Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography

Su, Li; Ji, Yong‐Sok; Tong, Nianting; Sarraf, David; He, Xiangui; Sun, Xiaodong; Xu, Xun; Sadda, Srinivas R

doi:10.1007/s00417-020-04639-2

Cited by 73 publications

(78 citation statements)

References 40 publications

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“…The CC images were binarized using a modified version of the previously reported method. 17 – 19 Briefly, the images were duplicated to apply two binarization methods. One image was processed first by a Hessian filter, followed by global thresholding using Huang's fuzzy thresholding method.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

Taweebanjongsin

Gaw

et al. 2020

Trans. Vis. Sci. Tech.

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To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods: Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects underwent spectral-domain OCT with enhanced depth imaging mode and spectral-domain optical coherent tomography angiography (OCTA). Main outcomes were subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), and choriocapillaris flow deficits (CC FD). Results: Twenty-two eyes of 12 uncomplicated pregnant women and 23 eyes of 15 nonpregnant, female controls were included. The mean age was 32.27 ± 6.96 years for the pregnant group and 30.08 ± 5.49 years for control group (P > 0.05). Mean SFCT was 238.70 ± 82.96 μm in the pregnant group, and 277.40 ± 61.79 μm in the control group. CVI was 67.58% ± 2.45% in the pregnant group and 67.31% ± 2.62% in the control group. The CC FD% was 54.06 ± 3.95 in the pregnant group, and 55.02 ± 3.78 in the control group. There was no significant difference between the pregnant and control groups (P > 0.05) in SFCT, CVI or CC FD. Conclusions: Although extensive hemodynamic changes occurred with pregnancy, choroidal measurements by OCT and OCTA demonstrated no differences in uncomplicated third-trimester pregnant women compared with nonpregnant controls. Translational Relevance: The unaltered choroid in uncomplicated third-trimester pregnancy we described allows clinicians to determine whether abnormal choroidal measurements could be used as a biomarker for complications of pregnancy.

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Section: Methodsmentioning

confidence: 99%

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

Taweebanjongsin

Gaw

et al. 2020

Trans. Vis. Sci. Tech.

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“…Vessel length density (VLD) was defined as the vessel length per unit area and was computed after skeletonization of the image, as previously described. 14 – 16 …”

Section: Methodsmentioning

confidence: 99%

“…VD for SCP was computed in accordance with prior reports. 13,14 In brief, images were duplicated in order to apply two binarization methods. One image was processed first by a Hessian filter, followed by global thresholding using Huang's fuzzy thresholding method.…”

Section: Octa Analysismentioning

confidence: 99%

“…To calculate the VD for DCP, the manufacturer's projection removal software was first applied, and then to remove the impact of any residual projections, the superficial large retinal vessels were excluded from quantitative analysis, as previously described. 13,14 VD was then assessed on this final resultant image.…”

Section: Octa Analysismentioning

confidence: 99%

“…Vessel length density (VLD) was defined as the vessel length per unit area and was computed after skeletonization of the image, as previously described. [14][15][16] For CC analysis, CC flow deficits (FDs) were measured using the Phansalkar method (radius = 21.5 μm), as described previously. 17,18 Small flow deficits (diameter less than approximately 24 μm) were removed from the obtained map, as they are believed to be within the range of normal intercapillary spacing and within normal oxygen diffusion capability.…”

Section: Octa Analysismentioning

confidence: 99%

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Comparison and Repeatability of High Resolution and High Speed Scans from Spectralis Optical Coherence Tomography Angiography

Corvi

Corradetti

Parrulli

et al. 2020

Trans. Vis. Sci. Tech.

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The purpose of this study was to evaluate and compare the repeatability of optical coherence tomography angiography (OCTA) derived retinal vascular quantitative metrics using high resolution (HR) versus high speed (HS) acquisition modes. Methods: Macular 4.4 × 2.9-mm OCTA images from normal, healthy volunteers were captured using both HR (768 A-scans × 256 B-scans) and HS (384 A-scans × 256 B-scans) acquisition protocols. Vessel density and vessel length density of the superficial capillary plexus and deep capillary plexus, as well as choriocapillaris flow deficit were computed. In a subset of eyes, the OCTA scans were repeated twice 2 days later and the same metrics were recomputed to assess repeatability, using intraclass correlation coefficients and coefficient of variation (CV). Results: Comparison of measurements between HR and HS acquisitions in 41 healthy eyes showed statistically significant differences for all quantitative metrics (P < 0.01). However, no significant differences were observed among the three repeated scans (one on day 1 and two on day 3) obtained with each of the acquisition modes. The CVs ranged from 0.01 to 0.03 with the HR mode and 0.01 to 0.04 with the HS mode. The intraclass correlation coefficients (ICCs) among measurements were similar and high for both HR and HS modes, ranging from 0.844 to 0.949. Conclusions: HR and HS OCTA acquisition modes both yielded repeatable quantitative metrics for the retinal circulation and the choriocapillaris. However, despite a similar field, the HR and HS derived measurements differed significantly. Translational Relevance: To establish OCTA imaging in clinical and research practice, standardized and repeatability image analysis are necessary.

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The Choroid

Spaide

2021

Pathologic Myopia

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Quantitative assessment of the retinal microvasculature and choriocapillaris in myopic patients using swept-source optical coherence tomography angiography

Cited by 73 publications

References 40 publications

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

Evaluation of the Choroid in Women with Uncomplicated Pregnancy

Comparison and Repeatability of High Resolution and High Speed Scans from Spectralis Optical Coherence Tomography Angiography

The Choroid

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