Quality of life, support and smoking in advanced lung cancer patients: a qualitative study

Rowland, Christine; Danson, Sarah; Rowe, Richard; Merrick, Hannah; Woll, Penella J.; Hatton, Matthew; Wadsley, Jonathan; Ellis, Sue; Crabtree, Carol; Horsman, Janet; Eiser, Christine

doi:10.1136/bmjspcare-2013-000589

Cited by 13 publications

(18 citation statements)

References 30 publications

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“…The importance of capturing and including HRQL data in LC drug development and treatment decision-making has been highlighted by several previous empirical and literature studies. Particularly, the categories identified in the present study related to physical, emotional, and social impact on HRQL were also revealed in a qualitative interview study by Rowland et al (2016) . Regarding psychological aspects, He et al (2019) examined the role of LC patients’ mood in influencing their HRQL and concluded that interventions that facilitate adaptive coping, reduce negative mood, and enhance positive mood could help to improve or maintain HRQL in patients with advanced LC.…”

Section: Discussionsupporting

confidence: 63%

Key Determinants of Health-Related Quality of Life Among Advanced Lung Cancer Patients: A Qualitative Study in Belgium and Italy

et al. 2021

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Background: The lung cancer (LC) treatment landscape has drastically expanded with the arrival of immunotherapy and targeted therapy. This new variety of treatment options, each with its own characteristics, raises uncertainty regarding the key aspects affecting patients’ health-related quality of life (HRQL). The present qualitative study aimed to investigate how LC patients perceive their HRQL and the factors that they consider to be most influential in determining their HRQL.Methods: This qualitative research incorporates four focus group discussions, with six LC patients in each group. In total, 24 stage III and IV LC patients were included in the discussions, with Italian (n = 12) and Belgian (n = 12) patients, age range: 42–78, median age = 62 (IQR = 9.3 years), SD = 8.5; 62% men. Using thematic analysis, transcripts and notes from the FGDs were analyzed using NVivo software (edition 12).Results: Three main themes capturing determinants of HRQL were identified. First, patients agreed on the importance of physical aspects (symptoms and side-effects) in determining their HRQL. In particular, skin conditions, nausea, fatigue, risk of infections, sensory abnormalities, pain, and changes in physical appearance were highlighted. Second, patients worried about psychological aspects, negatively impacting their wellbeing such as uncertainties regarding their future health state, and a lower degree of autonomy and independence. Third, patients underlined the importance of social aspects, such as communication with healthcare providers and social interaction with friends, family and peers.Conclusion: This study demonstrates that physical, psychological, and social aspects are key factors driving LC patients’ HRQL. Gaining a better understanding of how LC patients perceive their HRQL and how it is affected by their illness and therapy will aid patient-centric decision-making across the drug life cycle, by providing stakeholders (drug developers, regulators, reimbursement bodies, and clinicians) insights about the treatment and disease aspects of importance to LC patients as well as the unmet needs LC patients may have regarding available treatment modalities. Finally, this study underscores a need for individual treatment decision-making that is considerate of uncertainties among LC patients about their future health state, and ways for improving communication between healthcare providers and patients to do so.

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Section: Discussionsupporting

confidence: 63%

Key Determinants of Health-Related Quality of Life Among Advanced Lung Cancer Patients: A Qualitative Study in Belgium and Italy

et al. 2021

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“…For example, smoking reduces erlotinib bioavailability [90,91]. Given the established relationship between smoking and lung cancer, patients who have smoked may feel stigmatised or guilty after diagnosis and more pessimistic about their illness and likely outcomes, all of which may have adverse implications for health-related quality of life (QoL) [92].…”

Section: Management Of Advanced/metastatic Nsclcmentioning

confidence: 99%

Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

et al. 2018

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“…Only the studies by Cohen et al 34 and Osborne et al 47 included all eight aspects. All but one study reported that spiritual, physical, and social aspects were important, whereas only a quarter 36 Goldsteen 2006 37 Gott 2008 38 Gourdji 2009 39 Greisinger 1997 40 Jansen van Rensburg 2013 41 Kim 2009 42 Locker 2015 43 Masson 2002 44 Melin Johansson 2006 45 Melin Johansson 2008 46 Osbourne 2014 47 Payne 1996 48 Pierson 2002 49 Rowland 2014 50 Sherman 2001 51 Steinhauser 2000 52 Stridsman 2015 53 Treloar 2009 54 Vig 2003 55 Willems 2004 56Shaded cells represent important aspects included in the study.…”

Section: Aspects Quality Of Life Important From Palliative Care Patiementioning

confidence: 99%

What Aspects of Quality of Life Are Important From Palliative Care Patients' Perspectives? A Systematic Review of Qualitative Research

McCaffrey

Bradley

Ratcliffe

et al. 2016

Journal of Pain and Symptom Management

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A broad range of domains are important to the QOL of people with life-limiting illnesses receiving palliation. Refinement of measures is needed to help ensure services address issues valued by patients such as preparation for death and aspects of health care provision, elements which are seldom included in currently available preference-based measures used to inform value for money decisions in palliative care.

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Quality of life, support and smoking in advanced lung cancer patients: a qualitative study

Abstract: We conclude that staff should give clearer advice about the adverse implications of continued smoking. We discuss the potential value of diagnosis as a teachable moment for promoting smoking cessation among patients and family members.

Cited by 13 publications

References 30 publications

Key Determinants of Health-Related Quality of Life Among Advanced Lung Cancer Patients: A Qualitative Study in Belgium and Italy

Key Determinants of Health-Related Quality of Life Among Advanced Lung Cancer Patients: A Qualitative Study in Belgium and Italy

Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

What Aspects of Quality of Life Are Important From Palliative Care Patients' Perspectives? A Systematic Review of Qualitative Research

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