Q-switched ruby laser treatment of congenital nevi

Goldberg, David J.

doi:10.1001/archderm.131.5.621

Cited by 15 publications

(12 citation statements)

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“…Previous studies 6,7 have obtained significant improvements in CMN, but to our knowledge complete, long-term, clinical resolution has never been achieved. Complete fading of the entire lesion, without recurrence at any previous site after 5 years, may be related to the early therapeutic intervention when the patient was still an infant.…”

Section: Discussionmentioning

confidence: 74%

“…Despite the controversy, the QSRL has been utilized for the treatment of small and medium congenital nevi with sometimes good results. [6][7] However, in these previous reports the CMN were either incompletely removed or recurred within 1 year of laser treatment. The present article describes the complete clinical removal of a biopsy-documented medium- sized compound CMN, using the QSRL with no recurrence after 5 years, which we believe is the first report of such a favorable clinical result.…”

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confidence: 93%

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Q-Switched Ruby Laser Treatment of a Congenital Melanocytic Nevus

Nelson

Kelly

1999

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 74%

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confidence: 93%

Q-Switched Ruby Laser Treatment of a Congenital Melanocytic Nevus

Nelson

Kelly

1999

Dermatologic Surgery

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“…The ruby laser's energy is well absorbed by melanin with minimal absorption by hemoglobin, and the QSRL was the initial laser system used to destroy pigment in the 1960s. Modern QS systems have proven effective at removing both epidermal and dermal pigmented lesions in a manner similar to the aforementioned lasers (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Because of its strong absorption by superficial melanin, however, postoperative hypopigmentation is more often seen with its use than with other pigment-specific lasers.…”

Section: The Qs Ruby Laser (694 Nm)mentioning

confidence: 99%

“…The vast majority of pigmented nevi, for which patients seek removal, are harmless and simply cosmetically unacceptable. The QSRL, QS alexandrite, QS Nd:YAG laser, and PLDL systems are all efficacious for removal or lightening of melanocytic nevi (18,21,28,29,31,32,37,45,46). (Fig.…”

Section: Melanocytic Nevimentioning

confidence: 99%

Laser therapy for cutaneous hyperpigmentation and pigmented lesions

Alster

Lupton

2001

Dermatol Ther

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Selective treatment of pigmented lesions can be accomplished as a result of the recent technologic advancements made in cutaneous laser surgery. Melanin‐specific, high‐energy, pulsed lasers are being used successfully to remove most benign epidermal and dermal pigmented lesions, including lentigines, café‐au‐lait macules, melanocytic and blue nevi, drug‐induced and infraorbital hyperpigmentation, Becker's nevus, and nevus spilus. These acquired and congenital cutaneous pigmented lesions can be lightened and even permanently eradicated after a series of outpatient laser treatments, with minimal risk of permanent sequelae, such as scarring, skin atrophy, or pigmentary irregularities. Because of the enhanced cosmetic effect of these lasers and their relative ease of use, they are becoming the mainstay of treatment for a variety of pigmented lesions and pigmentary disorders.

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“…Because treatment of benign pigmented lesions with Q-switched mode lasers has been shown to result in a low incidence of scarring, these lasers have been utilized to treat congenital melanocytic nevi. [2][3][4][5][6][7] Following Q-switched-mode laser treatment, however, congenital melanocytic nevi do not show complete histologic clearance, and many patients have partial repigmentation within several months after discontinuation of therapy. In addition, the number of recurrent pigmented macules has been found to increase in some patients.…”

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confidence: 99%

Recurrent Pigmented Macules after Q-Switched Alexandrite Laser Treatment of Congenital Melanocytic Nevus

Sohn¹,

Kim²,

Kang³

2004

Dermatol Surg

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Background. Q‐switch‐mode laser treatment of congenital nevi does not result in complete histological clearance, and many patients have partial repigmentation within several months. In addition, the number of recurrent pigmented macules (RPMs) may increase, a major drawback to good cosmetic results. While the mechanism of recurrence is not known. Objective. To help elucidate the mechanism of RPM development, we evaluated the expression of TNF‐alpha and E‐cadherin on RPM after treatment of congenital nevi with a Q‐switched alexandrite laser (QSAL). Methods. Thirteen Korean subjects with congenital nevi received QSAL treatment at intervals ranging from 2 to 6 months (mean, 4.5 treatments). Two‐millimeter punch biopsy specimens were obtained at their first visit and from RPMs 3–6 months after the last treatment. Expression of E‐cadherin and TNF‐alpha were determined histochemically in the original nevi and RPM. In addition, one RPM was examined by electron microscopy. Results. Reduced pigmentation in the treated areas was seen in all cases, but partial repigmentaion was seen as black spots within 6 months after the last QSAL treatment. Compared to the original nevi, the RPMs had increased numbers of melanocytes in the epidermis and reduced nevomelanocytic nests in the dermis. The expression of TNF‐alpha and E‐cadherin was downregulated in the RPMs compared to the original nevi. Electron microscopy confirmed the increase in melanocytes in the epidermis of RPMs. Conclusion. Our findings suggest that the down‐regulation of E‐cadherin and TNF‐alpha may induce the proliferation of melanocytes, resulting in the formation of RPMs.

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Q-switched ruby laser treatment of congenital nevi

Cited by 15 publications

References 0 publications

Q-Switched Ruby Laser Treatment of a Congenital Melanocytic Nevus

Q-Switched Ruby Laser Treatment of a Congenital Melanocytic Nevus

Laser therapy for cutaneous hyperpigmentation and pigmented lesions

Recurrent Pigmented Macules after Q-Switched Alexandrite Laser Treatment of Congenital Melanocytic Nevus

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