Quantitative ultrasound bone measurements: Normal values and comparison with bone mineral density by dual X-ray absorptiometry

Moris, Marielle; Peretz, Anne; Tjeka, R.; Negaban, N; Wouters, Mira M.; Bergmann, Pierre

doi:10.1007/bf00298988

Cited by 90 publications

(47 citation statements)

References 39 publications

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“…In our study, we examined whether gait speed predicts SOS values. Calcaneus measurements based on ultrasound and dual-energy X-ray absorptiometry (DXA) have been found to be useful tools for evaluating bone status [20,21]. The relationship between gait parameters and bone status has been examined using ultrasound parameters, and gait speed has been shown to be significantly associated with better bone quality in a cross-sectional study [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Association between gait speed and bone strength in community-dwelling postmenopausal Japanese women

Sakazaki

Koike

Yanagimoto

et al. 2012

Environ Health Prev Med

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Objectives It is unclear whether gait speed can be used to predict bone status or to diagnose osteopenia or osteoporosis. The aim of our study was to determine whether the measurement of physical performance predicts bone strength in community-dwelling postmenopausal Japanese women. Methods We measured speed of sound (SOS), weight bearing index (WBI), maximum or usual gait speed, step length of each gait, single leg balance time with or without eyes closed, and grip strength among 1,061 postmenopausal women (mean age ± standard deviation 68 ± 8 years). Results After adjustments for age and body mass index, SOS was associated with maximum or usual gait speed and with step length during maximum speed gait, but not with WBI, grip strength, single-leg balance time with or without eyes closed, or step-length time during usual gait speed. When subjects were divided into quartile groups based on WBI (a marker of lower extremity strength), significant associations between usual or maximum gait speed and SOS were found only in the lowest and second lowest groups (first and second quartiles). Finally, analysis of sensitivity and specificity at various cut-off points of maximum gait speed to predict decreased SOS showed relatively high specificity compared with the corresponding sensitivity among those with low gait speed. Conclusions Maximum gait speed together with WBI may be a useful and specific test to predict bone status in postmenopausal older women.

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Section: Discussionmentioning

confidence: 99%

Association between gait speed and bone strength in community-dwelling postmenopausal Japanese women

Sakazaki

Koike

Yanagimoto

et al. 2012

Environ Health Prev Med

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“…Age-related changes have also been reported for water-coupled devices such as the Lunar Achilles. 17,18 Moris et al 18 found an annual decrease of 1.9 m/s for SOS and 0.59 dB/MHz for BUA using the Lunar Achilles device. Comparable decreases have been reported for Japanese and Chinese populations.…”

Section: Reference Databasementioning

confidence: 98%

Evaluation of a gel‐coupled quantitative ultrasound device for bone status assessment.

Njeh

Chen

Fan

et al. 2001

J of Ultrasound Medicine

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Objective. To evaluate a new gel-coupled calcaneal quantitative ultrasound system, Osteospace (Medilink, Montpellier, France), which was designed to assess the status of bone in the calcaneus. Methods. The study group consisted of 215 healthy white women aged 20 to 85 years and 51 white women aged 60 to 86 years with osteoporotic fractures. Fifty-two healthy women aged 50 to 85 years were randomly selected from the healthy cohort as the control group. All the women had calcaneal quantitative ultrasonic measurements. The women with osteoporotic fractures and the control group also had proximal femur and lumbar anteroposterior spine bone mineral density measurements using dual X-ray absorptiometry. Bone mineral density was also measured in a subgroup of 54 women at the calcaneus. Results. There was a significant inverse correlation of broadband ultrasound attenuation and speed of sound with age (P < .001). Short-term measurement precision values expressed as coefficients of variation were 1.72% for broadband ultrasound attenuation and 0.64% for speed of sound, and standardized shortterm precision values were 6.09% for broadband ultrasound attenuation and 3.87% for speed of sound. The correlations between the quantitative ultrasonic parameters and calcaneal bone mineral density were 0.69 (P = .0001) for broadband ultrasound attenuation and 0.45 (P = .0008) for speed of sound. Both quantitative ultrasonic parameters and all bone mineral density measurements of the hip and spine differed significantly between the control and osteoporotic fracture groups (P < .01). Age-, weight-, and height-adjusted odds ratios per SD decrease were as follows: broadband ultrasound attenuation, 1.79; speed of sound, 1.83; spine bone mineral density, 2.34; femoral neck bone mineral density, 1.69; and total hip bone mineral density, 1.85. The areas under the receiver operating characteristic curve for quantitative ultrasound parameters and bone mineral density measurements were close, ranging from 0.75 to 0.80. Conclusions. This new quantitative ultrasound system can detect age-and menopause-related influences on skeletal status and can discriminate healthy women from those with osteoporotic fractures in a manner comparable with that of bone mineral density measurement by dual X-ray absorptiometry. Key words: fracture; osteoporosis; precision; quantitative ultrasound; speed of sound; broadband ultrasound attenuation. Bone and Mineral Research, September 30-October 4, 1999, St Louis, Missouri, and September 22-26, 2000, Toronto, Ontario, Canada. Address correspondence and reprint requests to Christopher F. Njeh, PhD, Osteoporosis and Arthritis Research Group, Department of Radiology, University of California San Francisco, 350 Parnassus Ave, Suite 607, San Francisco, CA 94143-1349. Abbreviations BMD, bone mineral density; BUA, broadband ultrasound attenuation; CV, coefficient of variation; DXA, dual X-ray absorptiometry; OR, odds ratio; QUS, quantitative ultrasound; ROI, region of interest; SOS, speed of sound

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“…However, there is little information about long term precision in vivo and only a few longitudinal studies on changes of QUS parameters over time have been published [48][49][50]. While precision expressed as percentage coefficient of variation (CV) looks excellent for velocity parameters [41, [46][47], this may be misleading because it does not take into account the range of values across subjects or if sensitivity to skeletal change [44][45][46]. In order to take into account these factors a standardised percentage coefficient of variation (SCV) should be defined.…”

Section: Conclusion Drawn From Current In Vivo Studies?mentioning

confidence: 99%