Quality of life and subjective sleep-related measures in bipolar disorder and major depressive disorder

Abstract

Purpose Diminished quality of life (QoL) has been reported in patients with mood disorders. QoL has also been shown to be decreased by sleep disturbances. Since sleep disorders are common in mood disorders, the aim of this study was to determine whether sleep characteristics are associated to QoL among patients with Bipolar Disorder (BD) and unipolar Major Depressive Disorders (MDD). Methods QoL was assessed in 170 patients with mood disorders (61 BD and 109 MDD), who also completed questionnaires measuring the severity of insomnia, sleepiness, chronotype preference and obstructive sleep apnea (OSA) probability index. Results Analyses showed that BD and MDD groups had similar QoL and sleep measures but the MDD group had higher OSA scores. In BD, correlations indicated a relationship between QoL and insomnia complaints and sleepiness, whereas in MDD, correlations indicated an association between QoL and insomnia complaints and OSA score. In both groups, QoL was related to depressive symptomatology. Linear regressions showed that, in BD, QoL was related to insomnia complaints and sleepiness even in the euthymic state, whereas in MDD, QoL was related to insomnia complaints but not in euthymic patients. Conclusion QoL is related to sleep differently in BD and MDD. The results suggest that insomnia and sleepiness are particularly high in BD even when patients are euthymic. These findings suggest that focusing on insomnia and sleepiness during different mood states of BD could increase QoL.

Assessment of the spectrum of depression and bipolarity in patients with type 1 diabetes

“…For others it may be more associated with their mental health condition (for instance the indicated affective disorders and their correlation with sleep quality) 38 . Studies show association between quality of life and subjective sleep‐related measures in BD and major depressive disorder, however, when we add factors connected with T1DM control, this makes sleep disturbances even more prominent 39 …”

“…38 Studies show association between quality of life and subjective sleep-related measures in BD and major depressive disorder, however, when we add factors connected with T1DM control, this makes sleep disturbances even more prominent. 39 Finally, we have examined the temperament traits distribution and severity in the examined population. We were searching for connections between trait severity, affective symptoms and metabolic control.…”

Determinants of quality of life among people with HIV and tuberculosis in an underserved area in Indonesia: a cross-sectional study

“…Although the complex or residual disease may also appear to develop HIV, people living with TB have never expected to experience severe TB symptoms similar to those with HIV. Community communication and awareness of TB may be lower than HIV [ 26 ]. Being non-Papuan with TB will be more resilient to cope with disability compared to Papuans.…”

The clinical, economic, and patient‐centric burden of insomnia symptom severity in adults with major depressive disorder in the United States

“…These few studies have mostly focused on the presence or absence of insomnia as a symptom and did not evaluate the association of insomnia symptom severity with health‐related outcomes among adults with MDD (Asche et al., 2010 ; Bolge et al., 2010 ). We identified one study that examined the relation between insomnia severity and health‐related quality of life (HRQoL) among an MDD population in Switzerland and found that higher insomnia symptom severity was associated with worse HRQoL (Jermann et al., 2021 ). However, that study examined only one aspect of burden, did not control for confounding variables, and was conducted with a clinical population (i.e., those currently seeking care for MDD) in a limited geographical area; the present study attempts to address these gaps.…”