period and for a short period of time afterwards (~24-48 h). Previous studies suggest that the pitch of salicylate-induced tinnitus occurs between 10 and 16 kHz (16, 30); quinine has been reported to induce a lower-pitch tinnitus (15, 16). …”

Comparison of Salicylate- and Quinine-Induced Tinnitus in Rats

“…Our results differ from those of previous studies that found evidence of tinnitus in rats treated with 200 mg/kg of quinine given subcutaneously (15). The differences between our results and those of previous studies could be explained by the route of quinine administration or attributed to the differences in behavioral paradigms used to assess tinnitus.…”

“…Both drugs are known to induce transient tinnitus that lasts for the duration of the treatment period and for a short period of time afterwards (~24-48 h). Previous studies suggest that the pitch of salicylate-induced tinnitus occurs between 10 and 16 kHz (16, 30); quinine has been reported to induce a lower-pitch tinnitus (15, 16). …”

Salicylate-induced phantom auditory effects on reinforced behavior in pre- and postweanling rats

“…We have since completed a fairly extensive study in which dose levels were systematically related to the extent of the salicylate-induced effect (Jastreboff & Brennan, 1992); the dose threshold level producing reliable behavioral effects in adults was between 100 and 150 mg/kg. Moreover, we have replicated the basic findings with quinine, also known to have auditory effects in humans (Jastreboff, Brennan, & Sasaki, 1991). With both salicylate and quinine, the drug-induced effects were resistant to changes in motivation and variation in the auditory background of subjects.…”

Attenuation of Salicylate-lnduced Tinnitus by Ginkgo biloba Extract in Rats

“…This, however, does not preclude a study of tinnitus, provid ing that we can be reasonably sure that the ani mals indeed experience tinnitus after salicy late administration. Results published since 1987 support the hypothesis that animals in deed perceive tinnitus after administration of salicylate or quinine and that the extent of behavioral manifestation of tinnitus depends on the drug dose [23,24]. The main findings supporting the validity of the model arc [20]: (1) The effect of daily drug administration depend in a contrasting manner (facilitation vs. deepening of the suppression) on the stage of training when a drug was introduced.…”

Comparison of Salicylate- and Quinine-Induced Tinnitus in Rats

“…Our results differ from those of previous studies that found evidence of tinnitus in rats treated with 200 mg/kg of quinine given subcutaneously (15). The differences between our results and those of previous studies could be explained by the route of quinine administration or attributed to the differences in behavioral paradigms used to assess tinnitus.…”

“…Both drugs are known to induce transient tinnitus that lasts for the duration of the treatment period and for a short period of time afterwards (~24-48 h). Previous studies suggest that the pitch of salicylate-induced tinnitus occurs between 10 and 16 kHz (16, 30); quinine has been reported to induce a lower-pitch tinnitus (15, 16). …”

Salicylate-induced phantom auditory effects on reinforced behavior in pre- and postweanling rats

“…We have since completed a fairly extensive study in which dose levels were systematically related to the extent of the salicylate-induced effect (Jastreboff & Brennan, 1992); the dose threshold level producing reliable behavioral effects in adults was between 100 and 150 mg/kg. Moreover, we have replicated the basic findings with quinine, also known to have auditory effects in humans (Jastreboff, Brennan, & Sasaki, 1991). With both salicylate and quinine, the drug-induced effects were resistant to changes in motivation and variation in the auditory background of subjects.…”

Attenuation of Salicylate-lnduced Tinnitus by Ginkgo biloba Extract in Rats

“…This, however, does not preclude a study of tinnitus, provid ing that we can be reasonably sure that the ani mals indeed experience tinnitus after salicy late administration. Results published since 1987 support the hypothesis that animals in deed perceive tinnitus after administration of salicylate or quinine and that the extent of behavioral manifestation of tinnitus depends on the drug dose [23,24]. The main findings supporting the validity of the model arc [20]: (1) The effect of daily drug administration depend in a contrasting manner (facilitation vs. deepening of the suppression) on the stage of training when a drug was introduced.…”

Comparison of Salicylate- and Quinine-Induced Tinnitus in Rats

“…Our results differ from those of previous studies that found evidence of tinnitus in rats treated with 200 mg/kg of quinine given subcutaneously (15). The differences between our results and those of previous studies could be explained by the route of quinine administration or attributed to the differences in behavioral paradigms used to assess tinnitus.…”

“…Both drugs are known to induce transient tinnitus that lasts for the duration of the treatment period and for a short period of time afterwards (~24-48 h). Previous studies suggest that the pitch of salicylate-induced tinnitus occurs between 10 and 16 kHz (16, 30); quinine has been reported to induce a lower-pitch tinnitus (15, 16). …”

Salicylate-induced phantom auditory effects on reinforced behavior in pre- and postweanling rats

“…We have since completed a fairly extensive study in which dose levels were systematically related to the extent of the salicylate-induced effect (Jastreboff & Brennan, 1992); the dose threshold level producing reliable behavioral effects in adults was between 100 and 150 mg/kg. Moreover, we have replicated the basic findings with quinine, also known to have auditory effects in humans (Jastreboff, Brennan, & Sasaki, 1991). With both salicylate and quinine, the drug-induced effects were resistant to changes in motivation and variation in the auditory background of subjects.…”

Attenuation of Salicylate-lnduced Tinnitus by Ginkgo biloba Extract in Rats

“…This, however, does not preclude a study of tinnitus, provid ing that we can be reasonably sure that the ani mals indeed experience tinnitus after salicy late administration. Results published since 1987 support the hypothesis that animals in deed perceive tinnitus after administration of salicylate or quinine and that the extent of behavioral manifestation of tinnitus depends on the drug dose [23,24]. The main findings supporting the validity of the model arc [20]: (1) The effect of daily drug administration depend in a contrasting manner (facilitation vs. deepening of the suppression) on the stage of training when a drug was introduced.…”