Quinine for muscle cramps

EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force

“…Quinine sulphate has been banned by the FDA because of safety concerns [92]. However, a recent Cochrane Review in non‐ALS cramps found quinine sulphate to be effective with no difference serious adverse events between the placebo and active drug [93]. Treatments such as massage, physical exercise, hydrotherapy in heated pools, carbamazepine, diazepam, phenytoin and verapamil have been tried, but there are no controlled studies in ALS.…”

EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force

“…Quinine sulphate has been banned by the FDA because of safety concerns [92]. However, a recent Cochrane Review in non‐ALS cramps found quinine sulphate to be effective with no difference serious adverse events between the placebo and active drug [93]. Treatments such as massage, physical exercise, hydrotherapy in heated pools, carbamazepine, diazepam, phenytoin and verapamil have been tried, but there are no controlled studies in ALS.…”

Systematic review: the treatment of muscle cramps in patients with cirrhosis

“…Quinine is extracted from the cinchona tree in the Andes region of South America. It reduces the muscle response to repetitive stimulation and the excitability of motor end plates and has been shown to have a similar effect on muscles and neuromuscular junctions as curare . One randomised‐controlled trial investigated the use of quinidine in the treatment of cirrhotic patients with painful muscle cramps .…”

Quinine Sulfate for Muscle Cramps in Amyotrophic Lateral Sclerosis: A Randomized, Double‐Blind Crossover Trial

“…A Cochrane review [8] reported that quinine reduced cramp intensity by 10% and frequency by 28% in idiopathic muscle cramps, demonstrating a modest benefit. In contrast, our study in ALS patients showed a 48% reduction in cramp intensity and a 53% reduction in frequency, suggesting a greater effect on muscle cramps in the ALS population.…”

EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force

“…Quinine sulphate has been banned by the FDA because of safety concerns [92]. However, a recent Cochrane Review in non‐ALS cramps found quinine sulphate to be effective with no difference serious adverse events between the placebo and active drug [93]. Treatments such as massage, physical exercise, hydrotherapy in heated pools, carbamazepine, diazepam, phenytoin and verapamil have been tried, but there are no controlled studies in ALS.…”

Systematic review: the treatment of muscle cramps in patients with cirrhosis

“…Quinine is extracted from the cinchona tree in the Andes region of South America. It reduces the muscle response to repetitive stimulation and the excitability of motor end plates and has been shown to have a similar effect on muscles and neuromuscular junctions as curare . One randomised‐controlled trial investigated the use of quinidine in the treatment of cirrhotic patients with painful muscle cramps .…”

Quinine Sulfate for Muscle Cramps in Amyotrophic Lateral Sclerosis: A Randomized, Double‐Blind Crossover Trial

“…A Cochrane review [8] reported that quinine reduced cramp intensity by 10% and frequency by 28% in idiopathic muscle cramps, demonstrating a modest benefit. In contrast, our study in ALS patients showed a 48% reduction in cramp intensity and a 53% reduction in frequency, suggesting a greater effect on muscle cramps in the ALS population.…”

EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force

“…Quinine sulphate has been banned by the FDA because of safety concerns [92]. However, a recent Cochrane Review in non‐ALS cramps found quinine sulphate to be effective with no difference serious adverse events between the placebo and active drug [93]. Treatments such as massage, physical exercise, hydrotherapy in heated pools, carbamazepine, diazepam, phenytoin and verapamil have been tried, but there are no controlled studies in ALS.…”

Systematic review: the treatment of muscle cramps in patients with cirrhosis

“…Quinine is extracted from the cinchona tree in the Andes region of South America. It reduces the muscle response to repetitive stimulation and the excitability of motor end plates and has been shown to have a similar effect on muscles and neuromuscular junctions as curare . One randomised‐controlled trial investigated the use of quinidine in the treatment of cirrhotic patients with painful muscle cramps .…”

Quinine Sulfate for Muscle Cramps in Amyotrophic Lateral Sclerosis: A Randomized, Double‐Blind Crossover Trial

“…A Cochrane review [8] reported that quinine reduced cramp intensity by 10% and frequency by 28% in idiopathic muscle cramps, demonstrating a modest benefit. In contrast, our study in ALS patients showed a 48% reduction in cramp intensity and a 53% reduction in frequency, suggesting a greater effect on muscle cramps in the ALS population.…”