Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential

Mittal, Amit Kumar; Kumar, Sanjay; Banerjee, Uttam Chand

doi:10.1016/j.jcis.2014.06.030

Cited by 228 publications

(111 citation statements)

References 33 publications

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“…The absorption spectra showed a maximum peak at 420 nm, which represents the characteristic peak for AgNPs (Figure 1A). Our results are consistent with previous report by Mittal et al (2014) [34], who utilized quercetin as a reducing and stabilizing agent for AgNPs synthesis. Next, we examined the crystal structure of AgNPs using X-ray diffraction (XRD).…”

Section: Resultssupporting

confidence: 93%

“…XRD spectra showed that the crystalline structure of AgNPs has two distinct diffraction peaks at 35.28° and 44.33° corresponding to lattice plane value indexed at (111), and (200), planes of face centered cubic structure silver. These results are consistent with the properties of AgNPs previously prepared using various biomolecules, such as culture supernatants of Bacillus licheniformis , E. coli , purified fibrinolytic URAK, and quercetin [34,35,36,37]. Further validation was carried out using Fourier transform infrared (FTIR) spectroscopy, which is useful for determining the chemical composition of reactants involved in the synthesis and coating of AgNPs.…”

Section: Resultssupporting

confidence: 82%

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Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy

Yuan

Peng

Gurunathan

2017

IJMS

257

177

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Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. Microorganisms generally acquire resistance to antibiotics through the course of antibacterial therapy. Multi-drug resistance (MDR) has become a growing problem in the treatment of infectious diseases, and the widespread use of broad-spectrum antibiotics has resulted in the development of antibiotic resistance by numerous human and animal bacterial pathogens. As a result, an increasing number of microorganisms are resistant to multiple antibiotics causing continuing economic losses in dairy farming. Therefore, there is an urgent need for the development of alternative, cost-effective, and efficient antimicrobial agents that overcome antimicrobial resistance. Here, AgNPs synthesized using the bio-molecule quercetin were characterized using various analytical techniques. The synthesized AgNPs were highly spherical in shape and had an average size of 11 nm. We evaluated the efficacy of synthesized AgNPs against two MDR pathogenic bacteria, namely, Pseudomonas aeruginosa and Staphylococcus aureus, which were isolated from milk samples produced by mastitis-infected goats. The minimum inhibitory concentrations (MICs) of AgNPs against P. aeruginosa and S. aureus were found to be 1 and 2 μg/mL, respectively. Our findings suggest that AgNPs exert antibacterial effects in a dose- and time-dependent manner. Results from the present study demonstrate that the antibacterial activity of AgNPs is due to the generation of reactive oxygen species (ROS), malondialdehyde (MDA), and leakage of proteins and sugars in bacterial cells. Results of the present study showed that AgNP-treated bacteria had significantly lower lactate dehydrogenase activity (LDH) and lower adenosine triphosphate (ATP) levels compared to the control. Furthermore, AgNP-treated bacteria showed downregulated expression of glutathione (GSH), upregulation of glutathione S-transferase (GST), and downregulation of both superoxide dismutase (SOD) and catalase (CAT). These physiological and biochemical measurements were consistently observed in AgNP-treated bacteria, thereby suggesting that AgNPs can induce bacterial cell death. Thus, the above results represent conclusive findings on the mechanism of action of AgNPs against different types of bacteria. This study also demonstrates the promising use of nanoparticles as antibacterial agents for use in the biotechnology and biomedical industry. Furthermore, this study is the first to propose the mode of action of AgNPs against MDR pathogens isolated from goats infected with subclinical mastitis.

