Quantitative analysis of neuronal diversity in the mouse olfactory bulb

Parrish-Aungst, S.; Shipley, Michael T.; Erdélyi, Ferenc; Szabó, Gábor; Puché, Adam C.

doi:10.1002/cne.21205

Cited by 307 publications

(476 citation statements)

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“…OB interneurons consist of different subtypes which are variably defined by their spatial distribution, morphological, molecular and functional characteristics (Shipley et al 2004 ;Kosaka et al 1998 ;Kosaka and Kosaka 2005a ;Parrish-Aungst et al 2007 ;Puopolo and Belluzzi 1998 ). Major classes of OB interneurons are located in the GCL and GL.…”

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

“…Major classes of OB interneurons are located in the GCL and GL. The large majority of interneurons in the GCL are GABAergic inhibitory granule cells (GCs; Shipley et al 2004 ;Parrish-Aungst et al 2007 ). The GCL also contains a subpopulation of calretinin (CR) expressing GCs which only partially colocalize with the GABAergic phenotype (Parrish-Aungst et al 2007 ).…”

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

“…The large majority of interneurons in the GCL are GABAergic inhibitory granule cells (GCs; Shipley et al 2004 ;Parrish-Aungst et al 2007 ). The GCL also contains a subpopulation of calretinin (CR) expressing GCs which only partially colocalize with the GABAergic phenotype (Parrish-Aungst et al 2007 ). In contrast to the limited number of neurochemically distinct GC types, periglomerular (PG) cells are highly heterogeneous in neurochemical content.…”

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

“…In contrast to the limited number of neurochemically distinct GC types, periglomerular (PG) cells are highly heterogeneous in neurochemical content. A recent quantitative analysis performed in the mouse OB shows that about 50% of all cells in the GL are GABAergic (Parrish-Aungst et al 2007 ). The GABAergic population comprises a subpopulation expressing dopamine or its synthesizing key enzyme tyrosine hydroxylase (TH) that account for about 10-13% of all glomerular neurons (Kosaka and Kosaka 2005b ).…”

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

“…At least three further non-overlapping GL neurochemical classes can be identified by the expression of different calciumbinding protein, namely CR, calbindin (CB) and neurocalcin (NC) (Kosaka et al 1998 ;Kosaka and Kosaka 2005b ). Similarly to the TH population also CB expressing cells are largely GABAergic, whereas CR and NC show only low colocalization with GAD (Parrish-Aungst et al 2007 ). Recently, it is becoming more and more accepted that a certain degree of heterogeneity already exists in OB interneuron precursors migrating along the RMS.…”

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

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Spatio-temporal specification of olfactory bulb interneurons

et al. 2007

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Olfactory bulb (OB) interneurons are continuously generated throughout development and in adulthood, and are derived from different progenitor zones. Once integrated in the OB circuits, interneurons play essential roles in olfactory information processing by modulating the activity of major output neurons. These functions are performed by multiple classes of neurons that differ in their spatial distribution, morphology, neurochemical and synaptic properties. This diversity, and the continuous neurogenesis make the understanding of the specification mechanisms in the OB a challenging task. New studies suggest that both intrinsic and extrinsic cues are involved in fate determination of OB interneurons. In both development and adulthood the expression of specific transcription factors not only defines different progenitor regions but also precise interneuronal phenotypes. Here we discuss recent findings on the molecular mechanisms regulating production and diversity of OB interneurons with respect to the spatial and temporal parameters.

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Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

Section: Heterogeneity Of the Ob Interneuronsmentioning

confidence: 99%

See 3 more Smart Citations

Spatio-temporal specification of olfactory bulb interneurons

et al. 2007

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Olfactory Bulb: Synaptic Organisation

Lowe

2013

Encyclopedia of Life Sciences

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Odour information is encoded by sensory neurons expressing a large family of ∼10 2 –10 3 distinct olfactory receptors, and is mapped to an equally numerous population of glomeruli in the olfactory bulb. Each glomerulus is a modular circuit composed of a variety of local interneurons and bulb output neurons that receive primary afferent signals encoded by a single olfactory receptor. Incoming signals are filtered by inhibition from periglomerular cells and amplified by mutual excitation of mitral and tufted cells. Odour codes are further transformed by lateral inhibition between glomeruli mediated by short axon and granule cells that communicate through specialised dendrodendritic reciprocal synapses. These network mechanisms interact with a diversity of cell biophysical properties to shape spiking patterns of bulb output neurons. Synaptic processing in the bulb is also dynamically regulated by feedback from olfactory cortex, centrifugal modulation from basal forebrain nuclei and plasticity of local circuits sustained by adult neurogenesis. Key Concepts: Odour information is mapped to discrete glomeruli in the olfactory bulb that receive sensory inputs encoded by different olfactory receptors. Sensory neuron terminals in glomeruli release the excitatory transmitter glutamate, under control of presynaptic inhibition by dopamine and GABA receptors. Glomeruli contain multiple excitatory and inhibitory circuits for coordinating odour‐evoked spike activity of bulb output neurons, the mitral and tufted cells. Most olfactory bulb circuits include dendrodendritic reciprocal synapses with closely linked glutamatergic excitatory and GABAergic inhibitory transmission. Mitral and tufted cell responses are triggered and amplified by dendrodendritic excitation of glomerular dendritic tufts, and are controlled by periglomerular cell inhibition. Glomeruli are connected by pervasive short‐ and long‐range networks of inhibitory superficial short axon cells. Granule cells form complex webs of lateral inhibitory connections between mitral and tufted cells of different glomeruli. Synaptic inhibition in the bulb is coordinated by networks of deep short axon cells that inhibit periglomerular and granule cells. Synaptic inhibition in the bulb is strongly influenced by centrifugal inputs from olfactory cortex and subcortical modulatory centres.

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