Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.01.020 View full text
Simone Schiesel, Michael Lämmerhofer, Alexander Leitner, Wolfgang Lindner

Abstract: Potential impurities in a parenteral infusion solution for amino acid supplementation containing alanylglutamine (AlaGln) and glycyltyrosine (GlyTyr) as peptide constituents have been determined. Such complex multicomponent pharmaceutical formulations with reactive ingredients may yield a multitude of impurities in stress testing samples. Thus, three stability indicating LC-ESI-MS/MS methods were developed for the establishment of quantitative impurity profiles employing a Chiralpak QN-AX and a Polysulfoethyl …

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