2021
DOI: 10.3390/cells10082021
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Abstract: Aging is associated with a general decline in cognitive functions, which appears to be due to alterations in the amounts of proteins involved in the regulation of synaptic plasticity. Here, we present a quantitative analysis of proteins involved in neurotransmission in three brain regions, namely, the hippocampus, the cerebral cortex and the cerebellum, in mice aged 1 and 22 months, using the total protein approach technique. We demonstrate that although the titer of some proteins involved in neurotransmission… Show more

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Cited by 8 publications
(4 citation statements)
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“…The observed significant alterations of dendritic spines prompted us to test whether the prolonged Pyg inhibition was reflected by changes in levels of hippocampal proteins. Our previous studies showed that aging correlated with global alterations in the hippocampal proteome (Drulis‐Fajdasz et al, 2021; Gostomska‐Pampuch et al, 2021). Here, we demonstrated that the 2‐week treatment with BAY changed concentrations of hundreds of hippocampal proteins (Figure 5b–d).…”
Section: Discussionmentioning
confidence: 96%
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“…The observed significant alterations of dendritic spines prompted us to test whether the prolonged Pyg inhibition was reflected by changes in levels of hippocampal proteins. Our previous studies showed that aging correlated with global alterations in the hippocampal proteome (Drulis‐Fajdasz et al, 2021; Gostomska‐Pampuch et al, 2021). Here, we demonstrated that the 2‐week treatment with BAY changed concentrations of hundreds of hippocampal proteins (Figure 5b–d).…”
Section: Discussionmentioning
confidence: 96%
“…The sample preparation and proteomic measurements were performed as described before (Drulis‐Fajdasz et al, 2021) using two groups of female C57BL/10 J mice: young (8‐week‐old; n = 10) and old (20‐ to 22‐month‐old; n = 10), which were treated with BAY ( n = 5/group) or saline ( n = 5/group), as described in Methods 5.2. The overview of the proteomic experiment is presented in Figure 5a.…”
Section: Methodsmentioning
confidence: 99%
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