Quantitative Assessment of Erector Spinae Muscles in Patients with Chronic Obstructive Pulmonary Disease. Novel Chest Computed Tomography–derived Index for Prognosis

Tanimura, Kazuya; Satô, Susumu; Fuseya, Yoshinori; Hasegawa, Kôichi; Uemasu, Kiyoshi; Oguma, Tsuyoshi; Hirai, Toyohiro; Mishima, Michiaki; Muro, Shigeo

doi:10.1513/annalsats.201507-446oc

Cited by 156 publications

(197 citation statements)

References 33 publications

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“…The presence of significant relationships between functional parameters and longitudinal PaO 2 trajectories in patients with COPD is one of the novel findings from the present study. Moreover, these results are consistent with our report showing that diffusing capacity is a significant prognostic factor in male patients with stable COPD, 20 and that emphysema severity, which is closely associated with diffusing capacity, is a significant prognostic factor identified in numerous cohort studies, including our previous study. 21 Our findings suggest that patients with a low K CO should be closely observed and undergo serial assessments of physiological parameters, including PaO 2 .…”

Section: Discussionsupporting

confidence: 93%

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6‐year follow‐up study

et al. 2018

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Section: Discussionsupporting

confidence: 93%

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6‐year follow‐up study

et al. 2018

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“…Additionally, most cystic fibrosis patients were not age‐matched with this older control group. Also, it is unknown whether severe lung disease alters the geometry of the thoracic cavity, which could lead to differences in thoracic muscle CSA attributable to variation in the distribution of the thoracic muscles rather than muscle atrophy . However, in a previous study, we observed that a single thoracic axial CT slice was closely associated with thoracic muscle volume obtained from several slices in lung transplant candidates .…”

Section: Discussionmentioning

confidence: 80%

“…Similarly, in lung transplant patients, muscle CSA from abdominal CT has been associated with post‐transplant outcomes such as intensive care unit (ICU) and hospital length of stay . In patients with chronic obstructive pulmonary disease (COPD), muscle CSA from chest CT has been associated with disease severity , exercise capacity , and mortality . We have recently shown that measures of thoracic muscle CSA from a single axial slice of the chest correlated well with accepted measures of muscle mass and were reproducible in lung transplant candidates .…”

Section: Introductionmentioning

confidence: 97%

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

et al. 2017

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Low muscle mass is common in lung transplant (LTx) candidates; however, the clinical implications have not been well described. The study aims were to compare skeletal muscle mass in LTx candidates with controls using thoracic muscle cross-sectional area (CSA) from computed tomography and assess the association with pre- and post-transplant clinical outcomes. This was a retrospective, single-center cohort study of 527 LTx candidates [median age: 55 IQR (42-62) years; 54% male]. Thoracic muscle CSA was compared to an age- and sex-matched control group. Associations between muscle CSA and pre-transplant six-minute walk distance (6MWD), health-related quality of life (HRQL), delisting/mortality, and post-transplant hospital outcomes and one-year mortality were evaluated using multivariable regression analysis. Muscle CSA for LTx candidates was about 10% lower than controls (n = 38). Muscle CSA was associated with pre-transplant 6MWD, but not HRQL, delisting or pre- or post-transplant mortality. Muscle CSA (per 10 cm difference) was associated with shorter hospital stay [0.7 median days 95% CI (0.2-1.3)], independent of 6MWD. In conclusion, thoracic muscle CSA is a simple, readily available estimate of skeletal muscle mass predictive of hospital length of stay, but further study is needed to evaluate the relative contribution of muscle mass versus functional deficits in LTx candidates.

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“…Sarcopenia is prevalent in COPD, and is an independent risk factor for comorbidities and poor prognosis . In addition, our recent cohort study showed that the cross‐sectional area of antigravity muscle on chest computed tomography would represent a good prognostic index for COPD and might be associated with the physical activity level …”

Section: Introductionmentioning

confidence: 92%

“…13,14 In addition, our recent cohort study showed that the cross-sectional area of antigravity muscle on chest computed tomography would represent a good prognostic index for COPD and might be associated with the physical activity level. 15 The linkage among reduced muscle mass, physical inactivity and pulmonary dysfunction represents an important key feature of aged COPD patients. In addition, because COPD is a debilitating disease, malnutrition is also important for COPD patients.…”

Section: Introductionmentioning

confidence: 99%

Interdependence of physical inactivity, loss of muscle mass and low dietary intake: Extrapulmonary manifestations in older chronic obstructive pulmonary disease patients

Yoshimura

Satô

Muro

et al. 2017

Geriatrics Gerontology Int

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Aim: Extrapulmonary manifestations, such as reductions in skeletal muscle and physical inactivity, are important clinical features of patients with chronic obstructive pulmonary disease (COPD), and might depend on the severity of COPD. As it is still unclear whether the relationship between muscle loss and physical inactivity is dominated by a disease-specific relationship or caused by patient factors, including physiological aging, we aimed to investigate the pulmonary or extrapulmonary factors associated with physical inactivity among older COPD patients.Methods: A total of 38 older male COPD patients (aged ≥65 years) were enrolled, and were evaluated cross-sectionally. Skeletal muscle mass was measured using bioelectrical impedance, and physical activity and energy intake were recorded for 2 weeks using a pedometer and diary.Results: Daily step counts were successfully evaluated in 28 participants (mean forced expiratory volume in 1 s [%predicted; %FEV 1 ]; 49.5%), and ranged widely. The mean step counts was 5166 steps/day, and found to have a significant relationship with dyspnea (r = À0.46), diffusing capacity (r = 0.47), %FEV1 (r = 0.44), skeletal muscle index (r = 0.59) and total dietary intake (r = 0.47), but not with age (P = 0.14). A stepwise multivariate analysis showed that the skeletal muscle index (β = 0.50) and total dietary intake (β = 0.35) were significant determinants of the daily step count (R 2 = 0.46, p < 0.01).Conclusions: Although various pulmonary factors are associated with daily physical activity, skeletal muscle mass and dietary intake are more closely correlated with physical activity in COPD patients. Because physical inactivity might be the strongest predictor of prognosis, the present results suggest that a comprehensive treatment strategy must be considered for older COPD patients to improve their extrapulmonary manifestations and pulmonary dysfunction.

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Quantitative Assessment of Erector Spinae Muscles in Patients with Chronic Obstructive Pulmonary Disease. Novel Chest Computed Tomography–derived Index for Prognosis

Abstract: ESMCSA assessed by chest CT may be a valuable clinical parameter, as ESACSA correlates significantly with physiological parameters, symptoms, and disease prognosis.

Cited by 156 publications

References 33 publications

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6‐year follow‐up study

Annual decline in arterial blood oxygen predicts development of chronic respiratory failure in COPD with mild hypoxaemia: A 6‐year follow‐up study

Thoracic muscle cross-sectional area is associated with hospital length of stay post lung transplantation: a retrospective cohort study

Interdependence of physical inactivity, loss of muscle mass and low dietary intake: Extrapulmonary manifestations in older chronic obstructive pulmonary disease patients

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