Quantifying coronary artery calcification from a contrast-enhanced cardiac computed tomography angiography study

Mylonas, Ilias; Alam, Mohammed S.; Amily, Noor; Small, Gary; Chen, Li; Yam, Yeung; Hibbert, Benjamin; Chow, Benjamin J.W.

doi:10.1093/ehjci/jet144

Cited by 48 publications

(40 citation statements)

References 16 publications

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“…Subsequently, aortic leaflet calcification was measured in a region starting from the aortic annulus to 20 mm above that, marking the most cranial aspect of the aortic leaflets. Because of the interpatient difference in the amount of contrast used for contrast-enhanced MSCT, the threshold for detecting calcification in the aortic valve apparatus was chosen on an individual basis, using the method described by Mylonas et al [15] for quantification of coronary artery calcification: for each patient, using axial images, a region of Fig. 1 Cerebral arterial territory.…”

Section: Patient Population and Tavr Proceduresmentioning

confidence: 99%

Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors

et al. 2015

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Aims Silent ischemic brain lesions and ischemic stroke are known complications of transcatheter aortic valve replacement (TAVR). We aimed to investigate the occurrence and distribution of TAVR-related silent ischemic brain lesions using diffusion-weighted magnetic resonance imaging (DWI). Methods Consecutive patients with severe aortic valve stenosis treated with TAVR underwent cerebral DWI within 5 days after the index procedure. DWI scans were analyzed for the occurrence and distribution of new ischemic lesions post-TAVR. Results Forty-two patients were enrolled in this study. After TAVR, a total of 276 new cerebral ischemic lesions were detected in 38 (90 %) patients, with a median of 4.5 (interquartile range 2.0-7.0) lesions per patient. A total of 129 (47 %) lesions were detected in the cortical regions, 97 (35 %) in the subcortical regions, and 50 (18 %) in the cerebellum or brainstem. The median lesion volume was 20.2 ll (10.0, 42.7) and the total ischemic lesion volume was 132.3 ll (42.8, 336.9). The new ischemic brain lesions were clinically silent in 37 (97 %) patients; the other patient had a transient ischemic attack. Age (B = 0.528, p = 0.015), hyperlipidaemia (B = 5.809, p = 0.028) and post-dilatation of the implanted prosthesis (B = 7.196, p = 0.029) were independently associated with the number of post-TAVR cerebral DWI lesions. In addition, peak transaortic gradient was independently associated with post-procedural total infarct volume. Conclusion Clinically silent cerebral infarcts occurred in 90 % of patients following TAVR, most of which were small (\20 ll) and located in the cortical regions of the cerebral hemispheres. An independent association was found between age, hyperlipidaemia and balloon postdilatation and the number of post-TAVR ischemic brain lesions. Only peak transaortic gradient was independently associated with post-procedural total infarct volume.

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Section: Patient Population and Tavr Proceduresmentioning

confidence: 99%

Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors

et al. 2015

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“…Several previous studies have focused on the feasibility of assessing and computing the CAC scores from contrast CTA images [18][19][20][21][22]35]. The main challenge in all these studies was to establish an accurate method to differentiate between CAC and coronary artery luminal contrast.…”

Section: Different Methods For Quantification Of Cac Score On Contrasmentioning

confidence: 99%

“…5. Based on the detected CAC volumes for each of the four main coronaries and side-branches, the Agatston CAC score was automatically calculated using a predefined conversion factor of 2.74 [19].…”

Section: Cardiac Ct and Cta Acquisitionmentioning

confidence: 99%

“…To adapt for this difference, a conversion factor is required. This factor was previously established by Mylonas et al [19]. For this purpose, 92 patients underwent both a non-contrast CT scan and contrast CTA scan to measure CAC.…”

Section: Contrast Cta Conversion Factormentioning

confidence: 99%

“…If Agatston CAC score calculation on contrast CTA images is accurately achievable, it could result in making a separate non-contrast CT scan superfluous, hence resulting in a decrease in cost, time and radiation exposure. Previous studies have addressed this topic, aiming to assess the potential of software tools to quantify CAC on CTA datasets, however, these algorithms required (partial) manual interference or provided moderate results [18][19][20][21][22]. Recently, using a novel software algorithm, fully automatic quantification of the Agatston CAC score on contrast CT has become feasible.…”

Section: Introductionmentioning

confidence: 99%

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Automatic detection and quantification of the Agatston coronary artery calcium score on contrast computed tomography angiography

Ahmed

Graaf

Broersen

et al. 2014

Int J Cardiovasc Imaging

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Potentially, Agatston coronary artery calcium (CAC) score could be calculated on contrast computed tomography coronary angiography (CTA). This will make a separate non-contrast CT scan superfluous. This study aims to assess the performance of a novel fully automatic algorithm to detect and quantify the Agatston CAC score in contrast CTA images. From a clinical registry, 20 patients were randomly selected for each CAC category (i.e. 0, 1-99, 100-399, 400-999, ≥1,000). The Agatston CAC score on non-contrast CT was calculated manually, while the novel algorithm was used to automatically detect and quantify Agatston CAC score in contrast CTA images. The resulting Agatston CAC scores were validated against the non-contrast images. A total of 100 patients (60 ± 11 years, 63 men) were included. The median CAC score on non-contrast CT was 145 (IQR 5-760), whereas the contrast CTA CAC score was 170 (IQR 23-594) (P = 0.004). The automatically computed CAC score showed a high correlation (R = 0.949; P < 0.001) and intra-class correlation (R = 0.863; P < 0.001) with non-contrast CT CAC score. Moreover, agreement within CAC categories was good (κ 0.588). Fully automatic detection of Agatston CAC score on contrast CTA is feasible and showed high correlation with non-contrast CT CAC score. This could imply a radiation dose reduction and time saving by omitting the non-contrast scan.

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Artificial Intelligence-Based Evaluation of Coronary Calcium

Velzen

Hampe

Vos

et al. 2022

Artificial Intelligence in Cardiothoracic Imaging

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Quantifying coronary artery calcification from a contrast-enhanced cardiac computed tomography angiography study

Abstract: Quantification of CAC from a single contrast-enhanced CCTA scan is feasible and correlates well with Standard-CAC. Larger, multicentre studies are needed to validate the universal applicability of CAC quantified using CCTA.

Cited by 48 publications

References 16 publications

Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors

Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors

Automatic detection and quantification of the Agatston coronary artery calcium score on contrast computed tomography angiography

Artificial Intelligence-Based Evaluation of Coronary Calcium

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