Quadruple malignancy in a single patient: A case report and comprehensive review of literature

Angurana, Shabab; Kapoor, Ravi; Kumar, Pankaj; Khosla, Divya; Kumar, Narendra; Sharma, Sushmita; Patel, FD

doi:10.4103/0973-1482.65237

Cited by 13 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…In Indian literature, scant data is available regarding multiple primaries, most of them being case reports, including two from our institute. [ 6 7 8 9 10 11 12 13 ] In this retrospective study, we have analyzed the multiple cancers encountered in the department of surgical oncology of a single institute over a 5 year study period.…”

Section: Introductionmentioning

confidence: 99%

Multiple primary cancers: An enigma

Jena

Patnayak

Lakshmi

et al. 2016

South Asian J Cancer

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Background:Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients.Materials and Methods:This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months.Results:A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma.Conclusion:Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

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Section: Introductionmentioning

confidence: 99%

Multiple primary cancers: An enigma

Jena

Patnayak

Lakshmi

et al. 2016

South Asian J Cancer

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“…Multiple primary malignancies (MPMs) were initially described by Billroth [ 1 ] in 1889 and later defined by Warren and Gates [ 2 ] as the presence of at least 2 unrelated primary malignancies in a single patient. Occurrences of MPMs are rare and are described mostly as case reports [ 3 , 4 ], although there are reports from single institutions and from the registries of certain countries [ 5 , 6 ]. The mechanism of development of MPMs is unclear and likely multifactorial; identified risk factors include previous cancer treatment, smoking, diet, and genetic mutations [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature

Williamson

Paravati

Ghassemi³

et al. 2015

Case Rep Oncol

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Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with 5 distinct tumors within 4 months: malignant melanoma of the right popliteal fossa, invasive lobular breast carcinoma, diffuse large B cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and a giant cell tumor of tendon sheath/pigmented villonodular synovitis. We discuss her treatment and also present a brief review of the literature. The incidence of MPMs appears to be on the rise, which demands an interdisciplinary, multimodal, and personalized approach to care.

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“…Carcinogenic insults, such as tobacco and alcohol, may increase the likelihood of multiple independent malignant foci developing in the mucosa epithelium. In addition, smoking and family history may be the key risk factors of multiple primary malignant neoplasms [ 14 , 15 ]. Some common points can be described in reviews of the literature about multiple primary malignancies.…”

Section: Discussionmentioning

confidence: 99%

Stomach Carcinoma Presenting with a Synchronous Liver Cancer: A Case Report and Literature Review

Wang

2014

Case Reports in Gastrointestinal Medicine

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Multiple primary malignant neoplasms are two or more malignancies in an individual without any relationship between the tumors. Multiple primary malignancies are relatively rare but have increased in recent decades. Two cancers are commonly observed among those with multiple primary malignancies, but two malignancies of stomach and liver are relatively rare to be reported. Mechanisms of the tumors were unclear; we described a patient who had stomach carcinoma presenting with a synchronous liver cancer and investigated his family history; we suggest that family history may be a key risk factor and early detection for additional primary malignancies should be needed for patients who had specific cancer history in their pedigree. Early diagnosis may be the key risk factor affecting prognosis.

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Quadruple malignancy in a single patient: A case report and comprehensive review of literature

Cited by 13 publications

References 4 publications

Multiple primary cancers: An enigma

Multiple primary cancers: An enigma

Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature

Stomach Carcinoma Presenting with a Synchronous Liver Cancer: A Case Report and Literature Review

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