QT instability, an indicator of augmented arrhythmogenesis, increases with the progression of myxomatous mitral valve disease in dogs

Brüler, Bruna Cristina; Jojima, Flavio Shigueru; Dittrich, Gustavo; Giannico, Amália Turner; Sousa, Marlos Gonçalves

doi:10.1016/j.jvc.2018.06.002

Cited by 10 publications

(14 citation statements)

References 33 publications

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“…Regarding the long QT interval in dogs, Ware et al [ 21 ] related prolongation of the QT interval and sudden death in dogs of the English Springer Spaniel breed, and Brüler et al [ 22 ] concluded that QT interval prolongation and instability were significantly related to mortality in dogs and may be useful predictors in the prognosis of patients with myxomatous valve disease. In our study, no sudden death occurred, but the maximum duration of the QT interval and the dispersion of the QT interval were significantly higher in the IHD group immediately after the first session compared to the clinical treatment group, and significant differences in QT dispersion were observed when compared to the control group at the end of the third treatment session.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis

Alfonso

Sueur

Geraldes

et al. 2020

Animals

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Intermittent haemodialysis (IHD) is used in dogs with chronic kidney disease (CKD) to reduce azotaemia. Monitoring the cardiovascular system plays an important role in this treatment to detect cardiovascular repercussions. Heart rate variability (HRV) and dispersions of the QT interval and P wave are important markers for mortality risk in humans. This study aimed to describe the time-domain and frequency-domain heart rate variability indexes, P and QT dispersions and electrocardiographic alterations observed in dogs with Stage IV CKD undergoing IHD. Thirty dogs of both sexes, of varying ages and breeds, and weighing between 15 and 30 kg were used. Animals were divided into three groups, control (10 healthy dogs), clinical treatment (10 dogs with CKD IV submitted to clinical treatment twice a week) and IHD (10 dogs with CKD IV submitted to clinical treatment and to dialysis treatment with intermittent haemodialysis twice a week). Clinical, laboratory, HRV indexes and electrocardiographic parameters, as well as QT and P-wave dispersions, were assessed in both CKD groups, prior to and after the end of each clinical treatment/IHD session during the first three sessions. Dogs with CKD IV undergoing IHD had clinically important electrolyte imbalances, primarily hypokalaemia, and pertinent electrocardiographic findings, such as the occurrence of supraventricular arrhythmias and increases in possible predictive parameters for arrhythmias. In spite of these observations, HRV indexes were better in animals undergoing haemodialysis and, in addition, IHD was more effective at reducing levels of creatinine, urea and phosphorus compared to intravenous fluid therapy treatment.

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Section: Discussionmentioning

confidence: 99%

Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis

Alfonso

Sueur

Geraldes

et al. 2020

Animals

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“…Several studies were made to compare different formules of QTc (Matsunaga et al, 1997;Chiang et al, 2006;Watanabe and Miyazaki, 2006;Agudelo et al, 2011;Patel et al, 2017). QT interval is shortened in cases of increased cardiac rhythm under physiological conditions (Chiang et al, 2006;Brüler et al, 2018). Although the heart rhythm can change at high rates due to sinus arrhythmia caused by SA node in dogs, QT interval does not change due to QT "memory" (Hamlin et al, 2004;Patel et al, 2017;Matsuba et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Accuracy of electrocardiogram (ECG) has a very important role in the assessment of the heart (Matsubara et al, 2018). The QT interval in the electrocardiogram (ECG) shows the duration of ventricular depolarization and repolarization (Brüler et al, 2018). The prolongation of the QT interval indicates that the duration of ventricular repolarization is prolonged electrocardiographically, which is a risk factor for the development of various severe and life-threatening ventricular arrhythmias, including torsades de pointes (Matsunaga et al, 1997;Ackerman, 1998;Raunig et al, 2001;Chiang et al, 2006;Schmitt et al, 2007;Agudelo et al, 2011;Patel et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The prolongation of the QT interval indicates that the duration of ventricular repolarization is prolonged electrocardiographically, which is a risk factor for the development of various severe and life-threatening ventricular arrhythmias, including torsades de pointes (Matsunaga et al, 1997;Ackerman, 1998;Raunig et al, 2001;Chiang et al, 2006;Schmitt et al, 2007;Agudelo et al, 2011;Patel et al, 2017). Short QT syndrome is a recently described disease characterized by shortening of the QT interval and it is associated with paroxysmal atrial or ventricular fibrillation, fainting seizures and can cause sudden death in healthy people (Kijtawornrat et al, 2010;Brüler et al, 2018). QT interval depends on the heart rate, many physiological, pathological factors and medications, so that making interpretation of the data is very difficult (Matsunaga et al, 1997;Spence et al, 1998;Raunig et al 2001;Batey and Doe, 2002;Chiang et al, 2006;Watanabe and Miyazaki 2006;Schmitt, 2007;Fossa, 2008;Agudelo et al, 2011;Patel et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Determination of Corrected QT Interval in Kangal Breed Dogs

