Abstract:PurposeAlthough safe at therapeutic levels, excess intake of acetaminophen can lead
to hepatic injury or acute liver failure (ALF). A number of different factors
influence metabolism and hepatotoxicity of acetaminophen in patients. Three of the
most important are a patient’s physiological response to fasting, alcohol
consumption, and chronic acetaminophen consumption. The molecular and enzymatic
underpinnings for these processes have been extensively studied. The purpose of
this study is to examine and quantif…
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