Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Bergamasco, L.; Accatino, A.; Priano, Lorenzo; Neiger‐Aeschbacher, Gina; Cizinauskas, Sigitas; Jaggy, A.

doi:10.1016/s1090-0233(02)00254-x

Cited by 38 publications

(19 citation statements)

References 38 publications

(41 reference statements)

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“…EEG examinations were performed in a quiet, darkened room. Dogs were placed in sternal recumbency and electrodes were placed transcutaneously in a 14 channel montage, modified from a 17-channel montage as described previously [62]. To assure good electrical contact with the electrodes, the scalp was defatted by rubbing vigorously with ethyl alcohol.…”

Section: Methodsmentioning

confidence: 99%

Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs

et al. 2012

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Epilepsy is the most common neurological disorder in dogs, with an incidence ranging from 0.5% to up to 20% in particular breeds. Canine epilepsy can be etiologically defined as idiopathic or symptomatic. Epileptic seizures may be classified as focal with or without secondary generalization, or as primary generalized. Nine genes have been identified for symptomatic (storage diseases) and one for idiopathic epilepsy in different breeds. However, the genetic background of common canine epilepsies remains unknown. We have studied the clinical and genetic background of epilepsy in Belgian Shepherds. We collected 159 cases and 148 controls and confirmed the presence of epilepsy through epilepsy questionnaires and clinical examinations. The MRI was normal while interictal EEG revealed abnormalities and variable foci in the clinically examined affected dogs. A genome-wide association study using Affymetrix 50K SNP arrays in 40 cases and 44 controls mapped the epilepsy locus on CFA37, which was replicated in an independent cohort (81 cases and 88 controls; combined p = 9.70×10−10, OR = 3.3). Fine mapping study defined a ∼1 Mb region including 12 genes of which none are known epilepsy genes or encode ion channels. Exonic sequencing was performed for two candidate genes, KLF7 and ADAM23. No variation was found in KLF7 but a highly-associated non-synonymous variant, G1203A (R387H) was present in the ADAM23 gene (p = 3.7×10−8, OR = 3.9 for homozygosity). Homozygosity for a two-SNP haplotype within the ADAM23 gene conferred the highest risk for epilepsy (p = 6.28×10−11, OR = 7.4). ADAM23 interacts with known epilepsy proteins LGI1 and LGI2. However, our data suggests that the ADAM23 variant is a polymorphism and we have initiated a targeted re-sequencing study across the locus to identify the causative mutation. It would establish the affected breed as a novel therapeutic model, help to develop a DNA test for breeding purposes and introduce a novel candidate gene for human idiopathic epilepsies.

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Section: Methodsmentioning

confidence: 99%

Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs

et al. 2012

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“…Propofol was chosen in the current study because it has been used successfully for EEG recording in dogs (Accatino and others 1997, Bergamasco and others 2003). Dose-dependently, it may have proconclusive and anticonvulsive properties in human beings and animals although its mechanism of action has not been fully understood so far (Baraka and Aouad 1997, Bergamasco and others 2003, Löscher 2009).…”

Section: Methodsmentioning

confidence: 99%

Activation procedures in the electroencephalograms of healthy and epileptic cats under propofol anaesthesia

Brauer¹,

Kästner²,

Kulka³

et al. 2012

Veterinary Record

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The current study evaluated the diagnostic value of electroencephalographic recordings (EEG) in cats with epilepsy under special consideration of photic stimulation and hyperventilation. EEGs in six healthy cats were recorded under light (mean dose of 0.23 mg/kg/min) and deep (mean dose of 0.7 mg/kg/min) propofol anaesthesia, whereas EEGs in 13 diseased cats were recorded under a propofol anaesthesia which was kept as light as possible (mean dose of 0.39 mg/kg/min). Paroxysmal discharges were detected in six of 13 cats suffering from seizures (two cats with idiopathic epilepsy and four cats with symptomatic epilepsy). Activation techniques did not enhance the diagnostic value of the EEGs. Photic driving was detected in one of six healthy cats under light, in five of six healthy cats under deep propofol anaesthesia and in 11 of 13 cats with seizures. Systematic use of activation techniques does not seem to increase the diagnostic yield of the recorded EEGs and should not be used in a clinical setting until future studies indicate value. Further investigations into the origin of photic driving under propofol anaesthesia are needed and could lead to the development of a reliable animal model to research into drug effects on the EEG.

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“…Ground and reference electrodes were set below the both ear. A method of standardized placement of EEG electrodes similar to the 10-20 international system used for the human being was used [2]. The low-frequency filter was set at 2 Hz, and the high-frequency setting was 50 Hz.…”

mentioning

confidence: 99%

Electroencephalography (EEG) Spectral Edge Frequency for Assessing the Sedative Effect of Acupuncture in Dogs

Kim

Nam

2006

J. Vet. Med. Sci.

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ABSTRACT. Electroencephalography (EEG) is an effective method for the evaluation of sedation or anesthesia. The purpose of this study was to examine the sedative effect of acupuncture by electroencephalographic spectral edge frequency (SEF) in Miniature Schnauzer dogs (4.2-6.1 kg, 1-2 years old). The acupuncture points "GV20 and Yintang" were applied for 20 min. Sedation level was assessed before, during, and after acupuncture by spectral edge frequency 95 values and the Ramsay sedation score. The spectral edge frequency 95 values were significantly reduced during acupuncture on GV20 or Yintang point and returned to the baseline values after acupuncture releasing. The Ramsay sedation score (RSS) also showed the acceptable sedation level during acupuncture. It was concluded that an acupuncture application at GV20 or Yintang point used in the present study would be a valuable method to induce the sedation in dogs. KEY WORDS: acupuncture, canine, spectral edge frequency.

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Quantitative electroencephalographic findings in beagles anaesthetized with propofol

Cited by 38 publications

References 38 publications

Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs

Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs

Activation procedures in the electroencephalograms of healthy and epileptic cats under propofol anaesthesia

Electroencephalography (EEG) Spectral Edge Frequency for Assessing the Sedative Effect of Acupuncture in Dogs

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