“…Different analytical techniques have been documented for the quantitative determination of VLP in the literature like: voltammetric methods, 36,37 spectrophotometric methods, [38][39][40][41][42][43][44][45] spectrofluorimetric methods, 46,47 capillary electrophoresis. 45 Moreover, different chromatographic methods were reported in literature like high performance thin layer chromatography (HPTLC), 48,49 high performance liquid z E-mail: amr.bekhet@pharma.cu.edu.eg chromatography with UV detection (HPLC-UV), [50][51][52][53] HPLC with fluorescence detection, 54 HPLC-MS/MS, 55 ultra-performance liquid chromatography with ultraviolet detection (UPLC-UV), 44 UPLC with fluorescence detection, 56 UPLC with mass spectrometric detection (UPLC-MS/MS). 57 The primary aim of this research is to develop a feasible, rapid, and eco-friendly sensor for detecting VLP in spiked human plasma at its maximum plasma concentration (Cmax) in the presence of SOF, to be used in future TDM studies in clinical laboratories.…”