2013
DOI: 10.1002/pmic.201200463
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Abstract: Chronic low-dose ionizing radiation induces cardiovascular disease in human populations but the mechanism is largely unknown. We suggested that chronic radiation exposure may induce endothelial cell senescence that is associated with vascular damage in vivo. We investigated whether chronic radiation exposure is causing a change in the onset of senescence in endothelial cells in vitro. Indeed, when exposed to continuous low-dose rate gamma radiation (4.1 mGy/h), primary human umbilical vein endothelial cells (H… Show more

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Cited by 99 publications
(101 citation statements)
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References 65 publications
(66 reference statements)
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“…Interestingly, recent work has shown that microRNAs can modulate the regulation of radiation-induced DNA damage and premature senescence [63]. Consistent with this hypothesis is the recent finding showing that chronic radiation-induced DNA damage and oxidative stress result in induction of p53/p21 pathway that inhibits the replicative potential of primary human umbilical vein endothelial cells and leads to premature senescence [64].…”
Section: Biological Mechanismsmentioning
confidence: 89%
“…Interestingly, recent work has shown that microRNAs can modulate the regulation of radiation-induced DNA damage and premature senescence [63]. Consistent with this hypothesis is the recent finding showing that chronic radiation-induced DNA damage and oxidative stress result in induction of p53/p21 pathway that inhibits the replicative potential of primary human umbilical vein endothelial cells and leads to premature senescence [64].…”
Section: Biological Mechanismsmentioning
confidence: 89%
“…Proteins with ratios of H/L or M/L label greater than 1.3-fold or less than −1.3-fold (One sample t-test; p ≤ 0.05; Perseus statistical tool) were defined as significantly differentially expressed. The use of this fold change cut off is based on previously published data [22,24,25].…”
Section: Quantification Of Labeled Proteinsmentioning
confidence: 99%
“…Data processing for protein identification and quantification of ICPL pairs was performed using Proteome Discoverer version 1.3 (Thermo Fisher) as described before [21,22]. Briefly, Proteome Discoverer software performs automated statistical analysis of the results and uses unique peptides to calculate accurate relative protein quantification.…”
Section: Quantification Of Labeled Proteinsmentioning
confidence: 99%
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“…However, specific radiation exposure-related molecular events have yet to be identified. Hence, identifying proteins potentially involved in adaptive responses to radiation would greatly enhance our understanding of the molecular mechanisms associated with protection against low-dose radiation, which could diminish the harmful effects of successive exposures to high-dose radiation (Yentrapalli et al 2013).…”
Section: Introductionmentioning
confidence: 99%