Quality of Life After Iodine 125 Brachytherapy vs Enucleation for Choroidal Melanoma

Abstract

Objective: To describe health-and vision-targeted quality of life following treatment with iodine 125 brachytherapy vs enucleation for choroidal melanoma in a subgroup of patients who were treated and observed prospectively as part of a large randomized clinical trial. Main Outcome Measures: Difficulty with driving, near vision activities, and activities using stereopsis or binocularity; anxiety; and depression. Participants: Two hundred nine patients who enrolled in the Collaborative Ocular Melanoma Study trial for medium-sized tumors between March 1995 and July 1998 and gave informed consent prior to randomization to participation in an ancillary study of quality of life. Methods: Patients were interviewed by telephone by a trained interviewer from the Collaborative Ocular Melanoma Study Coordinating Center at baseline (prior to randomization), at 6 months, and on annual anniversaries of enrollment. The questionnaire battery included the Medical Outcomes Study Short Form 36, the Activities of Daily Vision Scale, the National Eye Institute Visual Function Questionnaire, and the Hospital Anxiety and Depression Scale. Additional questions concerning satisfaction with posttreatment appearance and concerns about cancer recurrence also were included in posttreatment interviews. Results: There was a significant increase in both treatment groups in levels of reported difficulty for most visionoriented activities, and in bodily and ocular pain, 6 months following treatment. Differences in visual function between treatment groups reported during follow-up were *Authors: Members of the writing team who signed authorship responsibility, financial disclosure, and copyright transfer statements for the group are listed at the end of this article.

Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

“…Moreover, worse "emotional functioning" corresponded to an elevated pre-treatment "worry about recurrence", as previously described by Barker et al [9]. In our study, "emotional functioning" subsequently improved after treatment, which was consistent with findings in previous studies [7,10,27,32]. Finally, we found that 3 months after treatment, "emotional functioning" returned to standard values for the German population [29].…”

Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

“…Moreover, worse "emotional functioning" corresponded to an elevated pre-treatment "worry about recurrence", as previously described by Barker et al [9]. In our study, "emotional functioning" subsequently improved after treatment, which was consistent with findings in previous studies [7,10,27,32]. Finally, we found that 3 months after treatment, "emotional functioning" returned to standard values for the German population [29].…”

Quality of Life, Depression, and Anxiety in Patients with Uveal Melanoma: A Review

“…Several reports were published [3, 16, 17]. The 2006 report focused on the comparison between the group randomized to enucleation ( n = 106) and the group randomized to brachytherapy ( n = 103) [17]. The HADS anxiety scores were analyzed over time by diagnostic category (“no anxiety” versus “possible or definite anxiety”).…”

Uveal melanoma: epidemiology, etiology, and treatment of primary disease

“……”

Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

“…Moreover, worse "emotional functioning" corresponded to an elevated pre-treatment "worry about recurrence", as previously described by Barker et al [9]. In our study, "emotional functioning" subsequently improved after treatment, which was consistent with findings in previous studies [7,10,27,32]. Finally, we found that 3 months after treatment, "emotional functioning" returned to standard values for the German population [29].…”

Quality of Life, Depression, and Anxiety in Patients with Uveal Melanoma: A Review

“…Several reports were published [3, 16, 17]. The 2006 report focused on the comparison between the group randomized to enucleation ( n = 106) and the group randomized to brachytherapy ( n = 103) [17]. The HADS anxiety scores were analyzed over time by diagnostic category (“no anxiety” versus “possible or definite anxiety”).…”

Uveal melanoma: epidemiology, etiology, and treatment of primary disease

“……”

Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

“…Moreover, worse "emotional functioning" corresponded to an elevated pre-treatment "worry about recurrence", as previously described by Barker et al [9]. In our study, "emotional functioning" subsequently improved after treatment, which was consistent with findings in previous studies [7,10,27,32]. Finally, we found that 3 months after treatment, "emotional functioning" returned to standard values for the German population [29].…”

Quality of Life, Depression, and Anxiety in Patients with Uveal Melanoma: A Review

“…Several reports were published [3, 16, 17]. The 2006 report focused on the comparison between the group randomized to enucleation ( n = 106) and the group randomized to brachytherapy ( n = 103) [17]. The HADS anxiety scores were analyzed over time by diagnostic category (“no anxiety” versus “possible or definite anxiety”).…”

Uveal melanoma: epidemiology, etiology, and treatment of primary disease

“……”