Eur. J. Chem. volume 6, issue 3, P254-260 2015 DOI: 10.5155/eurjchem.6.3.254-260.1233
Kadalipura Puttaswamy Rakesh, Suhas Ramesh, Honnayakanahalli Marichennegowda Kumar, Shivamallu Chandan, Dase Channe Gowda
Abstract:

Two series of amino acids conjugated quinazolinones (1a-h and 2a-h) were synthesized by acid-amine coupling and the structures of all the compounds were confirmed through spectroscopic techniques such as IR, NMR and HRMS. The synthesized compounds were evaluated for their antimicrobial, antioxidant and anti-inflammatory activities. Biological evaluation study revealed that, the compounds 1f, 2f, 2g and 1g showed good antioxidant activity with 50% of the inhibition concentration (IC50) values 35, 20, 30 and…

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