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 82%

Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy

Yuan

Peng

Gurunathan

2017

IJMS

257

177

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“…Flavonoids are capable of altering the kinetics of lipid peroxidation by modifying the organization of lipid compounds (MITTAL et al, 2014). Flavonoids have ideal structures for the sequestration of free radicals, being considered antioxidants more effective than vitamins E and C (BARREIROS et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

et al. 2017

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-Cerrado is the largest biome in the state of Minas Gerais-Brazil, represented by a biodiversity of fruit species, especially cagaita (Eugenia dysenterica). Cagaita fruits are considered an important option for fruit growing, because they are source of phenolic compounds with antioxidant properties and mineral content that can contribute with beneficial health effects. In this study, phenolic compounds were characterized by high-performance liquid chromatography and the mineral content of ripe and unripe cagaita fruits was evaluated. Regarding minerals, ripe and unripe fruits stand out due to their high potassium content. Unripe fruits are rich in boron while ripe fruits are source of this mineral. ripe and unripe cagaita fruits have the following phenolic compounds: gallic, caffeic, vanillic, p-coumaric, siringeic, ferulic and salicylic acids, epicatechin, quercetin and rutin, the highest contents of these compounds are caffeic, p-coumaric, siringeic and ferrulic, epicatechin and rutin identified in unripe fruits, while ripe fruits have high contents of gallic, vanillic and quercetin acids. Thus, cagaita fruits have great potential for food, therapeutic and medicinal applications bringing health benefits. Index terms: Cerrado fruits, Myrtaceae, HPLC-Uv. MINERAIS E COMPOSTOS FENÓLICOS EM DIFERENTES ESTÁDIOS DE MATURAÇÃO DE FRUTOS DE CAGAITEIRA (Eugenia dysenterica)RESUMO -O Cerrado é o maior bioma no Estado de Minas Gerais-Brasil, representado uma biodiversidade de espécies frutíferas, destacando a cagaiteira (Eugenia dysenterica). Frutos de cagaiteira são considerados uma opção importante para fruticultura, por apresentarem fonte de compostos fenólicos com propriedades antioxidantes e teores de minerais que podem contribuir com efeitos benéficos à saúde. Neste estudo, caracterizaram-se os compostos fenólicos por cromatografia líquida de alta eficiência e avaliaram-se os teores de minerais presentes em frutos de cagaiteira em estádio de maturação maduros e verdes. Em relação aos minerais, frutos maduros e verdes destacam-se por serem ricos em potássio. Os frutos verdes são ricos em boro, enquanto os frutos maduros são fonte desse mineral. Nos frutos de cagaiteira maduros e verdes, foram identificados os compostos fenólicos: os ácidos gálico, cafeico, vanílico, p-cumárico, siríngico, ferúlico e salicílico, epicatequina, quercetina e rutina, sendo os maiores teores dos compostos os ácidos cafeico, p-cumárico, siríngico e ferúlico, epicatequina e rutina identificados nos frutos verdes, enquanto para frutos maduros o destaque foi para os ácidos gálico, vanílico esalicílico e quercetina. Assim, frutos de cagaita podem apresentar grande potencial para aplicações alimentares, terapêuticas e medicinais, trazendo benefícios à saúde. Termos de indexação:Frutos do cerrado, Myrtaceae, CLAE-Uv.

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“…The z-average size of the nanoparticles was about 251.8 ± 26.3 nm. The variation noted in the average particle size measured by DLS and TEM is accounted for hydrodynamic radius calculated by DLS in contrast to true particle radius provided by TEM (Mittal et al, 2014;Srivastava and Mukhopadhyay, 2013). The zeta potential of the synthesized selenium nanoparticles suspended in MilliQ water was found to be À39.9 ± 5.3 mV [ Supplementary Fig.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Biomimetic synthesis of selenium nanoparticles by Pseudomonas aeruginosa ATCC 27853: An approach for conversion of selenite

Kora

Rastogi

2016

Journal of Environmental Management

114

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Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential

Cited by 228 publications

References 33 publications

Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy

Effects of Silver Nanoparticles on Multiple Drug-Resistant Strains of Staphylococcus aureus and Pseudomonas aeruginosa from Mastitis-Infected Goats: An Alternative Approach for Antimicrobial Therapy

MINERALS AND PHENOLIC COMPOUNDS OF CAGAITA FRUITS AT DIFFERENT MATURATION STAGES (Eugenia dysenterica)

Biomimetic synthesis of selenium nanoparticles by Pseudomonas aeruginosa ATCC 27853: An approach for conversion of selenite

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