Quantitative grating-based x-ray dark-field computed tomography

Wang, Zhentian; Kang, K.; Huang, Zhifeng; Chen, Zhiqiang

doi:10.1063/1.3213557

Cited by 121 publications

(92 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In classical radiography, the minus logarithm of the absorption signal T is well known as the line integral of the attenuation coefficients, and the minus logarithm of the scattering signal S is directly proportional to the linear integration of the generalized scattering parameters 24 :…”

Section: Resultsmentioning

confidence: 99%

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

et al. 2014

View full text Add to dashboard Cite

Microcalcifications can be indicative in the diagnosis of early breast cancer. Here we report a non-invasive diagnostic method that may potentially distinguish between different types of microcalcifications using X-ray phase-contrast imaging. Our approach exploits the complementary nature of the absorption and small-angle scattering signals of microcalcifications, obtained simultaneously with an X-ray grating interferometer on a conventional X-ray tube. We demonstrate that the new approach has 100% sensitivity and specificity when applied to phantom data, and we provide evidence of the solidity of the technique by showing its discrimination power when applied to fixed biopsies, to non-fixed tissue specimens and to fresh, whole-breast samples. The proposed method might be further developed to improve early breast cancer diagnosis and has the potential to increase the diagnostic accuracy and reduce the number of uncomfortable breast biopsies, or, in case of widespread microcalcifications, to select the biopsy site before intervention.

show abstract

Section: Resultsmentioning

confidence: 99%

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Therefore, both refractive index decrement d and linear scattering coefficient e can be quantitatively reconstructed simultaneously. 14,29,30 It should be noted that the above deduction is valid for both 1D and 2D speckle scanning approach. Since it is too time consuming to perform 2D raster scan, we only validated the proposed method using 1D scanning data for tomography.…”

Section: -mentioning

confidence: 99%

“…To avoid this, the Hilbert filter algorithm was used to reconstruct the refractive index decrement using the horizontal differential phase images. 9 The dark-field image corresponds to the line integral of scattering power, 30 and the Ram-Lak filter was used for dark-field reconstruction. 15 Fig .…”

Section: -3mentioning

confidence: 99%

“…X-ray dark-field imaging, based on smallangle scattering of X-rays, reflects broadening of the ray and can be quantitatively evaluated in terms of second moment of scattering angle distribution. 14,29,30 In this paper, we show how the second moment of scattering angle distribution can be related to the cross-correlation degradation of speckle and present quantitative 3D tomographic reconstruction of darkfield and phase signals. Importantly, the spatial resolution for X-ray dark-field and phase CT has improved from previous tens of pixels down to a single pixel size.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Quantitative X-ray dark-field and phase tomography using single directional speckle scanning technique

Wang

Kashyap

Sawhney

2016

Applied Physics Letters

View full text Add to dashboard Cite

X-ray dark-field contrast tomography can provide important supplementary information inside a sample to the conventional absorption tomography. Recently, the X-ray speckle based technique has been proposed to provide qualitative two-dimensional dark-field imaging with a simple experimental arrangement. In this letter, we deduce a relationship between the second moment of scattering angle distribution and cross-correlation degradation of speckle and establish a quantitative basis of X-ray dark-field tomography using single directional speckle scanning technique. In addition, the phase contrast images can be simultaneously retrieved permitting tomographic reconstruction, which yields enhanced contrast in weakly absorbing materials. Such complementary tomography technique can allow systematic investigation of complex samples containing both soft and hard materials.

show abstract

“…Through the combination of wave optics and MC, absorption, phase-shift, interference and scattering can be modelled within one framework. Recently a number of publications have been made that investigate the dark-field contrast formation mechanism Yashiro et al, 2010;Wang et al, 2009b;Jensen et al, 2010;Lynch et al, 2011;Chen et al, 2010) and different efforts to investigate GI using MC have already been published (Cong et al, 2012;Bartl et al, 2010), but, so far in the investigation of X-ray scattering, the particle and wave approach have been considered separately. However, our approach should provide new insights into the matter, since it combines MC with wave optics within the same framework.…”

Section: Introductionmentioning

confidence: 99%

Combining Monte Carlo methods with coherent wave optics for the simulation of phase-sensitive X-ray imaging

et al. 2014

View full text Add to dashboard Cite

Phase-sensitive X-ray imaging shows a high sensitivity towards electron density variations, making it well suited for imaging of soft tissue matter. However, there are still open questions about the details of the image formation process. Here, a framework for numerical simulations of phase-sensitive X-ray imaging is presented, which takes both particle-and wave-like properties of X-rays into consideration. A split approach is presented where we combine a Monte Carlo method (MC) based sample part with a wave optics simulation based propagation part, leading to a framework that takes both particle-and wavelike properties into account. The framework can be adapted to different phasesensitive imaging methods and has been validated through comparisons with experiments for grating interferometry and propagation-based imaging. The validation of the framework shows that the combination of wave optics and MC has been successfully implemented and yields good agreement between measurements and simulations. This demonstrates that the physical processes relevant for developing a deeper understanding of scattering in the context of phase-sensitive imaging are modelled in a sufficiently accurate manner. The framework can be used for the simulation of phase-sensitive X-ray imaging, for instance for the simulation of grating interferometry or propagation-based imaging.

show abstract

Quantitative grating-based x-ray dark-field computed tomography

Cited by 121 publications

References 13 publications

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

Non-invasive classification of microcalcifications with phase-contrast X-ray mammography

Quantitative X-ray dark-field and phase tomography using single directional speckle scanning technique

Combining Monte Carlo methods with coherent wave optics for the simulation of phase-sensitive X-ray imaging

Contact Info

Product

Resources

About