Quantification of angiogenic factors and their clinicopathological associations in breast cancer

Karimzadeh, Parisa; Faghih, Zahra; Rahmani, Negin; Eghbali, Fatemeh Sadegh; Razmkhah, Mahboobeh

doi:10.1684/ecn.2020.0447

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Using the proteome profiler array approximation, in patients with COVID-19 we confirmed the angiogenic and chemotactic serum profile compared to healthy volunteers of similar ages. Of the 55 molecules analysed, the observed increase in insulin-like growth factor binding proteins (IGFBPs), chemokines such as CXCL16 and Pentraxin-3, and endothelial growth factor (EGF) reaffirms the upregulation of angiogenic factors ( 34 – 39 ). There is compelling evidence that there is a need for crosstalk between different factors, as this has been described between HGF and VEGF, enhancing VEGF-driven angiogenesis; therefore, an increase in different molecules was expected ( 40 ).…”

Section: Discussionmentioning

confidence: 87%

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

et al. 2022

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PurposeEndothelial damage and angiogenesis are fundamental elements of neovascularisation and fibrosis observed in patients with coronavirus disease 2019 (COVID-19). Here, we aimed to evaluate whether early endothelial and angiogenic biomarkers detection predicts mortality and major cardiovascular events in patients with COVID-19 requiring respiratory support.MethodsChanges in serum syndecan-1, thrombomodulin, and angiogenic factor concentrations were analysed during the first 24 h and 10 days after COVID-19 hospitalisation in patients with high-flow nasal oxygen or mechanical ventilation. Also, we performed an exploratory evaluation of the endothelial migration process induced by COVID-19 in the patients' serum using an endothelial cell culture model.ResultsIn 43 patients, mean syndecan-1 concentration was 40.96 ± 106.9 ng/mL with a 33.9% increase (49.96 ± 58.1 ng/mL) at day 10. Both increases were significant compared to healthy controls (Kruskal–Wallis p < 0.0001). We observed an increase in thrombomodulin, Angiopoietin-2, human vascular endothelial growth factor (VEGF), and human hepatocyte growth factor (HGF) concentrations during the first 24 h, with a decrease in human tissue inhibitor of metalloproteinases-2 (TIMP-2) that remained after 10 days. An increase in human Interleukin-8 (IL-8) on the 10th day accompanied by high HGF was also noted. The incidence of myocardial injury and pulmonary thromboembolism was 55.8 and 20%, respectively. The incidence of in-hospital deaths was 16.3%. Biomarkers showed differences in severity of COVID-19. Syndecan-1, human platelet-derived growth factor (PDGF), VEGF, and Ang-2 predicted mortality. A multiple logistic regression model with TIMP-2 and PDGF had positive and negative predictive powers of 80.9 and 70%, respectively, for mortality. None of the biomarkers predicted myocardial injury or pulmonary thromboembolism. A proteome profiler array found changes in concentration in a large number of biomarkers of angiogenesis and chemoattractants. Finally, the serum samples from COVID-19 patients increased cell migration compared to that from healthy individuals.ConclusionWe observed that early endothelial and angiogenic biomarkers predicted mortality in patients with COVID-19. Chemoattractants from patients with COVID-19 increase the migration of endothelial cells. Trials are needed for confirmation, as this poses a therapeutic target for SARS-CoV-2.

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Section: Discussionmentioning

confidence: 87%

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

et al. 2022

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“…PDGF-α has been associated with lymphangiogenesis and angiogenesis in gliomas, sarcomas, leukemias, and epithelial cancers [ 35 , 36 ]. PDGF-α and VEGF expression has been associated with poor prognosis in many malignant tumors [ 37 , 38 ]. HCC cells secrete PDGF-α and VEGF to facilitate cell proliferation, migration, and invasion [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Tian

Luan

et al. 2021

Cell Death Discov.

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In China, hepatocellular carcinoma (HCC) is considered a malignant tumor with poor prognosis, frequent metastasis, and a high relapse rate. Telocytes (TCs) participate in tumorigenic, invasive, and migratory processes by secreting functional proteins and transmitting cell-to-cell information, but their functions in HCC are still unknown. TC counts and MMP9 expression in liver cancer tissues were measured using immunohistochemistry, western blotting, and RT-PCR. Primary TCs from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in HCC, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo. TCs promoted HCC cell metastasis by MMP9 expression in vitro and in vivo. Platelet-derived growth factor-alpha (PDGF-α), secreted by HCC cells, activated the Ras/ERK signaling pathway in TCs, thereby increasing MMP9 expression; Moreover, miR-942-3p suppressed MMP9 expression in TCs. Our results reveal the role of TCs in HCC and the mechanisms by which they elicit their effects, and they may serve as novel prognostic markers for HCC.

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“…Breast cancer is a vascular-dependent disease, and the differences in CEUS enhancement patterns between breast cancer lesions and the surrounding normal breast tissue are closely related to their blood perfusion and pathological characteristics. The higher the histological grade of breast cancer, the poorer the differentiation, the higher the degree of malignancy, and the more angiogenesis ( 12 ). The distribution of blood vessels in malignant tumors is uneven; there are abundant tortuous and dilated blood vessels at the edges of lesions, and immature, stenotic, and occluded new blood vessels are common, resulting in heterogeneous enhancement within the tumors ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasound for the preoperative prediction of pathological characteristics in breast cancer

Li,

Su,

Deng

et al. 2024

Front. Oncol.

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ObjectiveWe aimed to investigate the value of contrast-enhanced ultrasound (CEUS) in the preoperative prediction of the histological grades and molecular subtypes of breast cancer.MethodsA total of 183 patients with pathologically confirmed breast cancer were included. Contrast enhancement patterns and quantitative parameters were compared in different groups. The receiver operating characteristic (ROC) curve was used to analyze the efficacy of CEUS in the preoperative prediction of pathological characteristics, including histologic grade and molecular subtypes.ResultsHeterogeneous enhancement, perfusion defects, and peripheral radial vessels were mostly observed in higher histologic grade (grade III) breast cancer. Heterogeneous enhancement and perfusion defect were the most effective indicators for grade III breast cancer, with the areas under the ROC curve of 0.768 and 0.756, respectively. There were significant differences in the enhancement intensity, post-enhanced margin, perfusion defects, and peripheral radial vessel among the different molecular subtypes of breast cancer (all P < 0.01). Perfusion defects and clear edge after enhancement were the best qualitative criteria for the diagnosis of HER-2 overexpressed and triple-negative breast cancers, and the corresponding areas under the ROC curves were 0.804 and 0.905, respectively. There were significant differences in PE, WiR, WiPI, and WiWoAUC between grade III vs grade I and II breast cancer (P < 0.05). PE, WiR, WiPI, and WiWoAUC had good efficiency in the diagnosis of high-histologic-grade breast cancer. PE had the highest diagnostic efficiency in Luminal A, while WiPI had the highest diagnostic efficiency in Luminal B subtype breast cancer, and the areas under the ROC curve were 0.825 and 0.838, respectively. WiWoAUC and WiR were the most accurate parameters for assessing triple-negative subtype breast cancers, and the areas under the curve were 0.932 and 0.922, respectively.ConclusionQualitative and quantitative perfusion analysis of contrast-enhanced ultrasound may be useful in the non-invasive prediction of the histological grade and molecular subtypes of breast cancers.

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Quantification of angiogenic factors and their clinicopathological associations in breast cancer

Cited by 5 publications

References 33 publications

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis

Contrast-enhanced ultrasound for the preoperative prediction of pathological characteristics in breast cancer

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