2021
DOI: 10.1590/acb361001
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Quantification of adhesion of mesenchymal stem cells spread on decellularized vein scaffold

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Cited by 3 publications
(4 citation statements)
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“…The most suitable scaffolds for tissue engineering of blood vessels should be able to withstand vascular stress without degeneration, do not promote thrombotic events, present good interaction with adjacent tissues and implanted cells, and enable nutrient transport through the porosity of their wall until they are fully developed [ 20 ]. More than one of our previous studies [ 15 ] have determined that the method used in the production of a biological scaffold produced by the decellularization of the vena cava in the rabbit model meets these requirements, and the current study demonstrates that the interaction with autologous ASCs promotes a favorable environment, generating the ideal adaptive conditions when it is implanted on the animal’s back.…”
Section: Discussionmentioning
confidence: 75%
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“…The most suitable scaffolds for tissue engineering of blood vessels should be able to withstand vascular stress without degeneration, do not promote thrombotic events, present good interaction with adjacent tissues and implanted cells, and enable nutrient transport through the porosity of their wall until they are fully developed [ 20 ]. More than one of our previous studies [ 15 ] have determined that the method used in the production of a biological scaffold produced by the decellularization of the vena cava in the rabbit model meets these requirements, and the current study demonstrates that the interaction with autologous ASCs promotes a favorable environment, generating the ideal adaptive conditions when it is implanted on the animal’s back.…”
Section: Discussionmentioning
confidence: 75%
“…Decellularization was carried out using the protocol with 1% SDS for 2 h under shaking in a Shaker (News Brunswick Scientific ® Edison, NJ, USA), at 37 °C. ( Supplementary file S1 ) [ 9 , 13 , 15 ]. The fragments were stored in a refrigerator at 4 °C in a sterile solution containing antibiotics and fungicide.…”
Section: Methodsmentioning
confidence: 99%
“…When using biological scaffolds, the native architecture is highly preserved, and the antigen content is removed during the decellularization process [ 41 , 42 , 43 ]. The use of decellularized veins as biological scaffolds for tissue engineering in blood vessels was chosen as a biocompatible, resistant, and adaptable 3D tubular structure, which had good results in cell culture in experiments previously carried out by our study team [ 44 , 45 , 46 , 47 , 48 , 49 ].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the physicochemical signals remain intact for regulating cell adhesion, proliferation, and differentiation, thus, providing a superior substrate for MSC seeding [ 7 ]. The scaffold produced through venous decellularization has biomechanical properties sufficient to resist the stresses of the urinary system and offers an extracellular matrix favorable to the cell population [ 12 , 13 , 14 ]. Tissue engineering research for the production and replacement of urinary bladder tissue has grown in recent decades; however, the clinical applications have not been completely established [ 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%