Gönül¹,

Koenhemsi²,

Yıldız³

et al. 2019

PVJ

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QT interval is one of the important reasons of severe and life threatening ventricular arrhythmias in humans and animals. Many formulas have been developed for correcting the QT interval however the best formula did not define yet by the researchers. For this reason, forty-nine clinically healthy Kangal dogs without cardiac problems other than sinus arrhythmia were included to the study. In this study corrected QT interval was determined by Bazet (QTcB = QT/√RR), Fridericia (QTcF = QT/ 3 √RR), Famingham (QT+0.154(1-RR)), Van der Water (QTcVdW = QT-0.087((60/HR)-1)), Hodges (QT+0.00175(HR-60)), Matsunaga (QTcM = log600 QT/logRR) formulas. As a result, Bazett's formula showed the best consistency because the slope curve of the regression line was closest to zero (-0.00743) in our study.

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“…У дрібних порід із прогресуванням ЕМК (Kim et al, 2017;Car-valho et al, 2018) зростає ймовірність розвитку СВА, поліморфних шлуночкових аритмій, а у великих і середніх (Jung et al, 2016;Keene et al, 2019) -у 52 % випадків виникає ФП. Окрім того, у собак із прогресуванням ЕМК пролонгація коригованого інтервалу QT та його дисперсія є ранніми індикаторами розладів реполяризації в міокарді та факторами ризику розвитку злоякісних шлуночкових аритмій (Bruler et al, 2018).…”

Section: вступunclassified

Electrocardiographic evaluation of cardiac activity in dogs with CHF

Trofimiak

Slivinska

2020

SMLNUVMB

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An important pathogenetic link of the progression of chronic heart failure of various genesis is the development of arrhythmias. They significantly complicate the course of CHF, because they lead to decreased cardiac output and increased hypoxia. The aim of our study was to investigate and evaluate the electrical activity of the heart of dogs with CHF. The research was performed on the basis of the private veterinary center “Vetmed” (Lviv) in 2016–2017. The study included 36 dogs of different breeds, ages, sexes with symptoms of chronic heart failure. A standard six-lead electrocardiogram (ECG) was recorded in all dogs in the right lateral position using an electrocardiograph “Vet ECG Ve – 300” (speed 50mm/s, sensitivity of the device 1mV = 10 mm). The obtained data were compared with reference values, and also took into account the variation of individual indicators depending on body weight. According to the results of our study, it was found that the frequency of arrhythmias in dogs with CHF is 75.0 %, of which 8.3 % – life-threatening, 38.9 % of the examined animals needed treatment, and 27.8 % – annual ECG monitoring. The signs of remodeling processes are found in 63.9 % of sick dogs, signs of ischemia – in 25 % and only in 2.8 % of animals – ECG without changes. The structure of arrhythmia in dogs with CHF is dominated by sinus tachycardia (47.2 %), sinus bradycardia (8.3 %), ventricular arrhythmias (5.6 %), atrial fibrillation (5.6 %), ventricular tachycardia (2.8 %). Among conduction disorders, we register intraatrial blockade (13.9 %) and AV-blockade of the first degree (8.3 %). In 13.9 % of animals ECG signs of fibrosis, ischemia are combined with changes in the size of the heart chambers. The results of our study show that a significant number of dogs with CHF have arrhythmias and conduction disorders. In order to improve diagnosis and treatment, the prospect of further research is to establish an association between ECG and echocardiographic changes in dogs with CHF, which can be both a cause of CH and its consequence and a predictor of an unfavorable prognosis.

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QT instability, an indicator of augmented arrhythmogenesis, increases with the progression of myxomatous mitral valve disease in dogs

Cited by 10 publications

References 33 publications

Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis

Heart Rate Variability and Electrocardiographic Parameters Predictive of Arrhythmias in Dogs with Stage IV Chronic Kidney Disease Undergoing Intermittent Haemodialysis

Determination of Corrected QT Interval in Kangal Breed Dogs

Electrocardiographic evaluation of cardiac activity in dogs with CHF

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