Quantitative Analysis of the Inner Retinal Layer Thicknesses in Age-Related Macular Degeneration Using Corrected Optical Coherence Tomography Segmentation

Müftüoğlu, İlkay Kılıç; Ramkumar, Hema L.; Bartsch, Dirk-Uwe; Meshi, Amit; Gaber, Raouf; Freeman, William R.

doi:10.1097/iae.0000000000001759

Cited by 37 publications

(62 citation statements)

References 19 publications

(25 reference statements)

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“…Recently, automated segmentation software programmes that enable analysis layers of the retina qualitatively and quantitatively have been introduced [15,16]. Using these softwares, recent studies of AMD eyes have demonstrated that there were a change not only in the outer retinal layers as previously established but also in the inner retina such as the ganglion cell complex (GCC) thickness, which includes GCL and inner plexiform layer (IPL) [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

Nokrashy

Oakley²,

Dubis

et al. 2018

Eye

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Purpose To evaluate longitudinally volume changes in inner and outer retinal layers in early and intermediate age-related macular degeneration (AMD) compared to healthy control eyes using optical coherence tomography (OCT). Methods 71 eyes with AMD and 31 control eyes were imaged at two time points: baseline and after 2 years. Automated OCT layer segmentation was performed using Orion TM. This software is able to measure volumes of retinal layers with distinct boundaries including Retinal Nerve Fibre Layer (RNFL), Ganglion Cell-Inner Plexiform Layer (GCIPL), Inner Nuclear Layer (INL), Outer Plexiform Layer (OPL), Outer Nuclear Layer (ONL), Photoreceptors (PR) and Retinal Pigment Epithelium-Bruch's Membrane complex (RPE-BM). The mean retinal layer volumes and volume changes at 2 years were compared between groups. Results Mean GCIPL and INL volumes were lower, while PR and RPE-BM volumes were higher in AMD eyes than controls at baseline (all P < 0.05) and year 2 (all P < 0.05). In AMD eyes, RNFL and ONL volumes decreased by 0.0232 (P = 0.033) and 0.0851 (P = 0.001), respectively. In contrast, OPL and RPE-BM volumes increased in AMD eyes by 0.0391 (P = 0.000) and 0.0209 (P = 0.000) respectively. Moreover, there were significant differences in longitudinal volume change of OPL (P = 0.02), ONL (P = 0.008) and RPE-BM (P = 0.02) between AMD eyes and controls. Conclusions There were abnormal retinal layer volumes and volume changes in eyes with early and intermediate AMD.

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Section: Introductionmentioning

confidence: 99%

Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

Nokrashy

Oakley²,

Dubis

et al. 2018

Eye

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“…Acquisition of raster scans at high resolution is well tolerated by patients and does generally require fewer skills by the operator as compared to stereoscopic CFP. For quantitative analysis of drusen volume and its changes over time, serial data of various numbers of B-scans are obtained and the borders of the BM/RPE complex are segmented in each B-scan using semi-automated algorithms [19]. Until more reliable and validated algorithms become available, the segmentation in each B-scan must be reviewed and manually corrected as indicated because current semiautomated algorithms are prone to segmentation errors, particularly in eyes with intermediate AMD [19].…”

mentioning

confidence: 99%

“…For quantitative analysis of drusen volume and its changes over time, serial data of various numbers of B-scans are obtained and the borders of the BM/RPE complex are segmented in each B-scan using semi-automated algorithms [19]. Until more reliable and validated algorithms become available, the segmentation in each B-scan must be reviewed and manually corrected as indicated because current semiautomated algorithms are prone to segmentation errors, particularly in eyes with intermediate AMD [19]. Considering future trials on intermediate AMD, larger data sets demand an increasing amount of work and time for analysis of dynamic changes in drusen volume over time.…”

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confidence: 99%

Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns

et al. 2018

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Purpose: To evaluate two different spectral-domain optical coherence tomography (SD-OCT) scan patterns in eyes with intermediate age-related macular degeneration (AMD) for the longitudinal assessment of drusen volume. Methods: The data of 38 eyes of 38 AMD patients (age 69.97 ± 6.08 years) were included. The longitudinal drusen volume over 4 years was analyzed by annual SD-OCT raster scanning (field size 20 × 15°). Two raster scan patterns (A/B) differed in the distance between neighboring B-scans (240 vs. 30 µm) and in the number of averaged frames (4 vs. 15). Results: The mean drusen volume at baseline was 0.213 ± 0.100 mm³ (pattern A) and 0.219 ± 0.103 mm³ (pattern B) (p = 0.937). Linear mixed-effect models showed no significant difference for the change within 4 years for both pattern A (p = 0.8) and pattern B (p = 0.8). Conclusions: The results indicate that the performance of interpolation algorithms may be sufficient to balance for less dense raster scanning with regard to quantification of longitudinal drusen volume, which can be used as a surrogate marker for AMD progression in future clinical trials.

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“…52,53 The GCC was analyzed using automatic segmentation without checking the accuracy of delineation of segmented retinal layers, explaining the high error rate. Recently, Muftuoglu et al 54 also reported GCC changes in patients with severe dry AMD even using the manual correction of segmentation.…”

Section: Discussionmentioning

confidence: 99%

Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

Blanc

Seydou

Ghezala

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate the prevalence of vitreomacular interface abnormalities (VMIAs) in a French elderly glaucomatous population. METHODS. Using a population-based study, the MONTRACHET (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases) study conducted in Dijon from 2009 to 2013 in individuals older than 75 years, the prevalence of VMIAs was estimated on glaucoma patients. RESULTS. A total of 1130 participants (2225 eyes) were included in the study. The mean age of participants was 82.3 6 3.8 years, and 62.74% were women. Regarding the frequency of all VMIAs, there was no statistical difference between glaucoma patients and nonglaucoma participants (51.85% vs. 53.92%, respectively, P ¼ 0.372). In univariate analysis, vitreomacular adherences were more frequent in nonglaucoma participants (18.39% vs. 10.78%, P ¼ 0.036). Epiretinal membranes were more frequent in the glaucomatous population (47.06% vs. 38.13%, P ¼ 0.018). The prevalence of macular cysts was comparable in the two groups (7.84% vs. 5.64%, P ¼ 0.262). Macular cysts were more frequent in eyes treated with preservative-free, IOP-lowering eye drops when compared with the eyes of nonglaucomatous participants treated with IOP-lowering eye drops containing a preservative (26.67% vs. 3.37% and 5.76%, respectively, P < 0.001). In multivariate analysis, these results were no longer significant. CONCLUSIONS. The prevalence of VMIAs was high in this elderly population and similar in both glaucomatous and nonglaucomatous participants. The information provided by macular optical coherence tomography scans should be considered with caution when used for glaucoma management in elderly patients.

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Quantitative Analysis of the Inner Retinal Layer Thicknesses in Age-Related Macular Degeneration Using Corrected Optical Coherence Tomography Segmentation

Cited by 37 publications

References 19 publications

Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

Changes in volume of various retinal layers over time in early and intermediate age-related macular degeneration

Longitudinal Analysis of Drusen Volume in Intermediate Age-Related Macular Degeneration Using Two Spectral-Domain Optical Coherence Tomography Scan Patterns

Vitreomacular Interface Abnormalities and Glaucoma in an Elderly Population (The MONTRACHET Study)

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