Quality of life in children with acute lymphoblastic leukaemia

Jankowska‐Polańska, Beata; Śliwiński, Maciej; Świątoniowska, Natalia; Butrym, Aleksandra; Mazur, Grzegorz

doi:10.1111/scs.12739

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…Zheng et al 16 conducted the largest study to date on HRQoL in children with ALL and found significant proportions of children with ALL experience impaired physical and emotional functioning beginning early in treatment and persisting. Other studies have found generally decreased HRQoL on therapy but improvement in scores as therapy progresses 26,28 . Our study supports and adds to the literature.…”

Section: Discussionsupporting

confidence: 86%

Hopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma

Parker

Durben²,

Oleson³

et al. 2023

Journal of Pediatric Hematology/Oncology

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Background: Survivors of acute lymphoblastic leukemia (ALL) can experience chemotherapy-related changes in neuromuscular function, which can persist and impact the quality of life. Clinically, neuromuscular changes are assessed by observing gait. The primary aims of this study were to compare observational gait/functional movement analysis to matched electronic gait analysis in children with ALL and lymphoblastic lymphoma at specific time points during and after treatment. Patients and Methods: Participants 2 to 27 years old diagnosed with ALL/lymphoblastic lymphoma who were on or off therapy within 10 years were eligible. Participants underwent electronic gait assessment using GAITRite, observational gait, and functional movement analysis and completed quality of life questionnaires. Parents also completed quality-of-life assessments. Results: Electronic gait parameters were not different in this cohort compared with controls. Mean overall scores on observational gait and functional movement analysis improved over time. Hopping was the most frequent and walking was the least frequent noted deficit. Participants had a lower patient and parent-reported QoL scores compared with the general population Conclusion: Observational gait and functional movement analysis identified more deficits than the electronic gait assessment. Future studies are warranted to determine whether hopping deficits are an early clinical indicator of toxicity and signal for intervention.

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Section: Discussionsupporting

confidence: 86%

Hopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma

Parker

Durben²,

Oleson³

et al. 2023

Journal of Pediatric Hematology/Oncology

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“…Given that the 5-year survival rate of ALL reaches up to 90%, the number of survivors has exponentially expanded throughout recent decades. The quality of life (QoL) of these long-term survivors can be compromised by sequelae [ 1 , 2 ], unpredictable health situations [ 3 ], depressive mood, fatigue, or weakness secondary to the ALL and its treatments [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…A significant proportion of patients experience these problems shortly after treatment (i.e., <1 year post-treatment) [ 4 ]. Although QoL is often observed to recover or improve throughout their development, some patients might continue to experience mental or physical difficulties into adulthood [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Sleurs

Musoro

Rowsell

et al. 2021

Cancers

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Background: due to increasing survival rates in childhood acute lymphoblastic leukemia (ALL), the number of survivors has been expanding. A significant proportion of these survivors can experience long-term emotional and psychosocial problems. However, the exact risk factors remain inconclusive. We investigated potential risk factors for decreased daily life quality and life challenges in long-term childhood ALL survivors enrolled between 1971 and 1998 in EORTC studies. Methods: self-report questionnaires were collected from 186 survivors (109 females; mean age at diagnosis 5.62 years, range 0.2–14.7; median time since diagnosis of 20.5 years (12.9–41.6)), including the Short-Form Health Survey (SF-12) and Impact of Cancer-Childhood Survivors (IOC-CS). Multivariable linear regression models were used to assess the impact of gender, age at diagnosis, relapse/second neoplasm, National Cancer Institute (NCI) risk group and cranial radiotherapy on 2 subscales of the SF-12 (physical and mental health) and five subscales of the IOC-CS (life challenges, body and health, personal growth, thinking and memory problems and socializing). Results: mental component scores of SF-12 were not significantly associated with any risk factor. Physical component scores were lower in relapsed, irradiated and NCI high-risk patients. Regarding IOC-CS negative impact subscales, life challenges was more negatively impacted by cancer in female, younger (i.e., <6 years) and relapsed patients. Regarding the positive impact scales, personal growth was more positively impacted in relapsed patients, whereas body and health, and socializing, were less positively impacted in these patients, compared to non-relapsed patients. Socializing was more positively impacted in older patients (>6 years). Conclusions: this study demonstrates that long-term outcomes can be both adverse and positive, depending on the patient’s demographic and clinical characteristics. Younger, female, and relapsed patients might encounter more life challenges years after their disease, while physical challenges could occur more often in relapsed and high-risk patients. Finally, the positive effect on socializing in the older patients sheds new light on the importance of peer interactions for this subgroup. Specific individual challenges thus need specialized support for specific subgroups.

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“…In the cross-sectional studies, two were related to the diagnostic phase (Magni et al, 1986; Ruccione et al, 1991), six were related to the initial/intermediate phases of treatment (i.e., the first year of treatment) (Iqbal & Siddiqui, 2002; Khazaeli et al, 2021; Sharan et al, 1995, 1999; Sint Nicolaas et al, 2016; Wang et al, 2017), and four were related to a later phase-maintenance (Daniel et al, 2018; Matthews et al, 2014; Rensen et al, 2020; Sherief et al, 2015). Two studies were related to any stage of active treatment (Irwanto et al, 2020; Jankowska-Polańska et al, 2020), and one was conducted from the initial treatment phases until maintenance (Steur et al, 2020). In addition, two studies were conducted from 6 months postdiagnosis to more than 12 months postdiagnosis (Bhattacharya et al, 2016) and 18 months postdiagnosis (Rao et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

Parental distress in childhood acute lymphoblastic leukemia: A systematic review of the literature.

Ferraz¹,

Santos²,

Pereira³

2024

Journal of Family Psychology

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The present study is a systematic review of factors and consequences of parental distress following their children's acute lymphoblastic leukemia (ALL) diagnosis. PubMed, Web of Science, and APA PsycInfo databases were searched. Twenty-eight papers were included, with only three longitudinal studies. Fifteen studies explored factors of parental distress, including sociodemographic, psychosocial, psychological, family, health, and ALL-specific variables. Correlations were found between social support, illness cognitions, coping strategies, and parental distress, as well as contradictory results regarding sociodemographic variables. Family cohesion and the overall impact of illness were associated with parental distress. Resilience factors contributed negatively to parental distress symptoms, and perceived caregiver strain and negative child's emotional functioning contributed positively. Thirteen papers explored the consequences of parental distress, including psychological, family, health, and social/education factors. Distress was correlated with care burden and contributed to family strain, child's symptom burden, and parental protective behavior. Significant correlations were found between parental distress, at diagnosis, and further adjustment of parents and children. Most papers reported correlations between parental distress and psychological condition and quality of life; few studies reported no association. Correlations between maternal depression and child's participation in education and social life were found. Differences on distress were found regarding parents' gender, age, children's group risk, and treatment phases. Longitudinal studies are needed to better understand the phenomenon and its consequences. Future interventions should address parents' mental health needs in an early and ongoing assessment in order to promote healthier outcomes.

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Quality of life in children with acute lymphoblastic leukaemia

Abstract: All co-authors have agreed to the submission and publication of this manuscript.QoL in children with ALL

Cited by 13 publications

References 33 publications

Hopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma

Hopping as an Indicator of Chemotoxicity: Gait Analysis in Patients With Leukemia and Lymphoma

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Parental distress in childhood acute lymphoblastic leukemia: A systematic review of the literature.

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