Quality of life in older Belgian people: comparison between people with dementia, mild cognitive impairment, and controls

Missotten, Pierre; Squelard, Gilles; Ylieff, Michel; Notte, David Di; Paquay, Louis; Lepeleire, Jan De; Fontaine, Ovide

doi:10.1002/gps.1981

Cited by 69 publications

(71 citation statements)

References 47 publications

(72 reference statements)

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“…Studies in non-PD populations have similarly found no difference in global scores of HR-QOL between patients with MCI and normal controls [12,31,32]. While most dimensions were unaffected in these studies there were differences in select psychological dimensions, as we found in our study of PD patients.…”

Section: Discussioncontrasting

confidence: 35%

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Reginold

Duff‐Canning

Meaney

et al. 2013

Dement Geriatr Cogn Disord

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Background/Aims: To assess the impact of mild cognitive impairment (MCI) or cognitive decline on health-related quality of life (HR-QOL) in Parkinson's disease (PD). Methods: HR-QOL measured by the Parkinson Disease Quality of Life Questionnaire (PDQ-39), MCI according to Movement Disorder Society Task Force criteria and cognitive decline from premorbid baseline were assessed in non-demented PD patients at 6 movement disorder clinics. Results: Among 137 patients, after adjusting for education, gender, disease duration, and Movement Disorder Society Unified Parkinson's Disease Rating Scale total score, MCI was associated with worse scores within the PDQ-39 dimension of communication (p = 0.008). Subjects were divided into tertiles of cognitive decline from premorbid level. Scores in the dimension of stigma were worst in the second tertile of cognitive decline (p = 0.03). MCI was associated with worse social support scores in the second tertile of cognitive decline (p = 0.008). Conclusion: MCI and cognitive decline from premorbid baseline are associated with reduced HR-QOL in communication, stigma, and social support domains. The cognitive decline from premorbid baseline modifies the association between MCI and HR-QOL in PD and knowing both will allow a better appreciation of difficulties patients face in daily life.

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Section: Discussioncontrasting

confidence: 35%

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Reginold

Duff‐Canning

Meaney

et al. 2013

Dement Geriatr Cogn Disord

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“…Two previous studies found no differences in QoL between MCI patients and healthy controls, using different instruments to evaluate QoL (Missotten et al, 2008;Ready et al, 2004). The first study used the Dementia QoL Scale (Brod, Stewart, Sands, & Walton, 1999), an instrument Notes: Scores are mean (SD).…”

Section: Discussionmentioning

confidence: 99%

“…It is controversial whether QoL is already disturbed in more initial phases of cognitive decline, like Mild Cognitive Impairment (MCI), a clinical entity now accepted in both clinical practice and research that entails a high risk of progression to dementia. Some researchers found that QoL is not affected in MCI patients (Missotten et al, 2008;Ready et al, 2004) while other detected that some aspects of QoL are altered (Muangpaisan, Assantachai, Intalapaporn, & Pisansalakij, 2008).…”

Section: Introductionmentioning

confidence: 99%

Quality of life in patients with mild cognitive impairment

Bárrios

Narciso

Guerreiro

et al. 2013

Aging & Mental Health

143

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Background: Quality of life (QoL) is affected in patients with dementia, but it is not clear whether it is already disturbed in more initial phases of cognitive decline, like Mild Cognitive Impairment (MCI). Aim: Compare the QoL in MCI patients with controls without cognitive impairment, and ascertain whether there are differences in the reports of QoL made by the subjects and by their informants. Methods: Two hundred participants were enrolled, divided into MCI patients (n ¼ 50), MCI informants (n ¼ 50), recruited from a memory clinic and a dementia outpatient clinic, and controls (n ¼ 50) and controls informants (n ¼ 50), recruited in a family practice clinic. QoL was assessed with the QoL in Alzheimer disease (QOL-AD) scale. Results: The total scores of the QOL-AD questionnaire were 32.1 � 6.9 for MCI patients self-report, 27.2 � 6.7 for MCI patients in the opinion of their informants, 35.3 � 4.9 for controls self-report and 35.6 � 4.9 for controls in the opinion of their informants. MCI patients had lower QOL-AD scores than controls. The QoL reported by patients with MCI was more favorable than the opinion of their informants. Conclusion: The QoL is affected at early stages of cognitive decline. The QoL reported by patients with MCI is better than the opinion of their informants, similarly to what is known in Alzheimer's disease patients. QoL appears to be an important domain to be evaluated in aging studies.

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“…[1][2][3] Although MCI criteria continue to be refined, 4,5 the diagnostic tenet that MCI patients evidence largely intact functional abilities continues to be central. This reflects the clinical view that frank restriction in functional activities is a hallmark of AD and other dementias.…”

mentioning

confidence: 99%

“…6,7 However, an increasing number of cross-sectional studies have shown that persons with MCI experience limitations in functional abilities relative to cognitively healthy older adults. [1][2][3]8 The longitudinal course of such functional restrictions has received less attention. [9][10][11][12] Medical decision-making capacity (MDC) (also referred to as treatment consent capacity or consent capacity) is a higher-order functional capacity.…”

mentioning

confidence: 99%

Medical decision-making capacity in mild cognitive impairment

et al. 2008

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Objective: To investigate longitudinal change in the medical decision-making capacity (MDC) of patients with amnestic mild cognitive impairment (MCI) under different consent standards.Methods: Eighty-eight healthy older controls and 116 patients with MCI were administered the Capacity to Consent to Treatment Instrument at baseline and at 1 to 3 (mean ϭ 1.7) annual follow-up visits thereafter. Covariate-adjusted random coefficient regressions were used to examine differences in MDC trajectories across MCI and control participants, as well as to investigate the impact of conversion to Alzheimer disease on MCI patients' MDC trajectories.Results: At baseline, MCI patients performed significantly below controls only on the three clinically relevant standards of appreciation, reasoning, and understanding. Compared with controls, MCI patients experienced significant declines over time on understanding but not on any other consent standard. Conversion affected both the elevation (a decrease in performance) and slope (acceleration in subsequent rate of decline) of MCI patients' MDC trajectories on understanding. A trend emerged for conversion to be associated with a performance decrease on reasoning in the MCI group. Conclusions: Medical decision-making capacity (MDC) decline in mild cognitive impairment (MCI)is a relatively slow but detectable process. Over a 3-year period, patients with amnestic MCI show progressive decline in the ability to understand consent information. This decline accelerates after conversion to Alzheimer disease (AD), reflecting increasing vulnerability to decisional impairment. Clinicians and researchers working with MCI patients should give particular attention to the informed consent process when conversion to AD is suspected or confirmed. Neurology ® 2008;

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Quality of life in older Belgian people: comparison between people with dementia, mild cognitive impairment, and controls

Cited by 69 publications

References 47 publications

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Impact of Mild Cognitive Impairment on Health-Related Quality of Life in Parkinson's Disease

Quality of life in patients with mild cognitive impairment

Medical decision-making capacity in mild cognitive impairment

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