Quantitative myocardial perfusion PET combined with coronary anatomy derived from CT angiography: Validation of a new fusion and visualisation software

Clinical Value of Absolute Quantification of Myocardial Perfusion With 15 O-Water in Coronary Artery Disease

“…The lines are estimates of the tracer uptake characteristics. In all tracers except 15 O-water, tracer extraction is reduced when perfusion is increased. MIBI indicates sestamibi.…”

“…Normal MBF at rest is from 0.6 to 1 mL/g per minute and increases by 3-to 5-fold in stress as the coronary arteries dilate. 7 The tracers most widely used for the quantification of myocardial perfusion with PET are 15 O-water and 13 Nammonia. They provide absolute information of MBF over a wide range of blood flows, but their production requires a cyclotron.…”

“…10,11 More recently, because of the increased use of PET (and PET/CT) in clinical cardiology and the development of analysis methods, simple and robust perfusion quantification has become available. [12][13][14][15] However, large patient studies demonstrating the value of absolute quantification in the detection of CAD, as well as in the guidance of the therapy, are still lacking. In a recent study by Hajjiri et al, 16 27 patients with known or suspected CAD were studied.…”

“…Before invasive coronary angiography, coronary CT angiography followed by PET perfusion imaging during adenosine stress were performed in 104 of these patients using 15 O-water and dynamic nongated imaging (GE Discovery VCT PET/CT; GE Healthcare; Waukesha, WI). In 3 subjects, a PET study was not possible because of technical reasons.…”

“…Rest-stress perfusion cardiac PET was performed with 900 to 1100 MBq of 15 O-labeled water (Radiowater Generator; Hidex Oy; Turku, Finland) at rest as an intravenous bolus over 15 s at an infusion rate of 10 mL/min. A dynamic, nongated acquisition of the heart over 4 minutes 40 s was performed (14ϫ5 s, 3ϫ10 s, 3ϫ20 s, and 4ϫ30 s).…”