Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis

Ogura, Ichiro; Kobayashi, Eizaburo; Nakahara, Ken; Igarashi, Kensuke; Haga‐Tsujimura, Maiko; Toshima, Hiroo

doi:10.1007/s12149-019-01390-5

Cited by 39 publications

(41 citation statements)

References 26 publications

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“…Previous reports state that SUV peak is especially useful among these parameters; however, we found a similar tendency for all parameters, in this study. We consider the reason why we found no difference with each parameter is that the VOI size was unified to a 19.2-mm sphere in all cases, whereas many studies measured the VOI size over a wide range [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a standardized uptake value (SUV) has been applied to evaluate bone single-photon emission computed tomography (SPECT) [15][16][17][18]. However, to the best of our knowledge, no published report has discussed SUV measurement in nonunion imaging using SPECT scans with 99m Tc hydroxymethylene diphosphonate ( 99m Tc-HMDP) or 99m Tc methylene diphosphonate ( 99m Tc-MDP).…”

Section: Introductionmentioning

confidence: 99%

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Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Zeng

Fukui

et al. 2021

J Orthop Surg Res

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Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. Methods We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. Results The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). Conclusions SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Zeng

Fukui

et al. 2021

J Orthop Surg Res

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show abstract

“…Previous reports state that SUV peak is especially useful among these parameters; however, we found a similar tendency for all parameters, in this study. We consider the reason why we found no difference with each parameter is that the VOI size was uni ed to a 19.2-mm sphere in all cases, whereas many studies measured the VOI size over a wide range [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a standardized uptake value (SUV) has been applied to evaluating bone single-photon emission computed tomography (SPECT) [15][16][17][18]. However, to the best of our knowledge, no published report has discussed SUV measurement in nonunion imaging using SPECT scans with 99m Tc hydroxymethylene diphosphonate ( 99m Tc-HMDP) or 99m Tc methylene diphosphonate ( 99m Tc-MDP).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion

Zeng

Fukui

et al. 2020

Preprint

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BackgroundRecently, a standardized uptake value (SUV) has been used to evaluate bone single photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters.MethodsWe evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. ResultsThe values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23). ConclusionsSUVmax, peak, mean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

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“…Recently, standardized uptake value (SUV) has been applied for the evaluation of bone single‐photon emission computed tomography‐computed tomography (SPECT‐CT) 8–12 . Furthermore, maximum SUV using Q. Metrix 13 and GI‐BONE 14 software could be useful for the evaluation of jaw lesions. However, to the best of our knowledge, few reports have been published on bone SPECT‐CT peak SUV of jaw lesions, especially comparison among chronic osteomyelitis, osteoradionecrosis and MRONJ.…”

Section: Introductionmentioning

confidence: 99%

Bone single‐photon emission computed tomography‐CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication‐related osteonecrosis of the jaw

Minami

Ogura

2020

J Med Imag Rad Onc

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Introduction Recently, standardized uptake value (SUV) has been applied for the evaluation of SPECT‐CT. This study was performed to investigate the bone SPECT‐CT peak SUV for chronic osteomyelitis, osteoradionecrosis and medication‐related osteonecrosis of the jaw (MRONJ). Methods Sixty‐five patients with jaw lesions (12 chronic osteomyelitis, 12 osteoradionecrosis and 41 MRONJ) underwent SPECT‐CT after injection of technetium‐99m hydroxymethylene diphosphonate. The peak SUV was compared for the chronic osteomyelitis with osteoradionecrosis and MRONJ using GI‐BONE software. Statistical analyses for the peak SUV were performed by one‐way repeated measures analysis of variance with Tukey's HSD test. A P‐value lower than 0.05 was considered as statistically significant. Results Peak SUV for chronic osteomyelitis (15.6 ± 4.4) was significantly higher than those for osteoradionecrosis (6.7 ± 2.1, P = 0.000) and MRONJ (10.7 ± 6.1, P = 0.019). Conclusion The SPECT‐CT peak SUV using GI‐BONE software can be useful for the evaluation of jaw lesions, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.

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Quantitative SPECT/CT imaging for medication-related osteonecrosis of the jaw: a preliminary study using volume-based parameters, comparison with chronic osteomyelitis

Cited by 39 publications

References 26 publications

Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion

Bone single‐photon emission computed tomography‐CT peak standardized uptake value for chronic osteomyelitis, osteoradionecrosis and medication‐related osteonecrosis of the jaw

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