Quantitative Relationships of the Interaction Between Sound and Kanamycin

Re, Brummett; Ke, Fox; Jb, Kempton

doi:10.1001/archotol.1992.01880050044011

Cited by 15 publications

(10 citation statements)

References 22 publications

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“…This treatment was designed to extend the hair cell damage as far as possible into the apical (low-frequency) region. Previous studies have shown that treatment with a combination of ototoxic drugs and intense sound exposure causes larger hair cell lesions than either drugs or sound presentation alone (Bone and Ryan, 1978;Collins, 1988;Brummett et al, 1990Brummett et al, , 1992Pye and Collins, 1991). Treatment with only low-frequency sound exposure does not result in hair cell damage localized to the apical end of the basilar papilla Rubel, 1982, 1985;Cotanche et al, 1994;Woolley, unpublished observations).…”

Section: Methodsmentioning

confidence: 92%

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

Woolley

Rubel

1999

J. Neurosci.

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Male Bengalese finches do not normally change their vocal patterns in adulthood; song is stereotyped and stable over time. Adult song maintenance requires auditory feedback. If adults are deafened, song will degrade within 1 week. We tested whether feedback of all sound frequencies is required for song maintenance. The avian basilar papilla is tonotopically organized; hair cells in the basal region encode high frequencies, and low frequencies are encoded in progressively apical regions. We restricted the spectral range of feedback available to a bird by killing either auditory hair cells encoding higher frequencies or those encoding both high and low frequencies and documented resultant changes in song. Birds were treated with either Amikacin alone to kill high-frequency hair cells or Amikacin and sound exposure to target hair cells across the entire papilla. During treatment, song was recorded from all birds weekly. After treatment and song recording, evokedpotential audiograms were evaluated on each bird, and papillas were evaluated by scanning electron microscopy. Results showed that hair cell damage over 46-63% of the basal papilla and the corresponding high-frequency hearing loss had no effect on song structure. In birds with hair cell damage extending further into the apical region of the papilla and corresponding low-frequency and high-frequency hearing loss, song degradation occurred within 1 week of beginning treatment and was comparable with degradation after surgical deafening. We conclude that either low-frequency spectral cues or temporal cues via feedback of the song amplitude envelope are sufficient for song maintenance in adult Bengalese finches.

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Section: Methodsmentioning

confidence: 92%

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

Woolley

Rubel

1999

J. Neurosci.

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“…We know of no other study demonstrating a protective effect of kanamycin or any other ototoxin against NIPTS. Instead, many studies have shown exacerbation of NIPTS by aminoglycosides in animals (e.g., Bombard et al 2005;Dayal et al 1971;Dayal and Barek 1975;Marques et al 1975;Hawkins et al 1975;Ryan and Bone 1978;Brown et al 1980;Brummett et al 1992). This effect has, therefore, been predicted for humans and anticipated to be enhanced in human infants (see Li and Steyger 2009).…”

Section: Kanamycin In the Early Vulnerability Windowmentioning

confidence: 99%

“…Thus, no special susceptibility of any single structure or cell type can provide a complete explanation. Animal studies also support synergistic interaction between noise and ototoxins, at least in adults (e.g., Dayal et al 1971;Dayal and Barek 1975;Marques et al 1975;Hawkins et al 1975;Ryan and Bone 1978;Brown et al 1980;Brummett et al 1992). Most of these applied high levels of noise and ototoxins.…”

Section: Introductionmentioning

confidence: 96%

“…Most of these applied high levels of noise and ototoxins. However, Brummett et al (1992) identified a synergistic effect between subclinical doses of white noise (as low as 75 dBA) and kanamycin (300 mg/kg) on hair cell loss in adult guinea pigs. It has remained unclear to date whether such synergy extends to neonates or is perhaps even more pronounced in neonates (Humes 1984;Henley and Rybak 1995;Li and Steyger 2009).…”

Section: Introductionmentioning

confidence: 97%

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Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Fernandez

Ohlemiller

Gagnon

et al. 2010

JARO

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Animal studies indicate that a combination of kanamycin (KM) and noise produces a synergistic effect, whereby the threshold shift from the combination is greater than the sum of the shifts caused by either agent alone. Most such studies have focused on adult animals, and it has remained unclear whether younger, presumably more susceptible, animals show an even greater synergistic effect. The present study tested the hypothesis that young CBA/J mice receiving a low dose of KM (300 mg/kg, 2×/day, s.c.) from 20 to 30 days post-gestational age followed by brief noise exposure (110 dB SPL; 4-45 kHz, 30 s) would show greater noise-induced permanent threshold shifts (NIPTS) than mice receiving either treatment alone. Noise exposure produced 30-40 dB of NIPTS and moderate hair cell loss in young saline-treated mice. KM alone at this dose had no effect on thresholds. Surprisingly, mice receiving KM plus noise were protected from NIPTS, showing ABR thresholds not significantly different from unexposed controls. Mice receiving KM prior to noise exposure also showed significantly less outer hair cell loss than saline-treated mice. Additional experiments indicated protection by KM when the noise was applied either 24 or 48 h after the last KM injection. Our results demonstrate a powerful protective effect of subchronic low-dose kanamycin against NIPTS in young CBA/J mice. Repeated kanamycin exposure may establish a preconditioned protective state, the molecular bases of which remain to be determined.

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“…Second, loop diuretic administration is frequently required in association with aminoglycosides in these patients, and these two classes of drugs show synergistic effects with regard to ototoxicity.6 Also, loud ambient noise has been found to increase the risk of ototoxicity. 8 Other accompanying risk factors are high serum bilirubin, prolonged mechanical ventilation, and low birth weight. 9 At present in the NICU, attention is focused on diagnosing the hearing loss, while monitoring of ototoxic effects is largely ignored.…”

mentioning

confidence: 99%

Global Problem of Drug‐Induced Hearing Loss

Arslan

Orzan

Santarelli

1999

Annals of the New York Academy of Sciences

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Clinically used drugs and chemical agents may potentially cause adverse effects to the human auditory and vestibular systems. Many of them, such as aminoglycosides and cisplatin, can play a critical role in the treatment of serious or life-threatening diseases; others, like loop diuretics or salycilates, offer such important therapeutical effects compared to the ototoxic side effects that the ototoxicity risk can be considered to be of minor importance. The problem of ototoxic side effects is more acute in developing countries, where highly effective and low-cost drugs are more easily prescribed without adequate monitoring. Medical awareness of doses, forms of administration, populations at risk, and possible synergism is necessary in order to develop appropriate care in the prescription of drugs with ototoxic side effects. Relatively recent issues such as risk-benefit analysis, patient-informed consent, and quality-of-life considerations, particularly when life expectancy can be low, are also to be considered. At present, a uniform method of monitoring for all potentially ototoxic therapeutics does not seem reasonable or practical. It is recommended, however, that individual auditory function be noted for a particular drug being employed. Protocols and exams should be easy, quick, sensitive, reliable, and as objective as possible. Benefits of audiological monitoring include the opportunity to change the patient's treatment course, improvement of patient and family awareness of the impact of hearing impairment, and timely prescription of amplification devices. Finally, particular attention should be paid to high-risk populations such as neonatal intensive care unit patients.

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Quantitative Relationships of the Interaction Between Sound and Kanamycin

Cited by 15 publications

References 22 publications

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

High-Frequency Auditory Feedback Is Not Required for Adult Song Maintenance in Bengalese Finches

Protection against Noise-Induced Hearing Loss in Young CBA/J Mice by Low-Dose Kanamycin

Global Problem of Drug‐Induced Hearing Loss

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