Quantitative spectroscopic photoacoustic imaging: a review

Cox, Ben; Laufer, Jan; Arridge, Simon; Beard, Paul C.

doi:10.1117/1.jbo.17.6.061202

Cited by 616 publications

(645 citation statements)

References 121 publications

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“…Photoacoustic imaging (PAI) -which relies upon the photo-acoustic effect, whereby a material absorbing light emits acoustic waves 94 involves exciting tissue with nonionizing laser pulses. When absorbed by chromophores in the tissue, this excitation generates heat, expansion of material and subsequent emission of ultrasound that can be detected with an ultrasonic transducer 95,96 . Both endogenous chromophores, such as oxyhaemoglobin and deoxyhaemoglobin, and exogenous contrast agents can be used, enabling PAI to provide multifaceted data containing both structural and functional information.…”

Section: Microbiota Changesmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

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| Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques -which can provide minimally invasive or noninvasive alternatives to biopsy -could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care. Members of the board and experts met to discuss the horizon scan in London, UK, in November 2015 and San Francisco, USA, in February 2016. Literature searches were performed using Web of Science, as well as through the advice of the advisory board and experts. The results of the horizon scan are presented in this Consensus Statement, which entails a review of EED, a discussion of technologies deemed relevant to EED (based on literature searches and the opinions of the advisory board and experts), and a series of recommendations for the future application of the rele vant technologies to the study and diagnosis of EED. In the Recommendations section, each technology has been assessed according to its suitability for application to EED and this assessment includes an evaluation of the cost, invasiveness and appropriateness for developing countries of each device and/or technique. This assessment was performed in a qualitative manner based on currently available information (for example, the present cost and size of the devices) and the opinions of the authors as to feasible future develop ment. Technique suitability for use in developing countries was determined in a qualitative manner after consideration of the need for advanced infrastructure and high levels of training for either system use or data analysis. Probable deployment time scales have also been assigned to each technique based on the current states of development and the degree of valid ation work that will be required before application to EED. These timescales have been tentatively defined as short-term (suitable for deployment immediately or within ~1 year), mediumterm (suit able for deployment within ~1-3 years) and long-term (suitable for deployme...

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Section: Microbiota Changesmentioning

confidence: 99%

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson

Hughes

Anastasova

et al. 2017

Nat Rev Gastroenterol Hepatol

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“…When this coloring algorithm is applied to the acquired multispectral data, the skin surface appears in light blue and the fat layer in red. The muscle tissue is bluish-green and becomes more reddish at greater depth, an effect due to spectral coloring [22]. The lipoma appears yellow-whitish and can clearly be distinguished from the surrounding tissue based on its color.…”

Section: Multispectral Imaging Of Lipomasmentioning

confidence: 99%

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

et al. 2017

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A wide variety of subcutaneous soft-tissue masses may be seen in clinical practice. Clinical examination based on palpation alone is often insufficient to identify the nature and exact origin of the mass, in which case imaging is necessary. We used handheld multispectral optoacoustic imaging technology (MSOT) in a proof-of-principle study to image superficial fatty tumors and compare the images with diagnostic ultrasound. Fatty tumors were clearly visualized by MSOT and exhibited a spectral signature which differed from normal fatty tissue or muscle tissue. Our findings further indicated that MSOT offers highly complementary contrast to sonography. Based on the performance achieved, we foresee a promising role for MSOT in the diagnosis and evaluation of subcutaneous soft-tissue masses.Picture: Pseudo-color representation of a cross-sectional multi-spectral optoacoustic slice through a subcutaneous lipoma. Multi-spectral information is encoded in color. The lipoma can clearly be distinguished from the surrounding tissue based on its color. Scalebar 1 cm.

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“…In general, aggregation intensifies the second harmonic generation of HGNs in contact with one another, effectively combining their collective energy to generate new photons with twice the frequency and half the wavelength [292][293][294][295]. HGN aggregates are also known to exhibit both hybridized plasmon modes, which are the result of surface plasmon interactions with cavity plasmon modes, and collective charge transfer resonances [296][297][298].…”

Section: Plasmon Coupling In Aggregates For Sersmentioning

confidence: 99%

“…Photoacoustic imaging is a hybridized technique combining non-ionizing radiation and ultrasonic detection [292,[370][371][372]. The photoacoustic signal is considered inherently weak due to the low intrinsic absorption of oxyhemoglobin and deoxyhemoglobin in the NIR [177,[373][374][375].…”

Section: Imagingmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Quantitative spectroscopic photoacoustic imaging: a review

Cited by 616 publications

References 121 publications

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Imaging of fatty tumors: appearance of subcutaneous lipomas in optoacoustic images

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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