Quantitative Estimation of Keratin Production by the Epidermis

Goldschmidt, Herbert; Kligman, Albert M.

doi:10.1001/archderm.1963.01590240033007

Cited by 28 publications

(5 citation statements)

References 4 publications

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“…The protein content of normal scale has been reported by various authors: 65%, 27 50–60%, 28 and 70%. 29 In this study, the average protein content per gram of scale was 575 mg (57.5%). The protein content per gram of scale for ED secondary to psoriasis was significantly lower ( p < 0.05) than for ED secondary to eczema.…”

Section: Discussionmentioning

confidence: 72%

Quantitative estimation and recommendations for supplementation of protein lost through scaling in exfoliative dermatitis

et al. 1999

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Section: Discussionmentioning

confidence: 72%

Quantitative estimation and recommendations for supplementation of protein lost through scaling in exfoliative dermatitis

et al. 1999

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“…Keratin is the chief and most important product of human skin (6). Normal keratinization has been extensively studied (7–11) but we could find no data on pathologic keratinization as systematically studied by polarizing microscopy.…”

mentioning

confidence: 83%

Keratin in Normal and Abnormal Epidermis

Castillo

Foraker

1966

J American Geriatrics Society

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“…Skin was heated to approximately 60ºC for 2 minutes and the epidermis was gently peeled off from the skin (Goldschmidt and Kligman, 1963). The fresh epidermis was placed onto filter paper, allowed to dry and stored at −20ºC until used.…”

Section: Porcine Epidermismentioning

confidence: 99%

Resealing of electroporation of porcine epidermis using phospholipids and poloxamers

Burgess

Zhao

Sen

et al. 2007

International Journal of Pharmaceutics

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The resealing of porcine epidermis after electroporation is investigated. Porcine epidermis was subjected to electroporation (30 pulses at 100 V, 1 msec and at 1 Hz) in a vertical diffusion apparatus, in the presence of 2 mg/ml dimyristoylphosphatiylserine, to produce a long lasting permeable state. Resealing treatments include incubation in 0.0625-0.25 mM poloxamer P188, or incorporation of phosphatidylcholines (PC) and/or cationic lipids with additional pulses. The recovery of electric resistance of the epidermis samples after electroporation with or without resealing treatments was monitored. The transports of carboxyfluorescein and glucose were measured during the recovery process. Both P188 and PC were effective in resealing in terms of electric conductance and transport, with P188 reacting more rapidly and completely. P188 mediated lipid exchange between stratum corneum lipid particles was measured by FRET. Lipid reorganization facilitated by P188 and PC is suggested to be a major resealing mechanism of electroporation damage.

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Quantitative Estimation of Keratin Production by the Epidermis

Cited by 28 publications

References 4 publications

Quantitative estimation and recommendations for supplementation of protein lost through scaling in exfoliative dermatitis

Quantitative estimation and recommendations for supplementation of protein lost through scaling in exfoliative dermatitis

Keratin in Normal and Abnormal Epidermis

Resealing of electroporation of porcine epidermis using phospholipids and poloxamers

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