The quark mean-field (QMF) model is applied to study the single Λ + c hypernuclei. The charm baryon, Λ + c , is constructed by three constituent quarks, u, d, and c, confined by central harmonic oscillator potentials. The confinement potential strength of charm quark is determined by fitting the experimental masses of charm baryons, Λ + c , Σ + c , and Ξ ++ cc . The effects of pions and gluons are also considered to describe the baryons at the quark level. The baryons in Λ + c hypernuclei interact with each other through exchanging the σ, ω, and ρ mesons between the quarks confined in different baryons. The Λ + c N potential in the QMF model is strongly dependent on the coupling constant between ω meson and Λ + c , g ωΛ + c . When the conventional quark counting rule is used, i. e., g ωΛ + c = 2/3g ωN , the massive Λ + c hypernucleus can exist, whose single Λ + c binding energy is smaller with the mass number increasing due to the strong Coulomb repulsion between Λ + c and protons. When g ωΛ + c is fixed by the latest lattice Λ + c N potential, the Λ + c hypernuclei only can exist up to A ∼ 50.