Quantitative Template for Subtyping Primary Progressive Aphasia

What do pauses in narrative production reveal about the nature of word retrieval deficits in PPA?

“…The PPA-S group (n=11) showed atrophy largely confined to the left temporal lobe, including the superior, middle and inferior temporal gyri and the fusiform gyrus. These atrophy patterns are consistent with previous reports (Mesulam et al, 2009b, 2012; Rogalski et al, 2011). …”

What do pauses in narrative production reveal about the nature of word retrieval deficits in PPA?

“…The PPA-S group (n=11) showed atrophy largely confined to the left temporal lobe, including the superior, middle and inferior temporal gyri and the fusiform gyrus. These atrophy patterns are consistent with previous reports (Mesulam et al, 2009b, 2012; Rogalski et al, 2011). …”

Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand

“…To our knowledge, frontal lobe involvement has been rarely described causing disorders in LPA patients. This finding, however, is quite consistent with some previous studies of cortical thickness in LPA patients reported the relative cortical thinning in the left frontal region [ 8 , 19 ]. Regarding the language function of this frontal region, there was a study correlated the cortical thickness to language processing denoted that MFG and speech fluency were related [ 11 ].…”

Longitudinal assessment of short‐term memory deterioration in a logopenic variant primary progressive aphasia with post‐mortem confirmed A lzheimer's D isease pathology

“…Such a profile has also been seen in the non-fluent variant (Tree et al, 2001) and thus we would argue that emerging acquired dyslexia in PPA-LV is more likely similar to that seen in this other variant. It is also noteworthy, that our testing of spelling yielded similar impairments to reading and is consistent with other reports of impaired spelling in PPA-LV (Mesulam et al, 2009). Over time, testing demonstrated a decline in function of the phonological shortterm memory system characterized by (1) a reduction in digit span (with a much smaller drop for spatial span), (2) poorer performance on both word and non-word repetition (although a lexical advantage remained throughout), (3) the emergence of an impairment at homophone judgment (but no such impact on auditory rhyme judgment), (4) a lack of recency effect on any auditory immediate serial recall testing and normal recency on visual immediate serial recall testing, (5) an effect of phonological similarity for auditory presentation with an emergence of no such effect for visual presentation, and (6) an effect of length on immediate serial recall at both early and later stage testing.…”

What do pauses in narrative production reveal about the nature of word retrieval deficits in PPA?

“…The PPA-S group (n=11) showed atrophy largely confined to the left temporal lobe, including the superior, middle and inferior temporal gyri and the fusiform gyrus. These atrophy patterns are consistent with previous reports (Mesulam et al, 2009b, 2012; Rogalski et al, 2011). …”

Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand

“…To our knowledge, frontal lobe involvement has been rarely described causing disorders in LPA patients. This finding, however, is quite consistent with some previous studies of cortical thickness in LPA patients reported the relative cortical thinning in the left frontal region [ 8 , 19 ]. Regarding the language function of this frontal region, there was a study correlated the cortical thickness to language processing denoted that MFG and speech fluency were related [ 11 ].…”

Longitudinal assessment of short‐term memory deterioration in a logopenic variant primary progressive aphasia with post‐mortem confirmed A lzheimer's D isease pathology

“…Such a profile has also been seen in the non-fluent variant (Tree et al, 2001) and thus we would argue that emerging acquired dyslexia in PPA-LV is more likely similar to that seen in this other variant. It is also noteworthy, that our testing of spelling yielded similar impairments to reading and is consistent with other reports of impaired spelling in PPA-LV (Mesulam et al, 2009). Over time, testing demonstrated a decline in function of the phonological shortterm memory system characterized by (1) a reduction in digit span (with a much smaller drop for spatial span), (2) poorer performance on both word and non-word repetition (although a lexical advantage remained throughout), (3) the emergence of an impairment at homophone judgment (but no such impact on auditory rhyme judgment), (4) a lack of recency effect on any auditory immediate serial recall testing and normal recency on visual immediate serial recall testing, (5) an effect of phonological similarity for auditory presentation with an emergence of no such effect for visual presentation, and (6) an effect of length on immediate serial recall at both early and later stage testing.…”

What do pauses in narrative production reveal about the nature of word retrieval deficits in PPA?

“…The PPA-S group (n=11) showed atrophy largely confined to the left temporal lobe, including the superior, middle and inferior temporal gyri and the fusiform gyrus. These atrophy patterns are consistent with previous reports (Mesulam et al, 2009b, 2012; Rogalski et al, 2011). …”

Pattern of cortical thinning in logopenic progressive aphasia patients in Thailand

“…To our knowledge, frontal lobe involvement has been rarely described causing disorders in LPA patients. This finding, however, is quite consistent with some previous studies of cortical thickness in LPA patients reported the relative cortical thinning in the left frontal region [ 8 , 19 ]. Regarding the language function of this frontal region, there was a study correlated the cortical thickness to language processing denoted that MFG and speech fluency were related [ 11 ].…”

Longitudinal assessment of short‐term memory deterioration in a logopenic variant primary progressive aphasia with post‐mortem confirmed A lzheimer's D isease pathology

“…Such a profile has also been seen in the non-fluent variant (Tree et al, 2001) and thus we would argue that emerging acquired dyslexia in PPA-LV is more likely similar to that seen in this other variant. It is also noteworthy, that our testing of spelling yielded similar impairments to reading and is consistent with other reports of impaired spelling in PPA-LV (Mesulam et al, 2009). Over time, testing demonstrated a decline in function of the phonological shortterm memory system characterized by (1) a reduction in digit span (with a much smaller drop for spatial span), (2) poorer performance on both word and non-word repetition (although a lexical advantage remained throughout), (3) the emergence of an impairment at homophone judgment (but no such impact on auditory rhyme judgment), (4) a lack of recency effect on any auditory immediate serial recall testing and normal recency on visual immediate serial recall testing, (5) an effect of phonological similarity for auditory presentation with an emergence of no such effect for visual presentation, and (6) an effect of length on immediate serial recall at both early and later stage testing.…”