Qualitative Analysis of Remineralization Capabilities of Bioactive Glass (NovaMin) and Fluoride on Hydroxyapatite (HA) Discs: An In Vitro Study

Hsu, Shu‐Min; Alsafadi, Muhammad Yasser; Vasconez, Christina; Fares, Chaker; Crăciun, V.; O’Neill, Edgar; Ren, F.; Clark, A. E.; Esquivel‐Upshaw, Josephine F.

doi:10.3390/ma14143813

Cited by 12 publications

(18 citation statements)

References 28 publications

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“…This could be due to theadequate availability of calcium and phosphate from bioglass. Also, bioglass in thisvarnish leads to its sustained release of calcium and phosphate leading to theformation of fluorapatite crystals.Increased microhardness was seen in group 2 (sodium fluoride fortified with bioglass) when compared to group1 (sodium fluoride varnish) is suggestive of betterremineralization potential in group 2, this is in accordance with studies conducted by Al-Hussain et al, Srivastava et al and Mohapatra et al, using toothpaste, whichcompared fluoride toothpaste and fluoride bioglass toothpaste and showed betterremineralization with fluoride bioglass tooth paste 13 .Further studies are warranted to assess the effect of long-term use of remineralizingagents on the prevention and regression of WSLs in children. The use ofsupplementary instruments to measure the degree of improvement of incipient carieslesions is also helpful.…”

Section: Discussion:-supporting

confidence: 89%

Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

M.S¹,

Barkathunnisa²,

Anusha³

et al. 2022

IJAR

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Aim:- The present study is aimed to compare and evaluate the remineralization potential of Sodium fluoride varnish alone and sodium fluoride varnish fortified with bioglass Material And Method:- caries like lesions were produced and surface microhardness was evaluated. The specimens were then divided into 2 groups with 36 teeth in each group, accordingly remineralization treatment was employed. 36 teeth were treated with sodium fluoride varnish (duraphat) (group 1) and 36 teeth with treated with sodium fluoride fortified with bioglass (Fluro dip bioactive) (group 2). During the next 10 days, the samples were subjected to a pH-cycling system, which simulated the intraoral conditions, surface microhardnesstesting was performed on the 11th day to evaluate remineralization. The values obtained were tabulated and statistically analyzed using one-way ANOVA. Result:- Significant remineralization was seen with sodium fluoride fortified with bioglass followed by sodium fluoride varnish. Conclusion:- The results of the study concluded that sodium fluoride varnish fortified with bioglass has better remineralizing potential than Sodium fluoride varnish alone and can be used to reduce caries advancements at the stage of early carious lesions.

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Section: Discussion:-supporting

confidence: 89%

Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

M.S¹,

Barkathunnisa²,

Anusha³

et al. 2022

IJAR

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“…Furthermore, it was shown by other authors that the application of synthetic hydroxyapatite crystals results in the formation of newly mineralized surface layers [ 15 , 31 , 38 , 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Remineralization of Artificially Demineralized Human Enamel and Dentin Samples by Zinc-Carbonate Hydroxyapatite Nanocrystals

et al. 2022

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(1) Background: Decalcified enamel and dentin surfaces can be regenerated with non-fluoride-containing biomimetic systems. This study aimed to investigate the effect of a zinc carbonate-hydroxyapatite-containing dentifrice on artificially demineralized enamel and dentin surfaces. (2) Methods: Human enamel and dentin discs were prepared and subjected to surface demineralization with 30% orthophosphoric acid for 60 s. Subsequently, in the test group (n = 20), the discs were treated three times a day for 3 min with a zinc carbonate-hydroxyapatite-containing toothpaste (biorepair®). Afterwards, all samples were gently rinsed with PBS (5 s) and stored in artificial saliva until next use. Samples from the control group (n = 20) received no dentifrice-treatment and were stored in artificial saliva, exclusively. After 15 days of daily treatment, specimens were subjected to Raman spectroscopy, energy-dispersive X-ray micro-analysis (EDX), white-light interferometry, and profilometry. (3) Results: Raman spectroscopy and white-light interferometry revealed no significant differences compared to the untreated controls. EDX analysis showed calcium phosphate and silicon dioxide precipitations on treated dentin samples. In addition, treated dentin surfaces showed significant reduced roughness values. (4) Conclusions: Treatment with biorepair® did not affect enamel surfaces as proposed. Minor mineral precipitation and a reduction in surface roughness were detected among dentin surfaces only.

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“…The purpose of the study by Hsu et al (2021) [16] was to examine the effects of adding fluoride and/or bioactive glass (NovaMin) on the remineralization of hydroxyapatite (HA) discs, which are intended to mimic the enamel surface of real teeth. Surface morphologies were analyzed using scanning electron microscopy (SEM), and surface compositions were analyzed with X-ray photoelectron spectroscopy (XPS).…”

Section: Table 3 Summary Of Findings Of Selected Studiesmentioning

confidence: 99%

Effect of Bioactive Glass on the Remineralization of Caries Lesion: A Systematic Review

Hamazani¹,

Alwoseamer²,

AlWasem³

et al. 2022

Int J Pharm Res Allied Sci

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Bioactive glass's most well-known capacity is its bonding ability to bone and promoting bone development. The bioactive glass may mineralize dentine tubules for sensitive teeth to provide relief and prevent caries. Bioactive glass is an emerging therapy for regenerating damaged bone tissue after injury or illness. Its usefulness in the medical profession has led to its implementation in several areas. In 1969, a silicate glass made of sodium, calcium, and phosphorus was the first bioactive glass on the marketUsing the databases PubMed, Medline, and ScienceDirect, a comprehensive review of the literature spanning 2011 to 2022 was conducted. The keywords used were "bioactive glass" and "caries remineralization" .8 studies were included in this systematic review. However, most of them revealed that bioactive glass could not provide enough remineralization, especially when compared to fluoride. Although bioactive glass has shown encouraging signs of remineralization, its effectiveness is not to the standard produced by fluorides. Hence, there is a need to conduct further studies to reassure the importance of bioactive glass as a good replacement for fluoride.

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Qualitative Analysis of Remineralization Capabilities of Bioactive Glass (NovaMin) and Fluoride on Hydroxyapatite (HA) Discs: An In Vitro Study

Cited by 12 publications

References 28 publications

Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

Comparative Evaluation of Remineralization Potential of Sodium Fluoride Varnish and Sodium Fluoride Varnish Fortified With Bioglass -an in Vitro Study

Remineralization of Artificially Demineralized Human Enamel and Dentin Samples by Zinc-Carbonate Hydroxyapatite Nanocrystals

Effect of Bioactive Glass on the Remineralization of Caries Lesion: A Systematic Review

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