2010
DOI: 10.1002/clc.20768
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Abstract: Background: Coronary artery disease (CAD) is the predominant cause of sudden cardiac death in the general population, and sudden cardiac death is the leading cause of mortality in end-stage renal disease (ESRD). Hypothesis: QT-interval prolongation is an independent prognosticator in ESRD. Methods: We reviewed clinical, electrocardiographic, stress test, and coronary angiography data on ESRD patients evaluated for transplantation at our institution between 2000 and 2004 who underwent coronary angiography. The … Show more

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Cited by 56 publications
(56 citation statements)
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“…403 Abnor mal ECGs, including QTc prolongation, are common among patients on hemodialysis, 404 and QT prolonga tion has been identified as an independent predictor of mortality for patients on hemodialysis. 405 As described in a review of 5 studies, SCD has been noted in patients on hemodialysis, most commonly occurring during the 72hour time frame between dialysis treatments and within the first 12 hours after receiving a treatment. 406 The Kidney Disease Workgroup 401 provided guidelines for evaluation of heart disease on initiation of dialy sis, including baseline and annual ECGs; however, no specific recommendations were provided for continu ous electrocardiographic monitoring during inpatient hemodialysis.…”
Section: Hemodialysismentioning
confidence: 99%
“…403 Abnor mal ECGs, including QTc prolongation, are common among patients on hemodialysis, 404 and QT prolonga tion has been identified as an independent predictor of mortality for patients on hemodialysis. 405 As described in a review of 5 studies, SCD has been noted in patients on hemodialysis, most commonly occurring during the 72hour time frame between dialysis treatments and within the first 12 hours after receiving a treatment. 406 The Kidney Disease Workgroup 401 provided guidelines for evaluation of heart disease on initiation of dialy sis, including baseline and annual ECGs; however, no specific recommendations were provided for continu ous electrocardiographic monitoring during inpatient hemodialysis.…”
Section: Hemodialysismentioning
confidence: 99%
“…We suggest that this finding is clinically important since both the QTc interval duration and aortic calcification are predictors of CV events and mortality in different patient populations including patients with end-stage renal disease [5,8,27]. Further research is necessary to confirm our data, to elucidate the pathophysiology underlying the association between arterial calcification and long QT and to further clarify the clinical implication of long QT specifically in the setting of CKD.…”
Section: Discussionmentioning
confidence: 79%
“…In patients with CKD, results regarding outcome are conflicting [5,6]. The association between QT duration and CV disease has been stated to reflect a relationship between abnormal repolarization and sudden death.…”
Section: Introductionmentioning
confidence: 99%
“…It is known that in the general population and in different patient groups a prolonged QT interval (electrocardiographic measure of the duration of ventricular repolarization) may cause life-threatening arrhythmias and sudden death [16]. Prevalence of QT interval prolongation in ESRD patients is elevated [17,18]. The causes of this finding are uncertain; however, a correlation between QT interval duration and aortic calcifications has been demonstrated [19].…”
Section: Calcium Overload Hypercalcemia and Ventricular Arrhythmiasmentioning
confidence: 99%
“…The causes of this finding are uncertain; however, a correlation between QT interval duration and aortic calcifications has been demonstrated [19]. Moreover, an association between QT interval prolongation and mortality in ESRD patients has been reported [17,18]. Intradialytic QT interval modifications are a complex phenomenon, mainly dependent on the interactions of changing plasma calcium and potassium levels.…”
Section: Calcium Overload Hypercalcemia and Ventricular Arrhythmiasmentioning
confidence: 99%