Quantifying axonal loss after optic neuritis with optical coherence tomography

Costello, Fiona; Coupland, Stuart G.; Hodge, W.G.; Lorello, Gianni R.; Koroluk, J.; Pan, Yi; Freedman, Mark S.; Zackon, David H.; Kardon, Randy H.

doi:10.1016/j.ajo.2006.08.009

Cited by 209 publications

(335 citation statements)

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“…When eyes that had never been affected by optic neuritis were assessed in the present study, 21% of them presented thinning of the RNFL. Similar findings have also been reported by other authors, as reviewed by Kallenbach and Frederiksen 19 .…”

Section: Resultssupporting

confidence: 80%

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Fragoso

Nosé

Nosé³

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To assess the visual quality of life in patients with multiple sclerosis (MS), and to observe whether this parameter could be correlated to the findings of the ophthalmologic examination. Method: The translated and validated 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was used to assess the visual quality of life. Clinical data on MS, visual acuity, visual fields, optic coherence tomography (OCT) and disc cupping were used for assessing correlation with VFQ-25. Results: The mean VFQ-25 value was 78.6±18.2% in 27 patients. VFQ-25 did not correlate with patients' ages, with disability (EDSS), disease duration or medication use. Visual acuity showed a relatively poor (<60%) correlation to VFQ-25, while no correlation could be established between visual fields, OCT and disc cupping with VFQ-25. Conclusion: MS patients present several alterations in their eyes and sight that cannot be assessed by isolated measures. Ophthalmological examination of these patients must include many parameters not usually used in standard ophthalmologic consultations. Key words: multiple sclerosis, ophthalmology, visual acuity, visual fields, optic coherence tomography, quality of life.Qualidade de vida visual e achados oftálmicos em um grupo de pacientes brasileiros com esclerose múltipla RESUMO Objetivo: Avaliar a qualidade de vida visual de pacientes com esclerose múltipla (EM) e observar se este parâmetro pode ser relacionado aos achados do exame oftalmológico. Método: O questionário traduzido e validado 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) foi utilizado para avaliar a qualidade de vida visual. Dados clínicos da EM, acuidade visual, campo visual, tomografia de coerência óptica (OCT) e escavação do disco foram utilizados para correlação com VFQ-25. Resultados: A média do VFQ-25 foi 78,6±18,2% em 27 pacientes. VFQ-25 não se correlacionou com a idade dos pacientes, com a incapacidade (EDSS), duração da doença ou medicação em uso. A acuidade visual mostrou uma correlação relativamente pobre (<60%) com VFQ-25, enquanto não foi observada nenhuma correlação entre campo visual, OCT e escavação de disco com VFQ-25. Conclusão: Pacientes com EM apresentam diversas alterações oculares e na visão que não podem ser avaliadas por medidas isoladas. O exame oftalmológico destes pacientes deve incluir parâmetros que não são habitualmente utilizados em consultas oftalmológicas padronizadas. Palavras-Chave: esclerose múltipla, oftalmologia, acuidade visual, campo visual, tomografia de coerência óptica, qualidade de vida.

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Section: Resultssupporting

confidence: 80%

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Fragoso

Nosé

Nosé³

et al. 2011

Arq. Neuro-Psiquiatr.

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“…It is known that thinning of the RNFL below 75 mm (injury threshold) might lead to a corresponding decline in objective visual function. 31 Whereas healthy subjects have a tendency to age-related RNFL thinning, MS patients can likely pass through different stages of retinal thinning and thickening, which might be the reason why we could not find any statistically significant change between the baseline and second measurements in our MS patients. Even so, the MS patients in our cohort had a mean annual rate of average RNFL change of À1.17 (95% CI: À2.27 to 4.74) similar to the results reported in previous studies.…”

Section: Discussioncontrasting

confidence: 44%

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Huseyinoglu¹,

Özben²,

Ekinci

et al. 2013

Neuro-Ophthalmology

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Optical coherence tomography is supported and used as a technique for visualisation of neuro-axonal loss in multiple sclerosis, but there are also a few studies expressing the opposite view. The aim of our study was to investigate retinal nerve fibre layer and optic nerve head parameters in patients with multiple sclerosis without a history of prior optic neuritis and symptoms of a new clinical attack during the follow-up for a total of 20-month period. Full ophthalmic evaluation was performed for all of the participants. The baseline retinal nerve fibre layer and macular thicknesses and focal and global loss of macular volume values were significantly lower in the eyes of the patients with multiple sclerosis compared with the healthy controls. No significant change between baseline and follow-up scans were found in all optical coherence tomography parameters in the multiple sclerosis group. Statistical analyses revealed significant retinal nerve fibre layer and macular thickness differences between baseline and second measurements in the controls. No significant difference in percent change between baseline and second measurements was observed between the patient and control groups. We conclude that whereas healthy subjects have an age-related tendency toward a decrease in retinal nerve fibre layer thickness, patients with multiple sclerosis patients are likely to pass through different stages of retinal thinning and thickening due to subclinical optic neuritis and, as a result, we could not detect any statistically significant change between baseline and second measurements in our multiple sclerosis patients.

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“…Studies with optic coherence tomography have demonstrated axonal loss in the retinal nerve fiber layer in patients with MS in the early stages of the disease [30][31][32]. This early axonal loss is probably the reason why most of our patients with subsequent MS conversion had incomplete recovery after the first clinical presentation of the disease.…”

Section: Discussionmentioning

confidence: 99%

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

Marques

Matias

Silva

et al. 2014

Journal of Clinical Neuroscience

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a b s t r a c tWhen assessing and managing a patient with optic neuritis (ON), the risk of future development of multiple sclerosis (MS) is an important issue, as this can be the first presentation of the disease. Although the presence of lesions on baseline brain MRI is the strongest predictor of MS conversion, some patients with normal imaging also develop MS. We aimed to estimate MS risk in patients with ON and a normal baseline MRI and identify individuals with higher risk of conversion. We performed a retrospective study including patients with idiopathic ON and normal baseline brain MRI who presented to our hospital over an 8 year period. Of a total of 42 patients, 10 converted to MS: five during the first follow-up year, seven during the first 2 years and all of the patients within the first 5 years, with a 5 year MS conversion rate of 23.8%. MS conversion rates were significantly higher in patients with history of previous symptoms suggestive of demyelination (p = 0.002), cerebrospinal fluid oligoclonal bands unmatched in serum (p = 0.004) and incomplete visual acuity recovery (66/12) after 1 year (p = 0.002). Lower conversion rates were found in patients with optic disc edema (p = 0.022). According to these results, a significant proportion of patients with idiopathic ON and a normal baseline brain MRI will develop MS, with a higher risk during the first 5 years. Therefore, in the presence of factors in favor of MS conversion, close follow-up, including semestral medical consultations and yearly brain MRI, can be recommended. Early immunomodulatory treatment may be individually considered as it can delay conversion and reduce new lesion development rate.

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Quantifying axonal loss after optic neuritis with optical coherence tomography

Cited by 209 publications

References 0 publications

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Sight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis

Optical Coherence Tomography in Patients with Relapsing-Remitting Multiple Sclerosis without Optic Neuritis: A 20-Month Longitudinal Study

Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI

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