Quantitative determination of sulphamethazine and carbadox in animal feeds by paired ion high-performance liquid chromatography

McGary, Eddie D.

doi:10.1039/an9861101341

Cited by 16 publications

(4 citation statements)

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“…Several methods have been reported for SMZ determination. These methods include colorimetry [9], immunoassay [1,[10][11][12][13], gas chromatography [14][15][16][17], high performance liquid chromatography [18][19][20][21][22], thin layer chromatography [23], liquid chromatography [25][26][27][28][29], microbiological diffusion assay [29], microtitre plate assay [30], indirect atomic absorption spectrometry [31], ratiometric fluorescence with carbon and quantum dots [32], voltammetry [33], potentiometric sensors [34], piezoelectric sensors [35] and transmittance near infrared spectrometry [36].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric detection of low-levels of sulfamethazine in milk and pharmaceutical formulations using novel plastic membrane sensors

Hassan

Kamel

Elbehery

2018

J. Electrochem. Sci. Eng.

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Novel potentiometric sensors for selective screening of sulfamethazine (SMZ) in pharmaceutical preparations and milk samples are reported. The sensor membranes were made from PVC matrix doped with magnesium(II)-, manganese(II)- and dichlorotin (IV)-phthalocyanines as ionophores and aliquat-336 and nitron/SMZ ion-pair complex as ion exchangers. These sensors revealed fast, stable and near-Nernstian anionic response for the singly charged sulfamethazine anion over the concentration range 10<sup>-2 </sup>- 10<sup>-5</sup> M. The sensors exhibited good selectivity towards SMZ over most known anions, excipients and diluents commonly added in drug preparations. Validation of the proposed methods was demonstrated via evaluating the detection limit, linear response range, accuracy, precision (within-day repeatability) and between-day-variability. The sensors are easily interfaced with a double channel flow injection system and used for continuous monitoring of SMZ in drug formulations, spiked milk samples and biological tissues. The method offers the advantages of design simplicity, results accuracy, and automation feasibility.

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Section: Introductionmentioning

confidence: 99%

Potentiometric detection of low-levels of sulfamethazine in milk and pharmaceutical formulations using novel plastic membrane sensors

Hassan

Kamel

Elbehery

2018

J. Electrochem. Sci. Eng.

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“…A variety of analytical methods have been developed for its determination. Nitrite titration (1), ultraviolet (UV) spectrophotometry (2,3), and high-performance liquid chromatography (4,5) are among those frequently used.…”

Section: Introductionmentioning

confidence: 99%

Flow Injection On-line Photochemical Reaction Coupled to Spectrofluorimetry for the Determination of Sulfamethazine Using Sodium Sulfite as Sensitizing Reagent

He¹,

Chen²,

Cao³

1999

Microchemical Journal

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“…Methods frequently used for the determination of SMZ in pharmaceutical preparations include mainly high-performance liquid chromatography (HPLC) ( , ). In addition, Mahedero and Aaron () have developed a method involving flow injection and photochemically induced fluorescence.…”

Section: Introductionmentioning

confidence: 99%

Determination of Sulfamethazine and Trimethoprim in Liquid Feed Premixes by HPLC and Diode Array Detection, with an Analysis of the Uncertainty of the Analytical Results

Cancho-Grande

Falcon

Comesana

et al. 2001

J. Agric. Food Chem.

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Sulfamethazine (SMZ) and trimethoprim (TMP) are antibacterials used in veterinary practice. This paper describes a method for their determination in veterinary liquid feed premixes that is based on liquid chromatography with diode array detection. Gradient elution with methanol and ammonium acetate achieved excellent separation of the two analytes within 15 min without any interference from the matrix. Absorbance of the column effluent was monitored at 264 nm for SMZ and at 230 nm for TMP. Detailed analyses of the uncertainties of determinations afford estimated expanded uncertainties of, respectively, 0.2 and 0.1 w/v % for typical SMZ and TMP concentrations of 10.7 and 2.1 w/v %, respectively. At the lower end of the calibrated range of the method, the dominant source of uncertainty is the preparation of standards and the construction of the calibration line.

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Quantitative determination of sulphamethazine and carbadox in animal feeds by paired ion high-performance liquid chromatography

Cited by 16 publications

References 0 publications

Potentiometric detection of low-levels of sulfamethazine in milk and pharmaceutical formulations using novel plastic membrane sensors

Potentiometric detection of low-levels of sulfamethazine in milk and pharmaceutical formulations using novel plastic membrane sensors

Flow Injection On-line Photochemical Reaction Coupled to Spectrofluorimetry for the Determination of Sulfamethazine Using Sodium Sulfite as Sensitizing Reagent

Determination of Sulfamethazine and Trimethoprim in Liquid Feed Premixes by HPLC and Diode Array Detection, with an Analysis of the Uncertainty of the Analytical Results

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