Quantitative extraction using flowing nano-liter droplet in microfluidic system

Kumemura, Momoko; Korenaga, Takashi

doi:10.1016/j.aca.2005.10.086

Cited by 58 publications

(43 citation statements)

References 29 publications

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“…These methods enable formation of dispersions with highly attractive features, particularly the control over the size and narrow distribution of the sizes of individual droplets. With the rapid development of droplet formation techniques in microfluidic devices, several applications for the microfluidic chemical processing based on droplets have been demonstrated, including production of monodispersed microparticles (Nisisako et al 2004;Xu et al 2005;Utada et al 2005;Gong et al 2007), enhancement of mixing Cygan et al 2005), crystallization of proteins (Zheng et al 2004), synthesis of nanoparticles (Takagi et al 2004;Yanagishita et al 2004), and microchemical analysis (Kumemura and Korenaga 2006;Sun et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Correlations of droplet formation in T-junction microfluidic devices: from squeezing to dripping

Tan

et al. 2008

Microfluid Nanofluid

411

252

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In this work, we have systematically analyzed the scaling law of droplet formation by cross-flow shear method in T-junction microfluidic devices. The droplet formation mechanisms can be distinguished by the capillary number for the continuous phase (Ca c ), which are the squeezing regime (Ca c \ 0.002), dripping regime (0.01 \ Ca c \ 0.3), and the transient regime (0.002 \ Ca c \ 0.01). Three corresponding correlations have been suggested in the different range of Ca c . In the dripping regime, we developed a modified capillary number for the continuous phase (Ca c 0 ) by considering the influence of growing droplet size on the continuous phase flow rate. And the modified model could predict droplet diameter more accurately. In the squeezing regime, the final plug length was contributed by the growth and 'squeeze' stages based on the observation of dynamic break-up process. In the transient regime, we firstly suggested a mathematical model by considering the influences of the above two mechanisms. The correlations should be very useful for the application of controlling droplet size in T-junction microfluidic devices.

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Section: Introductionmentioning

confidence: 99%

Correlations of droplet formation in T-junction microfluidic devices: from squeezing to dripping

Tan

et al. 2008

Microfluid Nanofluid

411

252

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“…[60] Die Idee war wieder, die Fläche der Grenzschicht zu vergrößern, die unabhängig von der Geometrie des Kanals ist, aber leicht durch die Größe der Tropfen gesteuert werden kann. Eine Extraktion eines Al-DHABKomplexes aus Wasser in TBP (Tributylphosphat) gelang mithilfe eines T-förmigen Mikrokanals, wobei der Al-DHAB- sobald spektroskopische Methoden, die eine lokale Charakterisierung der Spezies im Kanal ermöglichen, verfügbar sind.…”

Section: Mikrofluidik Für Die Flüssig-flüssig-extraktion Anorganischeunclassified

Mikrofluidik in der anorganischen Chemie

2010

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In den letzten Jahren hat die Mikrofluidik in der Chemie stark an Bedeutung gewonnen. Miniaturisierte chemische Vorrichtungen ermöglichen einen kontrollierten Flüssigkeitstransport und schnelle chemische Reaktionen und sind darüber hinaus Kosten sparend, wenn man sie mit konventionellen Reaktoren vergleicht. Sowohl in der (Bio‐)Analytik als auch in der organischen Synthese werden diese Vorteile bereits ausgiebig genutzt, weniger hingegen in der anorganische Chemie und den Materialwissenschaften. Dennoch wird diese Thematik auch in der Anorganik bei der Entwicklung von Mikroreaktoren für die Trennung und selektive Extraktion von Metallionen gestreift. Bei Funktionsmaterialien wird die Mikrofluidik hauptsächlich für Verbesserungen in der Synthese von Nanopartikeln (besonders von Metall‐, Metalloxid‐ und Halbleiternanopartikeln) eingesetzt. Mikrofluidiktechniken können auch für die Entwicklung von komplizierteren anorganischen (Hybrid‐)Materialien genutzt werden.

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“…Microfluidic devices have proven useful for observing mass transfer quantitatively on a single drop basis. [14][15][16][17] Microfluidic devices are ideal model environments since they can produce high mixing speeds with known interfacial areas.…”

Section: Introductionmentioning

confidence: 99%

Drop mass transfer in a microfluidic chip compared to a centrifugal contactor

et al. 2014

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A model system was developed for enabling a multiscale understanding of centrifugal-contactor liquid-liquid extraction. The system consisted of Nd(III) 1 xylenol orange in the aqueous phase buffered to pH 5 5.5 by KHP, and dodecane 1 thenoyltrifluroroacetone (HTTA) 1 tributyphosphate (TBP) in the organic phase. Diffusion constants were measured for neodymium in both the organic and aqueous phases, and the Nd(III) partition coefficients were measured at various HTTA and TBP concentrations. A microfluidic channel was used as a high-shear model environment to observe mass transfer on a droplet scale with xylenol orange as the aqueous-phase metal indicator; mass-transfer rates were measured quantitatively in both diffusion and reaction limited regimes on the droplet scale. The microfluidic results were comparable to observations made for the same system in a laboratory scale liquid-liquid centrifugal contactor, indicating that single drop microfluidic experiments can provide information on mass transfer in complicated flows and geometries.

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Quantitative extraction using flowing nano-liter droplet in microfluidic system

Cited by 58 publications

References 29 publications

Correlations of droplet formation in T-junction microfluidic devices: from squeezing to dripping

Correlations of droplet formation in T-junction microfluidic devices: from squeezing to dripping

Mikrofluidik in der anorganischen Chemie

Drop mass transfer in a microfluidic chip compared to a centrifugal contactor

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