volume 93, issue 0, P2-P-183 2020
DOI: 10.1254/jpssuppl.93.0_2-p-183
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Abstract: Food-derived antioxidant ergothioneine (ERGO) is not synthesized in mammals, but ingested from daily diet. After oral administration, ERGO is efficiently absorbed in gastrointestinal tract and distributed to the brain parenchyma via transporter SLC22A4, implying its fundamental role in the brain. Oral administration of ERGO actually enhances learning and memory in mice at least in part through activation of tropomyosin receptor kinases B (TrkB), a receptor for neurotrophins. Therefore, we hypothesized that amo…

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