Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal

Amer, Sandra Sherif; Mamdouh, Wael; Nasr, Maha; ElShaer, Amr; Polycarpou, Elena; Abdel-Aziz, Rasha T A; Sammour, Omaima A.

doi:10.1016/j.ijpharm.2021.121309

Cited by 27 publications

(22 citation statements)

References 79 publications

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“…Acne vulgaris is a prevalent dermatological disease that affects more than 80% of adolescents. It is commonly spread in the areas of the pilosebaceous gland (oil glands accompanied by hair follicles on the face, neck, shoulders, chest, and back) [ 1 ]. In the aspect of its clinical manifestations, it is depicted by the existence of various types of skin lesions which are inflammatory or non-inflammatory and sometimes turn out to be more severe showing papules, pustules, nodules, or cysts [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is commonly spread in the areas of the pilosebaceous gland (oil glands accompanied by hair follicles on the face, neck, shoulders, chest, and back) [ 1 ]. In the aspect of its clinical manifestations, it is depicted by the existence of various types of skin lesions which are inflammatory or non-inflammatory and sometimes turn out to be more severe showing papules, pustules, nodules, or cysts [ 1 ]. Remarkably, it is caused by altered keratinization, androgen-induced sebum, inflammation, and Propionibacterium acnes ( P. acne ) colonization [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

et al. 2023

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The foremost target of the current work was to formulate and optimize a novel bergamot essential oil (BEO) loaded nano-phytosomes (NPs) and then combine it with spironolactone (SP) in order to clinically compare the efficiency of both formulations against acne vulgaris. The BEO-loaded NPs formulations were fabricated by the thin-film hydration and optimized by 32 factorial design. NPs’ assessments were conducted by measuring entrapment efficiency percent (EE%), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). In addition, the selected BEO-NPs formulation was further combined with SP and then examined for morphology employing transmission electron microscopy and three months storage stability. Both BEO-loaded NPs selected formula and its combination with SP (BEO-NPs-SP) were investigated clinically for their effect against acne vulgaris after an appropriate in silico study. The optimum BEO-NPs-SP showed PS of 300.40 ± 22.56 nm, PDI of 0.571 ± 0.16, EE% of 87.89 ± 4.14%, and an acceptable ZP value of −29.7 ± 1.54 mV. Molecular modeling simulations showed the beneficial role of BEO constituents as supportive/connecting platforms for favored anchoring of SP on the Phosphatidylcholine (PC) interface. Clinical studies revealed significant improvement in the therapeutic response of BEO-loaded NPs that were combined with SP over BEO-NPs alone. In conclusion, the results proved the ability to utilize NPs as a successful nanovesicle for topical BEO delivery as well as the superior synergistic effect when combined with SP in combating acne vulgaris.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

et al. 2023

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“…Precisely, for quercetin dihydrate it was reported that no melting occurred prior decomposition and that at 116 °C decomposition related to water loss occurred [ 12 ]. In other studies for quercetin, various similar values have been reported for the melting point, e.g., a melting point at 315 °C with a heat of fusion of 51.08 kJ/mol along with glass transition at 108 °C [ 19 ], a melting point of 326.7 °C [ 20 ], a melting point of 322 °C with a heat of fusion of 41.5 kJ/mol [ 21 ], and, very recently, a melting point of 323 °C [ 22 ]. As a summary, the transitions of quercetin at low temperatures (around 100 °C) have been attributed to various different effects, such as dehydration/decomposition or glass transition, while the transition at higher temperatures (around 320 °C) is typically attributed to melting.…”

Section: Introductionmentioning

confidence: 99%

On the Thermodynamic Thermal Properties of Quercetin and Similar Pharmaceuticals

Tsioptsias

Tsivintzelis

2022

Molecules

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The thermodynamic properties of pharmaceuticals are of major importance since they are involved in drug design, processing, optimization and modelling. In this study, a long-standing confusion regarding the thermodynamic properties of flavonoids and similar pharmaceuticals is recognized and clarified. As a case study, the thermal behavior of quercetin is examined with various techniques. It is shown that quercetin does not exhibit glass transition nor a melting point, but on the contrary, it does exhibit various thermochemical transitions (structural relaxation occurring simultaneously with decomposition). Inevitably, the physical meaning of the reported experimental values of the thermodynamic properties, such as the heat of fusion and heat capacity, are questioned. The discussion for this behavior is focused on the weakening of the chemical bonds. The interpretations along with the literature data suggest that the thermochemical transition might be exhibited by various flavonoids and other similar pharmaceuticals, and is related to the difficulty in the prediction/modelling of their melting point.

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“…It was converted into quercetin nanofibres, which have a large porous surface area and contain many active compounds that can easily penetrate through the skin. These quercetin patches showed antibacterial activity against Cutibacterium acnes , safety for skin fibroblasts, and promising efficacy in clinical trials [ 42 ]. Film- and foamlike structures of N-carboxybutylchitosan (CBC) and agarose were prepared and characterised to investigate their potential application as topical membranous wound dressings.…”

Section: Therapeutic Strategies Of Skin Infections and Wound Healingmentioning

confidence: 99%

Prenylated Flavonoids in Topical Infections and Wound Healing

et al. 2022

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The review presents prenylated flavonoids as potential therapeutic agents for the treatment of topical skin infections and wounds, as they can restore the balance in the wound microenvironment. A thorough two-stage search of scientific papers published between 2000 and 2022 was conducted, with independent assessment of results by two reviewers. The main criteria were an MIC (minimum inhibitory concentration) of up to 32 µg/mL, a microdilution/macrodilution broth method according to CLSI (Clinical and Laboratory Standards Institute) or EUCAST (European Committee on Antimicrobial Susceptibility Testing), pathogens responsible for skin infections, and additional antioxidant, anti-inflammatory, and low cytotoxic effects. A total of 127 structurally diverse flavonoids showed promising antimicrobial activity against pathogens affecting wound healing, predominantly Staphylococcus aureus strains, but only artocarpin, diplacone, isobavachalcone, licochalcone A, sophoraflavanone G, and xanthohumol showed multiple activity, including antimicrobial, antioxidant, and anti-inflammatory along with low cytotoxicity important for wound healing. Although prenylated flavonoids appear to be promising in wound therapy of humans, and also animals, their activity was measured only in vitro and in vivo. Future studies are, therefore, needed to establish rational dosing according to MIC and MBC (minimum bactericidal concentration) values, test potential toxicity to human cells, measure healing kinetics, and consider formulation in smart drug release systems and/or delivery technologies to increase their bioavailability.

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Quercetin loaded cosm-nutraceutical electrospun composite nanofibers for acne alleviation: Preparation, characterization and experimental clinical appraisal

Cited by 27 publications

References 79 publications

Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation

On the Thermodynamic Thermal Properties of Quercetin and Similar Pharmaceuticals

Prenylated Flavonoids in Topical Infections and Wound Healing

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