2006
DOI: 10.1007/s00259-006-0294-0
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Abstract: A three-compartment model with a reference region, the centrum semiovale, describes the kinetic behaviour of [(11)C]TMSX PET images. A2ARs in the human brain can be visualised as a BP image using [(11)C]TMSX PET without arterial blood sampling.

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Cited by 32 publications
(78 citation statements)
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“…Similar BP ND values were obtained when using noninvasive quantification methods. Previous human studies with successful A 2A PET imaging agents, namely 11 C-SCH442416 and 11 C-TMSX, have reported BP ND values in the caudate and putamen of around 0.5 to 1.1 and 1.0 to 1.3, respectively (21)(22). Our BP ND results obtained using 123 I-MNI-420 SPECT are in line with the results previously reported using these PET agents, demonstrating that the new radiotracer 123 I-MNI-420 holds promise as an A 2A imaging probe.…”
Section: Discussionmentioning
confidence: 99%
“…Similar BP ND values were obtained when using noninvasive quantification methods. Previous human studies with successful A 2A PET imaging agents, namely 11 C-SCH442416 and 11 C-TMSX, have reported BP ND values in the caudate and putamen of around 0.5 to 1.1 and 1.0 to 1.3, respectively (21)(22). Our BP ND results obtained using 123 I-MNI-420 SPECT are in line with the results previously reported using these PET agents, demonstrating that the new radiotracer 123 I-MNI-420 holds promise as an A 2A imaging probe.…”
Section: Discussionmentioning
confidence: 99%
“…3 Because of the low V T in the centrum semiovale, supported by the findings in a postmortem study showing negligibly low A 2A R density in corresponding regions, 8 centrum semiovale was regarded as the optimal reference region for future studies. 3 Also in the following study, 4 the V T was reported to be higher in cerebellum than in cerebral cortices, and the same order of magnitude was observed in BP ND estimation using the centrum semiovale as the reference region.…”
Section: Discussionmentioning
confidence: 99%
“…3 Because of the low V T in the centrum semiovale, supported by the findings in a postmortem study showing negligibly low A 2A R density in corresponding regions, 8 centrum semiovale was regarded as the optimal reference region for future studies. 3 Also in the following study, 4 the V T was reported to be higher in cerebellum than in cerebral cortices, and the same order of magnitude was observed in BP ND estimation using the centrum semiovale as the reference region. The rate of specific binding (SB, calculated as BP/V T ) of [ 11 C]TMSX was reported to exceed 30% in the cerebellum (53.0%) and cerebral cortex (37.8 in frontal, percentage, 42.1% in temporal, 42.7% in occipital, and 40.6% in parietal lobe) in addition to the high SB in the striatum (caudate nucleus 58.4%, anterior putamen 62.7%, posterior putamen 61.8%).…”
Section: Discussionmentioning
confidence: 99%
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